Biological and Medical Research in Space : An Overview of Life Sciences Research in Microgravity

This book is aimed at the wide community of scientists whose research might benefit from consideration of gravitational and space biology as another dimension of environmental interference on their work. It is important to stress the numerous molecular, cellular and physiological mechanisms, in all forms of life, which are influenced by, or eventually dependent on, gravity or radiation. The book brings together results from space flight and ground-based experiments in the various life science disciplines which are scattered in the literature and often published in sources not easily available to the general scientific community. Some of the results obtained are apparently contradictory of predictions of classical hypotheses and thus deserve widespread attention. The presentation emphasizes, a comprehensive and critical review of available data, aiming not only to improve access to the information, but to comment also on its credibility and place it in proper context. This timely review will also benefit those engaged in design, assessment and execution of life science experiments in space. Life Science studies in space were initially driven by the need to explore how man could survive spaceflight conditions; the effects of being launched un­ der high accelerations, exposed to weightlessness and radiation for different periods of time, and returned to Earth in safety. In order to substantiate the detailed knowledge of potentially adverse effects, many model experiments were launched using organisms which ranged from bacteria, plants, inverte­ brates, rodents and primates through to man. Although no immediate life threatening effects were found, these experiments can be considered today as the precursors to life science research in space. Many unexplained effects on these life forms were attributed to the condition of weightlessness. Most of them were poorly recorded, poorly published, or left simply with anecdotal information. Only with the advent of Skylab, and later Spacelab, did the idea emerge, and indeed the infrastructure permit, weightlessness to be considered as an ex­ tended tool for research into some fundamental mechanisms or processes as­ sociated with the effect of gravity on organisms at all levels. The initial hy­ pothesis to extrapolate from hypergravity through 1 x g to near 0 x g effects could no longer be retained, since many of the experiment results were seen to contradict the models or theories in the current textbooks of biology and physiology. The past decade has been dedicated primarily to exploratory research. This book provides a critical review of the whole Space Life Sciences research field, offering a very timely overview of the field as the initial exploratory research phase comes to an end to be replaced by the in-depth experimental programmes which will become more accessible towards the end of the century in the era of International Space Station Alpha. Chapters 1 to 7 are scientific reviews which have been prepared by recognized experts in Cell Biology, Human Physiology, Radiation Biology and Exobiology.

Addresses neurosensory & sensory-motor functions/bone & space flight: an overview/exobiology/radiation biology/etc.

Front Matter....Pages I-XII Gravitational and space biology at the cellular level....Pages 1-106 Physiology of cardiovascular, respiratory, interstitial, endocrine, immune, and muscular systems....Pages 107-153 Kidney function and fluid homeostasis....Pages 154-177 Neurosensory and sensory-motor functions....Pages 178-258 Bone and space flight: an overview....Pages 259-299 Radiation biology....Pages 300-367 Exobiology....Pages 368-431 National and international space life sciences research programmes 1980 to 1993 - and beyond....Pages 432-541 Back Matter....Pages 542-569