Bioinformatics and Biomedical Engineering: 6th International Work-Conference, IWBBIO 2018, Granada, Spain, April 25–27, 2018, Proceedings, Part II (Lecture Notes in Computer Science (10814))

This two volume set LNBI 10813 and LNBI 10814 constitutes the proceedings of the 6th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2018, held in Granada, Spain, in April 2018. The 88 regular papers presented were carefully reviewed and selected from 273 submissions. The scope of the conference spans the following areas: bioinformatics for healthcare and diseases; bioinformatics tools to integrate omics dataset and address biological question; challenges and advances in measurement and self-parametrization of complex biological systems; computational genomics; computational proteomics; computational systems for modelling biological processes; drug delivery system design aided by mathematical modelling and experiments; generation, management and biological insights from big data; high-throughput bioinformatic tools for medical genomics; next generation sequencing and sequence analysis; interpretable models in biomedicine and bioinformatics; little-big data. Reducing the complexity and facing uncertainty of highly underdetermined phenotype prediction problems; biomedical engineering; biomedical image analysis; biomedical signal analysis; challenges in smart and wearable sensor design for mobile health; and healthcare and diseases. Preface Organization Contents – Part II Contents -- Part I Little-Big Data. Reducing the Complexity and Facing Uncertainty of Highly Underdetermined Phenotype Prediction Problems Know-GRRF: Domain-Knowledge Informed Biomarker Discovery with Random Forests Abstract 1 Introduction 2 New Method 2.1 Know-GRRF Algorithm 2.2 Relationship with RFF and GRFF 3 Results 3.1 Simulation 3.2 Radiation Data 3.3 Tuning Parameters 4 Discussion and Conclusion Acknowledgments References Sampling Defective Pathways in Phenotype Prediction Problems via the Fisher’s Ratio Sampler Abstract 1 Introduction 2 The Fisher’s Random Sampler 3 Results 4 Conclusions References Sampling Defective Pathways in Phenotype Prediction Problems via the Holdout Sampler Abstract 1 Introduction 2 From Regression Analysis to Sampling the Genetic Pathways 3 Results 4 Conclusions References Comparison of Different Sampling Algorithms for Phenotype Prediction Abstract 1 Introduction 2 Sampling Algorithms 3 Results 4 Conclusions References Biomedical Engineering Composite Piezoelectric Material for Biomedical Micro Hydraulic System Abstract 1 Introduction 2 Experimental Setup 2.1 Piezocomposite Synthesis 2.2 Mechanical Material Properties 2.3 Multilayer Structure 2.4 Dynamic Investigation of Composite Piezoelectric Material 2.5 Theoretical Calculations 3 Results and Discussion 4 Conclusions Acknowledgments References Trabecular Bone Score in Overweight and Normal-Weight Young Women Abstract 1 Introduction 2 Purpose 3 Materials and Methods 3.1 Subjects and Study Design 3.2 Anthropometrical Measurements 3.3 VO2 Max Assessment 3.4 Physical Activity 3.5 Daily Calcium Intake 3.6 Daily Protein Intake 3.7 Sleep Quality 3.8 Bone Measurements 3.9 Statistical Analysis 4 Results 4.1 Clinical Characteristics and Bone Variables of the Study Population 4.2 Correlations Between Clinical Characteristics and Bone Variables 4.3 Correlations Between TBS and BMC/BMD Values 4.4 Multiple Linear Regression Models 5 Discussion 6 Conclusion Conflicts of Interest References Sarcopenia and Hip Structure Analysis Variables in a Group of Lebanese Postmenopausal Women Abstract 1 Introduction 2 Methods 3 Results 4 Conclusion Conflicts of Interest References Feet Fidgeting Detection Based on Accelerometers Using Decision Tree Learning and Gradient Boosting Abstract 1 Introduction 2 Related Works 3 Datasets 3.1 Instrumented Shoe 3.2 Collected Dataset 4 Algorithms 4.1 Signal Processing 4.2 Feature Extraction 4.3 Models 5 Tests 5.1 Baseline Algorithm 5.2 Optimal Window Length 6 Results and Discussion 7 Conclusion References Matching Confidence Masks with Experts Annotations for Estimates of Chromosomal Copy Number Alterations 1 Introduction 2 Methods 2.1 Breakpoints Annotations 2.2 Modified Confidence Masks 3 Application 4 Results 5 Discussion 6 Conclusion References Using Orientation Sensors to Control a FES System for Upper-Limb Motor Rehabilitation Abstract 1 Introduction 2 Orientation Sensor-Based CCFES System 2.1 Architecture of the System 2.2 Joint Amplitude Estimation 2.3 FES Controller 3 Experimental Methods 3.1 Experimental Setup and Protocol 3.1.1 Execution of Bilateral Mirror Movements 3.2 Data Acquisition and Processing from Platform Simulink 3.3 Results 4 Conclusions Acknowledgments References A Real-Time Research Platform for Intent Pattern Recognition: Implementation, Validation and Application 1 Introduction 2 System Components 2.1 Bio-instrumentation Hardware 2.2 Real-Time Signal Acquisition System Based on xPC-Target 2.3 User Application 3 Evaluation Setup 3.1 Reference Signal Comparison 3.2 Decoding Wrist and Forearm Movements 4 Results 4.1 Reference Signal Comparison 4.2 Decoding Wrist and Forearm Movements 5 Conclusions