Biology of depression: From novel insights to therapeutic strategies. Vol. 1

‘This volume provides the most comprehensive presentation to date of the phenomenology, clinical aspects and cognitive therapy of persistent depression. The text is highly readable, replete with illustrative case material, and highlighted by concise summaries at the end of each chapter. The treatment approach, already validated in the famed Cambridge–Newcastle clinical trial, is an invaluable contribution.'Aaron T. Beck, M.D. Drawing on extensive clinical experience, Richard G. Moore and Anne Garland present a cognitive model of persistent depression that places particular importance on the role of thinking styles, underlying beliefs, subtle forms of avoidance and environmental factors. For the practitioner, this book offers guidance on how to address particular issues that commonly arise at each stage of therapy, such as: the patient is reluctant to engage in therapy the patient's negative thinking does not respond to standard therapeutic techniques the patient's negative beliefs have much basis in their experience the therapist becomes demoralised by the apparent lack of progress in therapy Through extensive clinical material, Cognitive Therapy for Chronic and Persistent Depression demonstrates how entrenched negative thinking patterns and ongoing avoidance can be addressed to achieve significant change in many people's lives. This book is essential reading for any therapist working with these hard to help patients, such as clinical psychologists, psychiatric nurses, psychiatrists, social workers and counsellors.

based On Decades Of Theory, Research, And Practice, This Seminal Book Presents A Detailed And Comprehensive Review, Evaluation, And Integration Of The Scientific And Empirical Research Relevant To Aaron T. Beck's Cognitive Theory And Therapy Of Depression. Since Its Emergence In The Early 1960s, Beck's Cognitive Perspective Has Become One Of The Most Influential And Well-researched Psychological Theories Of Depression. Over 900 Scientific And Scholarly References Are Contained In The Present Volume, Providing The Most Current And Exhaustive Evaluation Of The Scientific Status Of The Cognitive Theory Of Depression.

Though The Application Of Cognitive Therapy Has Been Well Documented In The Publication Of Treatment Manuals, The Cognitive Theory Of Depression Has Not Been Presented In A Unified Manner Until The Publication Of This Book. Coauthored By The Father Of Cognitive Therapy, Scientific Foundations Of Cognitive Theory And Therapy Of Depression Offers The Most Complete And Authoritative Account Of Beck's Theory Of Depression Since The Publication Of Depression: Causes And Treatment In 1967. Through Its Elaboration Of Recent Theoretical Developments In Cognitive Theory And Its Review Of Contemporary Cognitive-clinical Research, The Book Represents The Current State Of The Art In Cognitive Approaches To Depression. As A Result Of Its Critical Examination Of Cognitive-clinical Research And Experimental Information Processing, The Authors Offer Many Insights Into The Future Direction For Research On The Cognitive Basis Of Depression.

The First Half Of The Book Focuses On A Presentation Of The Clinical Phenomena Of Depression And The Current Version Of Cognitivetheory. After Outlining Important Questions That Have Been Raised With The Diagnosis Of Depression, The Book Then Traces The Historical Development Of Beck's Cognitive Theory And Therapy Through The 1960s And '70s. It Presents The Theoretical Assumptions Of The Model And Offers A Detailed Account Of The Most Current Version Of The Cognitive Formulation Of Depression.

The Second Half Of The Book Provides An In-depth Analysis Of The Empirical Status Of The Descriptive And Vulnerability Hypotheses Of The Cognitive Model. Drawing On Over Three Decades Of Research, The Book Delves Into The Scientific Basis Of Numerous Hypotheses Derived From Cognitive Theory, Including Negativity, Exclusivity, Content Specificity, Primacy, Universality, Severity/persistence, Selective Processing, Schema Activation, Primal Processing, Stability, Diathesis-stress, Symptom Specificity, And Differential Treatment Responsiveness.

In 1967 The First Detailed Description Of The Cognitive Theory Of Depression Was Published In Depression: Causes And Treatment By One Of Us, Aaron T. Beck. The Basic Concepts Of The Theory Laid Out In That Volume Still Provide The Foundation For The Cognitive Model 30 Years Later. As Well The First Systematic Investigations Of The Theory Described In The 1967 Volume Contributed To A Paradigmatic Shift In Theory, Research, And Treatment Of Depression That Resulted In A Very Vigorous And Widespread Research Initiative On The Cognitive Basis Of Depression. The Present Book Is Intended To Provide A Comprehensive And Critical Update Of The Developments In Cognitive Theory And Research On Depression That Have Occurred Since The Initial Publication In The 1960s.—david A. Clark, From The Preface.

