Biological Effects of 224Ra : Benefit and Risk of Therapeutic Application Proceedings of the Second Symposium at Neuherberg/München, September 20–21, 1976

Under An Association Contract Linking The Co~ission Of The European Communities And The Gesellschaft Fur Strahlen Und Umweltforschung Mbh, A Research Programme On The Patho Genesis Of Somatic Radiation Damage Has Been Under Way For A Number Of Years. Experimental Research On Long-term Radiation Effects Following The Incorporation Of Bone-seeking Radionuclides And An Epidemiological Study Of The Conse Quences For Patients Treated With 224ra For Therapeutical Reasons Have Been Among The Main Features Of The Work. The Research Carried Out On Tumor Induction In The Low Dose Range And For Low Dose Rates Is Particularly Important As Regards Assessing The Radiation Hazard To Man. The Second Symposium On The Biological Effects Of 224ra, Held At Neuherberg, Provided A Welcome Opportunity To Take Stock Of What Has Been Achieved So Far And To Discuss The Own Research Efforts In An International Setting. The Dis Cussions Focussed On Two Topical Aspects Of Radiation Protection. One Aspect Was The Long-term Effects Of High-let Ionizing Radiations On Man And The Quantitative Data Involved In Risk Assessment At Low Doses. The Epidemiological Studies And Experimental Research Carried Out Under The Association Contract Should Provide Facts And Figures For An Objective Assessment Of The Radiation Hazards From Incorporated Radio Nuclides, Which Is One Of The Fundamental And Controversial Problems Of The Nuclear Energy Debate. Front Matter....Pages i-viii Preface....Pages 1-4 On the scientific work of Fritz Schales....Pages 5-6 Opening Address: W. Gössner....Pages 7-10 Zur Klinik der ankylosierenden Spondylitis (Morbus Bechterew)....Pages 11-18 Pathology and radiology of ankylosing spondylitis....Pages 19-20 Indication for 224 Ra-therapy in ankylosing spondylitis (Morbus Struempell-Bechterew-Marie)....Pages 21-29 Problems and results of a new follow-up study - 224 Ra in adult ankylosing spondylitis patients....Pages 30-36 Addendum to the previous paper: risk to bone from present 224 Ra therapy....Pages 37-43 Quality control in the production process and purity of 224 Ra for injection....Pages 44-49 Therapeutical results in a follow-up study on 224 Ra-therapy of ankylosing spondylitis....Pages 50-59 X-Ray therapy in the treatment of ankylosing spondylitis....Pages 60-69 Radiosynoviorthesis: local treatment of rheumatoid arthritis....Pages 71-78 Comparison of the efficacy of 224 Ra and other radio-isotopes in the treatment of rheumatoid arthritis....Pages 79-86 Experimental data on the injection of 224 Ra into the kneejoint of rats and rabbits....Pages 87-94 Intravenous injection of 224 Ra in morbus Paget....Pages 95-101 Clinical experiences concerning late effects and risks of 224 Ra....Pages 102-108 Osteogenic sarcomas in mice after 224 Ra or 226 Ra administrations....Pages 109-119 Biological effects of 224 Ra and 226 Ra and their relative radiotoxicity in mice....Pages 120-134 The Dependence of late effects in mice on the temporal distribution of skeletal α-doses from 224 Ra and 227 Ra....Pages 135-148 Histopathology of early effects of 224 Ra on bone tissue....Pages 149-157 Expression of type C RNA virus particles in 224 Ra-induced osteosarcomas....Pages 158-167 Bone sarcoma to man from 224 Ra, 226 Ra, and 239 Pu....Pages 168-181 Problems in radiological protection involving α-emitters in bone....Pages 182-200 A model for the induction of bone cancer by 224 Ra....Pages 201-209 Methodological aspect of epidemiological inquiries in clinical radiobiology....Pages 210-211 Notre expérience du 224 Ra dans le traitement de la spondylarthrite ankylosante....Pages 212-214 Erratum to: Osteogenic sarcomas in mice after 224 Ra or 226 Ra administrations....Pages 237-237 Erratum to: Problems in radiological protection involving α-emitters in bone....Pages 237-237 Back Matter....Pages 215-236