Bioinformatics - From Genomes to Therapies: Volume 1: The Building Blocks: Molecular Sequences and Structures; Volume 2: Getting at the Inner Workings: ... Volume 3: The Holy Grail: Molecular Function

Once again, Thomas Lengauer has succeeded in creating a comprehensive and immensely useful bioinformatics resource that meets even the high standards of professionals in the pharmaceutical and medical sector. By extending the classical application areas of bioinformatics to the most recent approaches in analyzing molecular networks and in predicting molecular function, this handbook serves as a first-stop resource for every bioinformatics user in the life sciences. With contributions by more than 40 of the world's leading bioinformaticians, it is unrivalled in terms of scientific authority and accuracy. The best single information source available, written by professionals for professionals. Cover......Page 1 Frontmatter......Page 2 Contents......Page 9 Preface......Page 57 List of Contributors......Page 60 1 Bioinformatics -- From Genomes to Therapies......Page 69 2 Bioinformatics Support for Genome-Sequencing Projects......Page 93 3 Sequence Alignment and Sequence Database Search......Page 124 4 Phylogeny Reconstruction......Page 150 5 Finding Protein-coding Genes......Page 196 6 Analyzing Regulatory Regions in Genomes......Page 226 7 Finding Repeats in Genome Sequences......Page 263 8 Analyzing Genome Rearrangements......Page 300 9 Predicting Simplified Features of Protein Structure......Page 326 10 Homology Modeling in Biology and Medicine......Page 361 11 Protein Fold Recognition Based on Distant Homologs......Page 414 12 De Novo Structure Prediction: Methods and Applications......Page 452 13 Structural Genomics......Page 482 14 RNA Secondary Structures......Page 502 15 RNA Tertiary Structure Prediction......Page 553 16 Docking and Scoring for Structure-based Drug Design......Page 602 17 Modeling Protein–Protein and Protein–DNA Docking......Page 661 18 Lead Identification by Virtual Screening......Page 711 19 Efficient Strategies for Lead Optimization by Simultaneously Addressing Affinity, Selectivity and Pharmacokinetic Parameters......Page 765 20 Modeling and Simulating Metabolic Networks......Page 815 21 Inferring Gene Regulatory Networks......Page 866 22 Modeling Cell Signaling Networks......Page 887 23 Dynamics of Virus–Host Cell Interaction......Page 919 24 DNA Microarray Technology and Applications – An Overview......Page 957 25 Low-level Analysis of Microarray Experiments......Page 987 26 Classification of Patients......Page 1015 27 Classification of Genes......Page 1050 28 Proteomics: Beyond cDNA......Page 1079 29 Ontologies for Molecular Biology......Page 1116 30 Inferring Protein Function from Sequence......Page 1142 31 Analyzing Protein Interaction Networks......Page 1175 32 Inferring Protein Function from Genomic Context......Page 1232 33 Inferring Protein Function from Protein Structure......Page 1264 34 Mining Information on Protein Function from Text......Page 1306 35 Integrating Information for Protein Function Prediction......Page 1349 36 The Molecular Basis of Predicting Druggability......Page 1367 37 Comparative Genomics......Page 1387 38 Association Studies of Complex Diseases......Page 1427 Appendix A......Page 1475 39 Pharmacogenetics/Pharmacogenomics......Page 1479 40 Evolution of Drug Resistance in HIV......Page 1508 41 Analyzing the Evolution of Infectious Bacteria......Page 1547 42 Integrating Biological Databases......Page 1575 43 Visualization of Biological Data......Page 1622 44 Using Distributed Data and Tools in Bioinformatics Applications......Page 1676 45 Future Trends......Page 1700 Index......Page 1736 Name Index......Page 1776 Once Again, Thomas Lengauer Has Succeeded In Bringing Together The Big Themes And Big Names In Bioinformatics For An Unrivalled Survey Of The Field. With Its Focus On Bioinformatics Applications In Pharmaceutical And Biological Research, This Three-volume Handbook Is An Indispensible Resource For Scientists And Professionals In The Life Sciences. V. 1. The Building Blocks: Molecular Sequences And Structures -- V. 2. Getting At The Inner Workings: Molecular Interactions -- V. 3. The Holy Grail: Molecular Function. Edited By Thomas Lengauer. This Book Is A Substantially Expanded Sequel To The Book Bioinformatics - From Genomes To Drugs, That Appeared In 2002--p. Xxv. Includes Bibliographical References And Indexes.