john K. Larson

the Authors For This Ambitious Volume Provide An Exhaustive Review Of Over 900 Scholarly References And Offer A Unified Representation Of The Cognitive Theory Of Depression Heretofore Unavailable. The Purpose Is To Present Recent Theoretical Developments In Cognitive Theory And The Most Current Empirical Support For The Cognitive Therapy Of Depression. The Primary Audience Includes Psychotherapy Researchers And Advanced Practitioners Of Cognitive Therapy But Should Also Appeal To Psychotherapists At All Levels Of Experience Who Desire A Comprehensive Exploration Of The Topic. The Book Contains Eleven Chapters, An Unusually Complete Reference Section, An Author Index, And A Subject Index. The Authors Begin With A General Overview Of Depressive Symptoms With Diagnostic And Conceptual Considerations Followed By An Historical Overview And An Exploration Of The Philosophical Basis Of Cognitive Theory. The Remainder Of The Book Includes An In-depth Analysis Of The Empirical Status Of Numerous Hypotheses Of The Cognitive Model Including Negativity, Exclusivity, Content Specificity, Selective Processing, Schema Activation, Diathesis-stress, And Differential Treatment Response. There Are No Figures Or Tables. The Writing Is Uniformly Excellent. The Authors Intentionally Limit The Scope To Depression And Hint At Possible Future Volumes On Other Diagnoses. This Book Is An Extremely Successful Effort To Reflect The Development Of Cognitive Theory Over The Past Thirty Years. It Is Not Intended As A How To Guide And Its Scholarly Depth And Comprehensiveness May Put Off The Casual Reader. However, For The Most Complete And Thoughtful Analysis Of The Current State Of Cognitive Theory, Theserious Reader Need Look No Further.

