Biology and Management of Multiple Myeloma (Current Clinical Oncology)

Expert physicians and clinical researchers summarize and explain all the recent advances in the biology and treatment of bone marrow-based malignancy. On the biological side, the authors show the characteristics of the malignant cell and describe the significant roles played by oncogenic changes, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic factors are also analyzed. On the clinical side, the authors provide a comprehensive review of conventional treatment regimens, as well as a discussion of newer experimental approaches involving immunologic targeting, inhibitors of drug resistance, and antitumor agents.

Berenson (Institute for Myeloma and Bone Cancer Research) collects work by physicians and clinical researchers on the latest advances in the biology and treatment of bone marrow-based malignancy. On the biological side, authors review characteristics of malignant cells and describe the roles played by oncogenic changes, chromosomal anomalies, Kaposi's sarcoma, and cytokines. New epidemiological findings and prognostic factors are also analyzed. On the clinical side, the authors detail conventional treatment regimens and discuss newer experimental approaches involving immunologic targeting, inhibitors of drug resistance, and antitumor agents. Readership for the book includes hematologists, researchers, and drug developers. Annotation © 2004 Book News, Inc., Portland, OR

Doody Review Services

Reviewer:Seema Singhal, MD(Northwestern University Feinberg School of Medicine)
Description:This is a book on myeloma and has not described closely-related diseases such as amyloidosis, Waldenstrom's macroglobulinemia, light and heavy chain deposition disease, and Castleman's disease.
Purpose:The purpose of the book is to provide an authoritative, comprehensive and detailed interpretation of published studies related to myeloma. These are worthy objectives but have been addressed by at least three other books in the field, and are met only partially in this book because of omission of related diseases as well as detailed information on subjects such as radiological aspects, neurological complications, and newer therapies such as thalidomide.
Audience:The book is written for physicians and scientists with an interest in myeloma. The audience is appropriate. The editor and several of the contributors are credible authorities in the field.
Features:The book covers most of the clinical aspects pertaining to myeloma and its complications, several of the laboratory and research aspects, and many of the treatment aspects. Absence of detailed information on several important practical aspects detract from the comprehensiveness of the book. A book published in 2004 should have significant details on thalidomide and bortezomib because of the importance of these agents in myeloma.
Assessment:The attraction of the book is its brevity compared to other books covering the subject. However, the absence of details on some subjects and lack of coverage of other plasma cell dyscrasias is an important shortcoming.

