Bioinorganic Chemistry : An Inorganic Perspective of Life

Bioinorganic chemistry is primarily concerned with the role of metal atoms in biology and is a very active research field. However, even though such important structures of metalloenzymes are known, as the MoFeCo of nitrogenase, Cu or Mn superoxide dismutase and plastocyanin, the synthetic routes to the modelling of such centers remains a matter of acute scientific interest. Other metalloenzymes, such as the Mn center of the oxygen evolving complex of PSII, are still the focus of in-depth examination, both spectroscopic and structural. Another area of concern is the interaction between drugs and metals and metal ion antagonism. Understanding the chemistry of metal ions in biological systems will bring benefits in terms of understanding such problems as biomineralization and the production of advanced materials by micro-organisms. The 29 contributions to __Bioinorganic Chemistry: An Inorganic Perspective of Life__ give an excellent summary of the state of the art in this field, covering areas from the NMR of paramagnetic molecules to the use of lanthanide porphyrins in artificial batteries. Front Matter....Pages i-xx Front Matter....Pages xxi-xxi Methane Monooxygenase....Pages 1-12 The Coordination Chemistry of Iron in Biological Transport and Storage; Iron Removal in Vivo ....Pages 13-24 Siderophore-Mediated Iron Transport in Microbes....Pages 25-37 On the Mechanism of Epoxidation and Hydroxylation Catalyzed by Iron Porphyrins. Evidence for Non-Intersecting Reaction Pathways....Pages 39-47 Self-Assembly, Catalysis and Electron Transfer with Metalloporphyrins in Phospholipid Membranes....Pages 49-56 Mechanistic Studies on the Binuclear Fe Enzymes Ribonucleotide Reductase and Purple Acid Phosphatase....Pages 57-65 Structure and Reactivity of the Blue Copper Proteins....Pages 67-76 Copper-Zinc Superoxide Dismutase: Mechanistic and Biological Studies....Pages 77-91 NMR of Paramagnetic Molecules: A Contribution to the Understanding of Enzymatic Mechanisms....Pages 93-104 Magnetic and EPR Studies of Superoxide Dismutases (SOD): Electronic Structure of the Active Sites for the (Copper-Zinc)SOD, its Cobalt Substituted Derivative and the Iron(III)SOD from E. Coli ....Pages 105-111 Mechanism of Action of Thiamin Enzymes Role of Metal Ions....Pages 113-128 Front Matter....Pages 129-129 Platinum Anticancer Drugs....Pages 131-140 NMR Spectroscopic Structure Determination of Metal Ion — Oligonucleotide Complexes — The Results of Sequence-Selective Binding Studies....Pages 141-153 Metal Ion-Coordinating Properties in Solution of Purine-Nucleoside 5’-Monophosphates and Some Analogues....Pages 155-178 Metal-Nucleobase Chemistry: Coordination, Reactivity, and Base Pairing....Pages 179-199 DNA Cleavage by Cationic Metalloporphyrins....Pages 201-208 The Role of Metal Ions in Biological Systems and Medicine....Pages 209-218 The Interaction of Heavy Metal Ions with DNA....Pages 219-235 Thermodynamics and Kinetics of Competing Redox Processes During DNA Cleavage: Reactivity-Based Selectivity....Pages 237-243 Front Matter....Pages 245-245 Mo/S Chemistry and Its Importance in Enzymatic Catalysis....Pages 247-274 Front Matter....Pages 245-245 Use of De Novo Designed Peptides for the Study of Metalloproteins and Enzymes....Pages 275-285 Modeling the Chemistry and Properties of Multinuclear Manganese Enzymes....Pages 287-298 Manganese-Proteins and -Enzymes and Relevant Trinuclear Synthetic Complexes....Pages 299-320 Catalytic Oxidation of Pollutants by Ligninase Models Based on Metalloporphyrins and Metallophthalocyanines....Pages 321-331 Nickel Coordination Chemistry with Oxothiolate Ligands and Its Relevance to Hydrogenase Enzymes....Pages 333-348 Artificial Batteries with Lanthanide Porphyrins?....Pages 349-357 Novel Transition Metal Heteropolymetalates and Derivatives: Structural Chemistry, Biological and Catalytic Relevance....Pages 359-370 Purple Acid Phosphatases and Catechol Oxidase and their Model Compounds. Crystal Structure Studies of Purple Acid Phosphatase from Red Kidney Beans....Pages 371-384 Molybdenum — Copper Antagonism....Pages 385-400 Back Matter....Pages 401-415