Content: Preface.List of Contributors.Abbreviations.1 Classification of Depression: Research and Diagnostic Criteria: DSM-IV and ICD-10 (Alan M. Gruenberg, Reed D. Goldstein and Harold Alan Pincus).2 Psychosocial and Environmental Formulations of Depression (Gordon Parker and Kay Parker).3 The Economic Burden of Depression: Societal and Patient Perspectives (Paul E. Greenberg and Howard G. Birnbaum).4 The Depressive Spectrum: Reconceptualizing the Relationship between Dysthymic, Subthreshold and Major Depressions (Hagop S. Akiskal and Lewis L. Judd).5 The Monoamine Hypothesis of Depression (Leslie Iversen).6 Monoaminergic-based Pharmacotherapy for Depression (George I. Papakostas and Maurizio Fava).7 Psychobiology of Electroshock (Max Fink).8 Current Prognosis of Depression (H. Brent Solvason and Alan Schatzberg).9 Treatment of Depression in Medical Illness (Charles L. Raison, David C. Purselle, Lucile Capuron and Andrew H. Miller).10 Depression and Suicidality in Children and Adolescents (Cynthia R. Pfeffer).11 The Biology and Genetics of Suicidality (Gustavo Turecki and Aleksandra Lalovic).12 Geriatric Depression (Bindu Shanmugham and George Alexopoulos).13 Comorbidity of Depression and Substance Abuse (Edward V. Nunes and Wilfred N. Raby).14 Depression in the Context of Cancer (Elliot J. Coups, Jeremy Winell and Jimmie C. Holland).15 Treatment of Refractory Depression (Michael Gitlin).16 Clinical Pharmacology of New Classes of Antidepressant Drugs (Justine M. Kent).17 Neuroimaging and Neuropathological Studies of Mood Disorders (Wayne C. Drevets and Joseph L. Price).18 Dysregulation of Circadian Rhythms in Mood Disorders: Molecular Mechanisms (Blynn G. Bunney, Steven G. Potkin and William E. Bunney).19 Neuropeptidergic Dysfunction in Depression (Garth Bissette).20 Depression, Mania, and Thyroid Function: A Story of Intimate Relationships (Peter C. Whybrow and Michael Bauer).21 Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities (P. W. Gold).22 Neuroimmune Mediators: Are Cytokines Mediators of Depression? (Renaud de Beaurepaire, Artur H. Swiergiel and Adrian J. Dunn).23 Borna Disease Virus: Impact on Mood and Cognition (Liv Bode, Detlef E. Dietrich and Hanns Ludwig).24 Depression and Heart Disease (Robert M. Carney and Kenneth E. Freedland).25 Genetic Substrates Shared by Depression and Cardiovascular Disease (Brigitta Bondy).26 History and Epidemiology of Depression (Ma-Li Wong).27 Major Depression and Animals Models (Ma-Li Wong).28 Loss and Deprivation: From Animal Models to Clinical Presentation (Kristin M. Penza, Christine Heim and Charles B. Nemeroff).29 Neurogenomics of depression (Klaus Peter Lesch).30 Genetic Approaches to Depression: Linkage Studies (Francis M. Mondimore and James B. Potash).31 Genetic Approaches to Depression: Association Studies (Kopal Tandon and Katherine J. Aitchison).32 Molecular Effects of Antidepressant Treatments (Pierre Sokoloff).33 The Role of Transcription Factors in the Biology of Depression (Robert D. Beech and Ronald S. Duman).34 Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action (Ma-Li Wong).35 Pharmacogenetics of Antidepressant Drug Metabolism and Its Clinical Implications (Adrian Llerena).36 Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response (Kristopher J. L. Irizarry).37 Emerging Treatments for Depression: Beyond the Monoamine Hypothesis (Julio Licinio).38 Antidepressants and Suicide: Clinical Considerations (Julio Licinio).39 Depression in Developing Countries (Mauricio Silva de Lima and Bernardo Garcia de Oliveira Soares).40 Complementary and Alternative Medical Treatment for Depression (Peter B. Bongiorno).41 The Experience of Depression (Susan Blauner, Catherine Bond, Philip J. Burguieres, Ma-Li Wong, Julio Licinio, and Deborah L. Flores).Subject Index. Based on decades of theory, research, and practice, this seminalbook presents a detailed and comprehensive review, evaluation, andintegration of the scientific and empirical research relevant toAaron T. Beck's cognitive theory and therapy of depression. Sinceits emergence in the early 1960s, Beck's cognitive perspective hasbecome one of the most influential and well-researchedpsychological theories of depression. Over 900 scientific andscholarly references are contained in the present volume, providingthe most current and exhaustive evaluation of the scientific statusof the cognitive theory of depression. Though the application of cognitive therapy has been welldocumented in the publication of treatment manuals, the cognitivetheory of depression has not been presented in a unified manneruntil the publication of this book. Coauthored by the father ofcognitive therapy, Scientific Foundations of Cognitive Theory andTherapy of Depression offers the most complete and authoritativeaccount of Beck's theory of depression since the publication Causes and Treatment in 1967. Through its elaborationof recent theoretical developments in cognitive theory and itsreview of contemporary cognitive-clinical research, the bookrepresents the current state of the art in cognitive approaches todepression. As a result of its critical examination ofcognitive-clinical research and experimental informationprocessing, the authors offer many insights into the futuredirection for research on the cognitive basis of depression. The first half of the book focuses on a presentation of theclinical phenomena of depression and the current version ofcognitive theory. After outlining important questions that havebeen raised with the diagnosis of depression, the book then tracesthe historical development of Beck's cognitive theory and therapythrough the 1960s and '70s. It presents the theoretical assumptionsof the model and offers a detailed account of the most currentversion of the cognitive formulation of depression. The second half of the book provides an in-depth analysis of theempirical status of the descriptive and vulnerability hypotheses ofthe cognitive model. Drawing on over three decades of research, thebook delves into the scientific basis of numerous hypothesesderived from cognitive theory, including negativity, exclusivity,content specificity, primacy, universality, severity/persistence,selective processing, schema activation, primal processing,stability, diathesis-stress, symptom specificity, and differentialtreatment responsiveness. "In 1967 the first detailed description of the cognitive theory ofdepression was published in Causes and Treatment by oneof us, Aaron T. Beck. The basic concepts of the theory laid out inthat volume still provide the foundation for the cognitive model 30years later. As well the first systematic investigations of thetheory described in the 1967 volume contributed to a paradigmaticshift in theory, research, and treatment of depression thatresulted in a very vigorous and widespread research initiative onthe cognitive basis of depression. The present book is intended toprovide a comprehensive and critical update of the developments incognitive theory and research on depression that have occurredsince the initial publication in the 1960s."