Features A Comprehensive Review Of Advances In The Biology And Treatment Of Myeloma; Examination Of Epidemiolgical Findings And Prognostic Factors; Thorough Analysis Of Conventional Treatment Regimens; Discussion Of Immunologic Targeting, Drug Resistance Inhibitors, And Antitumor Agents; And Insights That Can Be Directly Applied To The Laboratory And The Clinic. Diagnosis Of Muliple Myeloma / Robert A. Kyle And Daniel E. Bergsagel -- Epidemiology Of Multiple Myeloma And Related Disease / Brian G. M. Durie -- Characterization Of The Myeloma Clone / Robert A. Vescio And James R. Berenson -- Oncogenesis Of Multiple Myeloma / Johannes Drach, Sonja Seidl, Jutta Ackermann, And Hannes Kaufmann -- Cytokines In Multiple Myeloma / John De Vos And Bernard Klein -- Monoclonal Gammopathy Of Undetermined Significance / Robert A. Kyle -- Tumor Burden : Staging And Prognostic Factors / Douglas E. Joshua -- Treatment Of Multiple Myeloma / Meletios A. Dimopoulos And Robert A. Kyle. Dose-intensive Therapy With Autologous Stem Cell Transplantation For Patients With Multiple Myeloma / Jean-luc Harousseau, Michel Attal, And Gary J. Schiller -- Allogeneic Transplantation In Multiple Myeloma / Gösta Gahrton, Kenneth C. Anderson, And William Bensinger -- Immunological Approaches To Multiple Myeloma / Hakan Mellstedt, Maurizio Bendandi, Anders Österborg, And Larry Walsh -- Remission Maintenance In Multiple Myeloma / Heinz Ludwig And Niklas Zojer -- Myeloma Bone Disease / James R. Berenson. Renal Diseases Associated With Multiple Myeloma And Related Plasma Cell Dyscrasias / Alan Solomon, Deborah T. Weiss, And Guillermo A. Herrera -- Pathogenesis And Treatment Of Anemia / Heinz Ludwig And Anders Österborg -- New Therapeutic Approaches To Myeloma / Terry H. Landowski, William S. Dalton, And Sydney E. Salmon. Edited By James R. Berenson. Includes Bibliographical References And Index. Bone marrow-based malignancy is becoming more commonplace. There have also been major advances in the diagnosis, pathogenesis, and treatment of this common tumor type. In Biology and Management of Multiple Myeloma, expert physicians and clinical researchers summarize and explain the recent advances in the biology and treatment of this common B-cell tumor. On the biological side, the authors review the many important, clinically relevant discoveries that have been made in the last few years. They show the characteristics of the malignant cell and describe the significant roles played by oncogenic changes, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic factors are also analyzed. On the clinical side, the authors provide a comprehensive review of conventional treatment regimens, as well as a discussion of newer experimental approaches involving immunologic targeting, inhibitors of drug resistance, and antitumor agents. The role of high-dose therapy is also discussed, along with the treatment of such complications as renal disease, anemia, and bone disease. Comprehensive and authoritative, Biology and Management of Multiple Myeloma offers both clinicians and researchers a thoroughly up-to-date understanding of the new biology that can be directly applied not only to future laboratory studies, but also to the optimal treatment of myeloma patients today Provides an authoritative, comprehensive, and detailed interpretation of published studies related to this B cell malignancy. Written by a group of international experts, the book provides insights into the newest breakthroughs from the basic pathogenesis to the clinical aspects of multiple myeloma. The first part is devoted to the biology of myeloma where important discoveries have been made in the last few years, many of which are clinically relevant. The important roles of oncogenic, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines are described in detail. New epidemiological findings and prognostic factors are analyzed in separate chapters. A thorough analysis of conventional treatment regimens is provided, as well as discussion of newer experimental approaches involving immunological targeting, inhibitors of drug resistance proteins, and new anti-tumor agents. The role of high-dose therapy is discussed and divided into separate chapters devoted to allogeneic and autologous transplantation. The controversial role of interferon is discussed in a chapter detailing analysis of published trials. This book will provide the reader with a thorough understanding of where myeloma is in the clinical research realms. CURRENT CLINICAL ONCOLOGY......Page 3 BIOLOGY AND MANAGEMENT OF MULTIPLE MYELOMA......Page 4 Dedication......Page 6 Preface......Page 8 Contents......Page 10 Contributors......Page 12 1 Diagnosis of Multiple Myeloma......Page 14 2 Epidemiology of Multiple Myeloma and Related Disease......Page 26 3 Characterization of the Myeloma Clone......Page 50 4 Oncogenesis of Multiple Myeloma......Page 68 5 Cytokines in Multiple Myeloma......Page 82 6 Monoclonal Gammopathy of Undetermined Significance......Page 106 7 Tumor Burden: Staging and Prognostic Factors......Page 140 8 Treatment of Multiple Myeloma......Page 150 9 Dose-Intensive Therapy With Autologous Stem Cell Transplantation for Patients With Multiple Myeloma......Page 172 10 Allogeneic Transplantation in Multiple Myeloma......Page 196 11 Immunological Approaches to Multiple Myeloma......Page 218 12 Remission Maintenance in Multiple Myeloma......Page 236 13 Myeloma Bone Disease......Page 264 14 Renal Diseases Associated With Multiple Myeloma and Related Plasma Cell Dyscrasias......Page 294 15 Pathogenesis and Treatment of Anemia......Page 316 16 New Therapeutic Approaches to Myeloma......Page 332 Index......Page 368 "Biology and Management of Multiple Myeloma offers both clinicians and researchers a thoroughly up-to-date understanding of the new biology that can be directly applied not only to future laboratory studies, but also to the optimal treatment of myeloma patients today."--BOOK JACKET. Multiple myeloma (MM) is a neoplastic disorder characterized by the proliferation of a single clone of plasma cells derived from B cells in the bone marrow.