Biologics to Treat Substance Use Disorders : Vaccines, Monoclonal Antibodies, and Enzymes

This book is a scientific compendium documenting the state of the art in the discovery and development of vaccines, monoclonal antibodies, and enzymes for the treatment of Substance Use Disorders (SUDs). The book gives detailed consideration to some of the most cutting edge topics in addiction medicine, including vaccines for nicotine, cocaine, heroin, and methamphetamine dependence; monoclonal antibodies against cocaine, methamphetamine, and phencyclidine; and the enzymes butyrylcholinesterase and cocaine esterase. In addition, the text covers a wide range of new strategies designed to optimize the development and efficacy of biologics. Unlike any other resource, this book reviews how biologics offer exciting new therapeutic opportunities for various psychiatric conditions. Written by experts in the field, __Biologics to Treat Substance Use Disorders__ is as an authoritative reference for psychiatrists, psychologists, and all other medical professionals working with patients suffering from Substance Use Disorders. Front Matter....Pages i-xvi Introduction: Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes....Pages 1-4 Front Matter....Pages 5-5 Therapeutic Vaccines for Treating Nicotine Addiction....Pages 7-24 Vaccines for Treating Cocaine Use Disorders....Pages 25-36 Vaccines for Opioid Addiction....Pages 37-63 Vaccines for Methamphetamine Use Disorder....Pages 65-74 Cocaine and HIV Infection....Pages 75-103 Front Matter....Pages 105-105 Monoclonal Antibodies....Pages 107-108 Anti-cocaine Monoclonal Antibodies....Pages 109-117 Discovery and Development of an Anti-methamphetamine Monoclonal Antibody for Use in Treating Methamphetamine Abuse....Pages 119-142 Front Matter....Pages 143-143 Enzyme-Based Cocaine Pharmacotherapies: Current Status and Projections for the Future....Pages 145-166 Viral Gene Transfer of Enzymes....Pages 167-185 Cocaine Hydrolases Designed from Butyrylcholinesterase....Pages 187-225 Front Matter....Pages 227-227 Adenovirus-Based Vaccines for the Treatment of Substance Use Disorders....Pages 229-248 Nanoparticle-Based Nicotine Vaccine....Pages 249-278 Exploration of DNA Nanostructures for Rational Design of Vaccines....Pages 279-293 Adjuvants for Substance Abuse Vaccines....Pages 295-307 Skin Vaccination Against Nicotine Addiction....Pages 309-325 Hapten Design for Anti-addiction Vaccine Development....Pages 327-365 B Cell Mechanisms Underlying Vaccine Efficacy Against Drugs of Abuse....Pages 367-393 Front Matter....Pages 395-395 Practical Considerations for the Development of Vaccines Against Drugs of Abuse....Pages 397-424 Front Matter....Pages 395-395 Ethical Considerations of Biologics to Treat Substance Use Disorders....Pages 425-437 Back Matter....Pages 439-453 Ivan D. Montoya, Editor. Includes Bibliographical References And Index.