--David A. Clark, fromthe Preface. Address The Most Urgent Issues, Combining A Solid Basic Research Approach With Applied Individual And Stress Issues, Including Interventions. Throughout, The Focus Is On Our Latest Knowledge About Various Causes Of Stress And Its Neuro-cognitive And Biological Implications. Authors From Europe As Well As The Us Describe How Stress Affects The Brain Of Young People As Well As Adults. They Cover The Topic From All Perspectives, Showing How Stress Affects Life In General, From The Societal And Organizational Level To The Individual, Organ And Molecular Level. While The Book Clearly Points Out Stress As A Risk Factor To Health, It Also Offers A Number Of Evidence-based Methods To Cope With Stress And Even Ride The Positive Energy Of Stress - Both As An Individual, As Well As What Managers Can Do To Create A Healthy And Productive Workplace. Written In A Reader-friendly And Appealing Style, The Book Provides Real-life Examples From Various Laboratories, As Well As Such Events As T. Modern Fatigue : A Historical Perspective / Karin Johannisson -- Evolutionary Aspects Of Stress / Björn Folkow -- Stress : It Is All In The Brain / Hege Randi Eriksen And Holger Ursin -- Collective Traumatic Stress : Crisis And Catastrophes / Lars Weisœth -- Stress : Why Managers Should Care / Bengt B. Arnetz -- The Empowered Organization And Personnel Health / Töres Theorell -- Can Health Be Subject To Management Control? : Suggestions And Experiences / Ulf Johanson And Andreas Backlund -- The Neonatal And Pubertal Ontogeny Of The Stress Response : Implications For Adult Physiology And Behavior / Russell D. Romeo And Bruce S. Mcewen -- Neurobiological And Behavioral Consequences Of Exposure To Childhood Traumatic Stress / Martin H. Teicher ... [et Al.] -- The Brain In Stress : Influence Of Environment And Lifestyle On Stress-related Disorders / Rolf Ekman And Bengt B. Arnetz -- The Healthy Cortisol Response / Tommy Olsson And Robert Sapolsky -- Antistress, Well-being, Empathy And Social Support / Kerstin Uvnäs Moberg And Maria Petersson -- Stress, Sleep And Restitution / Torbjörn Åkerstedt -- Brain Mechanisms In Stress And Negative Affect / Mats Fredrikson And Tomas Furmark -- Is It Dangerous To Be Afraid? / Markus Heilig -- Fatigue And Recovery / Bengt B. Arnetz And Rolf Ekman -- The Role Of Stress In The Etiology Of Medically Unexplained Syndromes / James Rubin And Simon Wessely -- Oxidative Inflammatory Stress In Obesity And Diabetes / Paresh Dandona ... [et Al.] -- The Metabolic Syndrome / Christian Berne And Per Björntorp -- Chronic Pain : The Diathesis-stress Model / Yuan Bo Peng, Perry N. Fuchs, And Robert J. Gatchel -- Emotional Stress, Positive Emotions, And Psychophysiological Coherence / Rollin Mccraty And Dana Tomasino -- Stress Systems In Aging : Cognitions And Dementia / Nicole C. Schommer And Isabella Heuser -- Stress And Addiction / Bo Söderpalm And Anna Söderpalm. Edited By Bengt B. Arnetz And Rolf Ekman. Includes Bibliographical References And Index. Also Available In An Electronic Version. Mode Of Access: World Wide Web. Introduction To Pharmacogenomics: Promises, Opportunities, And Limitations -- Human Genome -- Turning Snps Into Useful Markers Of Drug Response -- Association Studies In Pharmacogenomics -- Genomics Applications That Facilitate The Understanding Of Drug Action And Toxicity -- Role Of Pharmacogenetics In Drug Discovery And Therapeutics -- Pharmacogenomics And Drug Design -- Pharmacogenomics Of Human P-glycoprotein -- Pharmacogenomics Of Drug Transporters -- Pharmacogenomics Of Asthma Treatment -- Endothelial Cells Are Targets For Hydroxy Urea: Relevance To The Current Therapeutic Strategy In Sickle Cell Disease -- Pharmacogenomics And Complex Cardiovascular Diseases -- Clinical Studies In Candidate Genes -- Pharmacogenomics Of Lipid-lowering Agents -- Pharmacogenomics Of Chemotherapeutic Agents In Cancer Treatment -- Pharmacogenomics Of The Blood-brain Barrier -- Pharmacogenomics And The Treatment Of Neurological Disease -- Pharmacogenomics Of Neurodegenerative Diseases: Examples And Perspectives -- Psychiatric Pharmacogenetics: Prediction Of Treatment Outcomes In Schizophrenia -- Pharmacogenomics Of Major Depression And Anitdepressant Treatment -- Pharmacogenomics Of Bipolar Disorder -- Pharmacogenomics Of Alcoholism -- Pharmacogenomics Of Tobacco Addiction -- Pharmacogenomics Of Opioid Systems -- Ethnicity And Pharmacogenomics -- Pharmacogenomics: Ensuring Equity Regarding Drugs Based On Genetic Difference -- Translation Of Vascular Proteomics Into Individualized Therapeutics -- Glossary Of Key Terms In Molecular Genetics Of Pharmacogenomics. Edited By Julio Licinio And Ma-li Wong. Includes Bibliographical References And Index. Also Available In An Electronic Version. Mode Of Access: World Wide Web. Ssris Have Been Used As An Effective Treatment For Depression For Many Years. Recently They Have Been Used More Widely In The Treatment Of Anxiety Disorders. This Title Outlines The Current State Of Thinking On The Origins Of Anxiety, Its Biological Basis, How It Relates To Depression And Various Anxiety Disorders As Well As The Biological And Clinical Effects Of Ssris On Such Conditions. Ssris In Depression And Anxiety, Second Edition, Will Provide A Timely Update On The Use Of Ssris As Their Application In This Area Becomes More Widespread. The Book Will Be Valuable Reading For Psychiatrists, Psychologists, Pharmacologists, Primary Care Physicians And All Health Care Professionals Who Manage Patients With These Common Disorders.--jacket. 1. Epidemiology Of Depression And Anxiety Disorders / A. Pelissolo And J.-p. Lepine -- 2. Biological Aspects Of Anxiety Disorders And Depression / J. A. Den Boer, B. R. Slaap And F. J. Bosker -- 3. Comorbidity Of Depression And Anxiety Disorders / Ronald C. Kessler -- 4. Utility Of Ssris In Anxious Depression / William Boyer And John P. Feighner -- 5. Ssris In Panic Disorder / James C. Ballenger -- 6. Social Anxiety Disorder Treatment Role Of Ssris / R. Bruce Lydiard -- 7. Ssris In Obsessive-compulsive Disorder / Stuart A. Montgomery -- 8. Serotonin And Serotonergic Drugs In Post-traumatic Stress Disorder / Jonathan R. T. Davidson And Kathryn M. Connor -- 9. Ssris In The Treatment Of Generalized Anxiety Disorder / David S. Baldwin. Edited By Stuart A. Montgomery And Johan A. Den Boer. Includes Bibliographical References And Index. Also Available In An Electronic Version. Mode Of Access: World Wide Web. This volume provides the most comprehensive presentation to date of the phenomenology, clinical aspects and cognitive therapy of persistent depression. The text is highly readable, replete with illustrative case material, and highlighted by concise summaries at the end of each chapter. The treatment approach, already validated in the famed CambridgeNewcastle clinical trial, is an invaluable contribution. Aaron T. Beck, M.D. Drawing on extensive clinical experience, Richard G. Moore and Anne Garland present a cognitive model of persistent depression that places particular importance on the role of thinking styles, underlying beliefs, subtle forms of avoidance and environmental factors. For the practitioner, this book offers guidance on how to address particular issues that commonly arise at each stage of therapy, such Through extensive clinical material, Cognitive Therapy for Chronic and Persistent Depression demonstrates how entrenched negative thinking patterns and ongoing avoidance can be addressed to achieve significant change in many peoples lives. This book is essential reading for any therapist working with these hard to help patients, such as clinical psychologists, psychiatric nurses, psychiatrists, social workers and counsellors. The first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches. In addition, the book covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.

