Biology and Therapy of Acute Leukemia : Proceedings of the Seventeenth Annual Detroit Cancer Symposium Detroit, Michigan — April 12–13, 1984

This year notes two major changes in the annual Detroit Cancer Symposium. The first is our intention of selecting top­ ics of broad interest to the cancer community and examining the subject from both a basic laboratory and clinical viewpoint. In this way, the importance of both elements of cancer research are noted and the interplay between them emphasized. Further, we believe that Symposia such as this act to stimulate the basic scientist and clinician to continue their studies with the know­ ledge of the impact that each has upon the other and the nec­ essary cooperation required to solve the cancer problem. The second change is the publication of this Symposium. The pre­ vious sixteen were not committed to manuscript form. Given the change in format and intent of the series, we believe that this and subsequent volumes will make important contributions to the cancer literature. The topic of "Biology and Therapy of Acute Leukemia" was chosen for the first Symposium because of its historical signif­ icance in cancer chemotherapy. The therapeutic rationale for human leukemia is the result of understanding the basic tumor biology largely derived from transplantable leukemias in exper­ imental animals. It is through these models, as discussed by Dr. Fred Valeriote, that we learned the cellular kinetics of leukemia, the antileukemic effects of new agents and the ef­ fect of growth perturbation by various chemotherapeutic agents and their combinations. Front Matter....Pages i-xii The Impact of Treatment on the Natural History of Acute Leukemia....Pages 1-7 Experimental Rationale for Therapy in the Treatment of Acute Leukemia....Pages 8-42 Clinical Laboratory Methods Used for the Classification of Acute Leukemia....Pages 43-52 HTLV-II and Human Leukemia....Pages 53-64 Oncogene Expression and Arrangement in Human Leukemia....Pages 65-76 Clonal Variation and Phenotypic Progression in Retrovirus Transformed Leukemia Cells....Pages 77-96 Chemotherapeutic Agents as Differentiation Inducers....Pages 97-105 Modes of Drug Resistance in Acute Leukemias....Pages 106-112 The Evolution of Therapy for Acute Lymphatic Leukemia in Children....Pages 113-141 Prognostic Factors in Childhood Acute Lymphoblastic Leukemia: Correlation with Treatment Response....Pages 142-157 Clinical Trials in Adult ANLL: An Overview....Pages 158-174 Allogeneic Marrow Transplantation for Acute Nonlymphoblastic Leukemia in Adults....Pages 175-187 Treatment Choices for Patients with Acute Nonlymphocytic Leukemia in Remission: Chemotherapy and Bone Marrow Transplantation....Pages 188-195 Autologous Bone Marrow Transplantation in Acute Leukemia....Pages 196-212 Treatment of Leukemia and Lymphoma with Biological Response Modifiers....Pages 213-229 Transfusion Therapy for the Support of Leukemia Patients....Pages 230-244 Leukemia: Hemorrhagic and Thrombotic Complications....Pages 245-259 Proceedings of the Seventeenth Annual Detroit Cancer Symposium, held in Detroit, Michigan, April 12-13, 1984