Biological Activities of Steroids in Relation to Cancer. Proceedings of a Conference Sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, U. S. Department of Health, Education and Welfare

Content: Front Matter , Page iii Copyright , Page iv Dedication , Page v Contributors , Pages vii-x Preface , Pages xi-xii , GREGORY PINCUS, ERWIN P. VOLLMER Steroids, Growth, and Cancer , Pages 1-8 , CHARLES HUGGINS Some Recent Advances in Steroid Chemistry , Pages 9-24 , JOSEF FRIED Physiology and Pharmacology of Steroids Affecting Tumor Growth , Pages 25-59 , VICTOR A. DRILL The Binding of Steroid Hormones by Plasma Proteins , Pages 61-76 , WILLIAM H. DAUGHADAY, IDA KOZAK MARIZ The Effects of Steroids on the Levels of the Plasma 17-Hydroxycorticosteroids and the Serum Protein-Bound Iodine , Pages 77-92 , ANNE C. CARTER, ELAINE BOSSAK FELDMAN, ELEANOR Z. WALLACE The Metabolism of Dehydroisoandrosterone , Pages 93-110 , R. VANDEWIELE, S. LIEBERMAN Recent Studies on Estrogen Metabolism , Pages 111-127 , LEWIS L. ENGEL Biochemical Parameters of Estrogen Action, , Pages 129-145 , GERALD C. MUELLER Enzymatic Transport of Hydrogen by Estrogenic Hormones , Pages 147-160 , H.G. WILLIAMS-ASHMAN, SHUTSUNG LIAO, P. TALALAY Fate of Steroid Estrogens in Target Tissues , Pages 161-178 , ELWOOD V. JENSEN, HERBERT I. JACOBSON The Prostate As a Target Organ for Steroids , Pages 179-188 , WILLIAM WALLACE SCOTT Effect of Steroids on Calcium Dynamics , Pages 189-197 , EUGENE EISENBERG The Effect of Estrogen Therapy on Incorporation of Formate-C 14 into Human Breast Cancer in Vitro , Pages 199-209 , RICHARD J. WINZLER, HOWARD H. SKY-PECK, S.G. TAYLOR III, SYDNEY KOFMAN IV. - Studies of Hormone Dependency Employing Interstitial Cell Testicular Tumors of Mice , Pages 211-223 , ROBERT A. HUSEBY Steroid-Responsive Neoplasms in Rats and Mice , Pages 225-256 , W.F. DUNNING Steroids and Experimental Mammary Cancer , Pages 257-305 , E. MYLES GLENN, S. LEE RICHARDSON, BARBARA J. BOWMAN, STANLEY C. LYSTER Steroid Effects on Heterologously-Transplanted Human Tumors , Pages 307-330 , GEORGE W. WOOLLEY, JOHN J. HARRIS, PHILIP C. MERKER, JOY E. PALM, MORRIS N. TELLER Steroid-Induced Tumors in Animals , Pages 331-342 , O. MÜHLBOCK Evaluation of Endocrine Ablative Surgery in the Treatment of Mammary Carcinoma: A Preliminary Study on Survival , Pages 343-354 , SAMUEL G. TAYLOR III, CHARLES P. PERLIA Testosterone Propionate Therapy of Breast Cancer—A Report for the Cooperative Breast Cancer Group , Pages 355-362 , ALBERT SEGALOFF Hormonal Therapy of Breast Cancer A Summary of Experience with Newer Steroids , Pages 363-383 , CHESTER B. ROSOFF Evaluation of 4-Androstene-3β,17β-diol Diacetate in the Treatment of Advanced Breast Cancer , Pages 385-388 , KENNETH B. OLSON, FRED J. ANSFIELD Δ 1 -Testololactone, Androsterone, and 5α-Androstane-3α, 17β-diol Dipropionate in the Treatment of Advanced Breast Cancer , Pages 389-392 , ALBERT SEGALOFF, J.B. WEETH, P.J. MURISON, E.L. RONGONE An Evaluation of 9α-Bromo-11-ketoprogesterone in the Treatment of Metastatic Breast Carcinoma , Pages 393-395 , IRA S. GOLDENBERG, MARK A. HAYES Comparison of the Antitumor Effects of 17α-Methyl-19-Nortestosterone and Testosterone Propionate in Advanced Mammary Carcinoma, , Pages 397-399 , ANNE C. CARTER, ELAINE BOSSAK FELDMAN, GEORGE C. ESCHER The Cooperative Study Program in Therapy of Advanced Prostatic Cancer , Pages 401-412 , HERBERT BRENDLER The Sex Hormones and Cortisone in the Treatment of Inoperable Bronchogenic Carcinoma , Pages 413-426 , JULIUS WOLF, PAUL SPEAR, RAYMOND YESNER, MARY ELLEN PATNO Clinical Observations on the Effect of Progesterone in the Treatment of Metastatic Endometrial Carcinoma, , Pages 427-443 , RITA M. KELLEY, WILLIAM H. BAKER Steroid Metabolism in Endocrine Tumors , Pages 445-461 , RALPH I. DORFMAN Regression of Adrenal Cancer and Suppression of Adrenal Function in Man by o,p′-DDD , Pages 463-475 , D.M. BERGENSTAL, M.B. LIPSETT, R.H. MOY, ROY HERTZ Serum Proteins in Breast Carcinoma: Effects of Androgen Therapy , Pages 477-482 , M.J. BRENNAN, W.L. SIMPSON Cellular Prognostic Factors in Breast Cancer Hormone Therapy , Pages 483-491 , THOMAS C. HALL, MARGARIDA M. DEDERICK, HANS B. NEVINNY, RITA M. KELLEY Glossary , Pages 493-500 Author Index , Pages 501-513 Subject Index , Pages 514-530 Biological Activities of Steroids in Relation to Cancer covers the proceedings of the conference sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, and the U.S. Department of Health, Education and Welfare. The text focuses on the influence of steroids on medical approaches to the cure of cancer, including steroid chemistry, estrogen metabolism, and mammary cancer. The selection first offers information on steroids growth and cancer, advances in steroid chemistry, and the physiology and pharmacology of steroids affecting tum ..