for Fellow Practicing Therapists, Clinical Psychologist Moore (addenbrooke's Hospital, Cambridge, England) And Nurse Consultant Garland (nottingham Psychotherapy Unit) Describe Some Of The Ideas And Experiences That Have Been Successful In Developing And Applying Cognitive Therapy With Depressed Patients Over The Years, As Well As Some Interventions That Did Not Result In The Desired Or Anticipated Outcome. Biographies Are Provided For The Subjects Of Their Case Studies. Annotation ©2003 Book News, Inc., Portland, Or

This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research. In addition to renowned editors, the list of contributors is a "who-is-who" in the field. Broad coverage of all aspects of pharmacogenomics with a full presentation of applications to disease conditions is featured. Anyone involved in pharmaceutical research and drug development needs this book to keep up with this new and revolutionary approach A synthesis of decades of research and practice, this seminal book presents and critically evaluates the scientific and empirical status of co-author Aaron Beck's revised cognitive theory and therapy of depression. The authors explore the evolution of cognitive theory and therapy of depression, and discuss the future directions for the treatment of depression. This first book to address the most urgent issues combines a solid research approach with applied individual and stress issues. It focuses on our latest knowledge of various causes of stress and its neuro-cognitive and biological implications. World-renowned authors cover all perspectives: societal, individual, organ and molecular level. . Epidemiologic studies in psychiatry may provide fundamental information on the prevalence, distribution, comorbidity, risk factors and course of mental disorders, as well as data in quality of life, social cost and demand and use of health services associated with those disorders. "This book is essential reading for any therapist working with these hard to help patients, such as clinical psychologists, psychiatric nurses, psychiatrists, social workers and counsellors."--Jacket.