Biological magnetic resonance. Vol. 33 Future Directions in Metalloprotein and Metalloenzyme Research

This book covers the latest developments in metalloenzymes, including characterizing metal bridging in proteins and peptides, copper(II) complexes of marine peptides, high-spin Co(II) in model and metalloprotein systems to enzymes such as the molybdenum-containing enzymes, CW and pulse EPR of cytochrome P450 enzymes and the radical S-adenosylmethionine FeS family. In the previous two related volumes in the Biological Magnetic Resonance series, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine and Metals in Biology:Applications of High-Resolution EPR to Metalloenzymes, topics covered included high-resolution EPR methods, iron proteins, nickel and copper enzymes, metals in medicine, iron–sulfur cluster-containing proteins, and molybdenum enzymes. In this volume, new developments in these areas are covered in detail and new areas that have emerged are also detailed. This is an ideal book for graduate students and researchers working in the fie lds of high-resolution EPR, metalloenzymes, and metals in biology. Front Matter ....Pages i-xi An Isotopic Dilution Strategy for Characterisation of Paramagnetic Metal Bridging of Proteins and Peptides (Simon C. Drew)....Pages 1-12 Structures, Electronics and Reactivity of Copper(II) Complexes of the Cyclic Pseudo-Peptides of the Ascidians (Peter Comba, Annika Eisenschmidt)....Pages 13-32 Paramagnetic Resonance of High-Spin Co(II) in Biologically-Relevant Environments: Models to Metalloproteins (Robert R. Baum, Christopher D. James, David L. Tierney)....Pages 33-54 EPR Spectroscopy on Mononuclear Molybdenum-Containing Enzymes (Luisa B. Maia, Isabel Moura, José J.G. Moura)....Pages 55-101 CW and Pulse EPR of Cytochrome P450 to Determine Structure and Function (Joshua S. Harbort, James J. De Voss, Jeanette E. Stok, Stephen G. Bell, Jeffrey R. Harmer)....Pages 103-142 Characterization of Radical S-adenosylmethionine Enzymes and Intermediates in their Reactions by Continuous Wave and Pulse Electron Paramagnetic Resonance Spectroscopies (Alexey Silakov, Nicholas D. Lanz, Squire J. Booker)....Pages 143-186 Back Matter ....Pages 187-191 "This book covers the latest developments in metalloenzymes, including characterizing metal bridging in proteins and peptides, copper(II) complexes of marine peptides, high-spin Co(II) in model and metalloprotein systems to enzymes such as the molybdenum-containing enzymes, CW and pulse EPR of cytochrome P450 enzymes and the radical S-adenosylmethionine FeS family. In the previous two related volumes in the Biological Magnetic Resonance series, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine and Metals in Biology:Applications of High-Resolution EPR to Metalloenzymes, topics covered included high-resolution EPR methods, iron proteins, nickel and copper enzymes, metals in medicine, iron-sulfur cluster-containing proteins, and molybdenum enzymes. In this volume, new developments in these areas are covered in detail and new areas that have emerged are also detailed. This is an ideal book for graduate students and researchers working in the fields of high-resolution EPR, metalloenzymes, and metals in biology"--Back cover