and Future Work References Augmented Visualization and Touchless Interaction with Virtual Organs Abstract 1 Introduction 2 Building of the 3D Model of the Organs 3 Gestural Technologies 4 Interaction with Virtual Organs 5 Interaction with Medical Images 6 Conclusions and Future Work References Decreased Composite Indices of Femoral Neck Strength in Young Obese Women Abstract 1 Introduction 2 Methods 3 Results 4 Conclusion Conflicts of Interest References On the Use of Decision Trees Based on Diagnosis and Drug Codes for Analyzing Chronic Patients 1 Introduction 2 Data Set Description 3 Methods 4 Results 4.1 Experimental Setup 4.2 Decision Trees 5 Discussion and Conclusions References Biomedical Image Analysis Stochastic Geometry for Automatic Assessment of Ki-67 Index in Breast Cancer Preparations 1 Introduction 2 Method 2.1 Method Overview 2.2 Marked Point Process 2.3 Optimization 2.4 Ki-67 Scoring 3 Results 4 Conclusions References Detection Methods of Static Microscopic Objects Abstract 1 Introduction 2 Segmentation Methods Suitable for Static Object 2.1 Basic Thresholding 2.2 Region Growing 2.3 Watershed Segmentation 2.4 LBP Method 3 Designed Techniques of Segmentation for Ciliary Images 4 Conclusion Acknowledgement References Parkinson’s Disease Database Analysis of Stereotactic Coordinates Related to Clinical Outcomes Abstract 1 Introduction 2 Materials and Methods 3 Results 3.1 Variables Classification Accounting Medication 3.2 Variables Classification Without Medication 4 Discussion 5 Conclusion References Quantitative Ultrasound of Tumor Surrounding Tissue for Enhancement of Breast Cancer Diagnosis 1 Introduction 2 Materials and Methods 2.1 Data Collection 2.2 ROI Selection 2.3 Tissue Parameters 2.4 Classifiers Evaluation 3 Results 4 Discussion 5 Conclusions References A Texture Analysis Approach for Spine Metastasis Classification in T1 and T2 MRI 1 Introduction 2 Related Works 3 Materials and Methods 3.1 Data Preprocessing 3.2 Texture Feature Extraction 3.3 Classifier Learning 4 Experimental Results 4.1 Performance of Selected Models 5 Discussion and Conclusion References Parametric Variations of Anisotropic Diffusion and Gaussian High-Pass Filter for NIR Image Preprocessing in Vein Identification Abstract 1 Introduction 2 Anisotropic Diffusion 3 Gaussian High-Pass Filter 4 Single Parametric Experiments 4.1 Gaussian High-Pass Filtering 4.2 Anisotropic Diffusion Filtering 4.3 Combined Filtering 5 Conclusion and Discussion Acknowledgement References FLIR vs SEEK in Biomedical Applications of Infrared Thermography Abstract 1 Introduction 2 FLIR and SEEK Infrared Cameras in Biomedicine 3 Main Differences of FLIR One and SEEK Compact PRO 4 Experiments 4.1 Experiments with SEEK Compact PRO 4.2 Experiments with FLIR One 5 Conclusion and Discussion Acknowledgement References Advances in Homotopy Applied to Object Deformation 1 Introduction 2 Conventional Homotopy 2.1 Linear Mapping 2.2 Exponential Mapping 2.3 Polinomial Mapping 3 Parametric and Trascendental Functions-Based Mapping 3.1 Exponential Parametric Mapping 3.2 Sinusoidal Sine Mapping 3.3 Sinusoidal Cosine Mapping 3.4 Polynomial Coefficient Added 4 Quality Measure 5 Experimental Setup 5.1 Data Sets and Methods 5.2 Methods to be Compared 5.3 Parameter Settings 6 Results and Discussion 7 Final Remarks References Thermal Imaging for Localization of Anterior Forearm Subcutaneous Veins Abstract 1 Introduction 2 Forearm Thermography 2.1 Forearm Anatomy 2.2 Forearm NIR Imaging 2.3 Forearm IR-T Imaging 3 Segmentation 4 Directional Curvature Method 5 Experimental Results 6 Evaluation of the Results 7 Conclusions and Discussions Acknowledgment References Detection of Irregular Thermoregulation in Hand Thermography by Fuzzy C-Means Abstract 1 Introduction 2 Preparation 2.1 Design of Thermoregulation Experiment 2.2 Preprocessing of Pseudocolored Thermograms 2.3 Hand Segmentation 3 The Main Experiment 4 Results 5 Conclusions and Discussions Acknowledgment References Medical Image Classification with Hand-Designed or Machine-Designed Texture Descriptors: A Performance Evaluation Abstract 1 Introduction 2 Materials and Methods 2.1 Medical Image Datasets 2.2 Image Texture Descriptors 2.2.1 Local Binary Pattern, LBP 2.2.2 Local Ternary Pattern, LTP 2.2.3 Completed Local Binary Pattern, CLBP 2.2.4 Local Phase Quantization, LPQ 2.2.5 Rotation Invariant Co-occurrence of adjacent LBPs, RICLBP 2.2.6 Activations from pre-trained CNN 3 Experimental Setup and Results 4 Discussion and Conclusion Acknowledgements References Classification of Breast Cancer Histopathological Images Using KAZE Features Abstract 1 Introduction 2 Methods 2.1 BreaKHis Database 2.2 KAZE Based Bag of Features Classifier 2.3 Evaluation Metric 3 Results and Discussion 4 Conclusions Acknowledgement References Biomedical Signal Analysis Low Data Fusion Framework Oriented to Information Quality for BCI Systems Abstract 1 Introduction 2 Background 2.1 Joint Directors of Laboratories (JDL) Model 2.2 Information Quality Assessing 3 Proposed Framework 3.1 Information Quality and Performance Quality Characterization 3.2 Information Quality and Performance Evaluation 3.3 Validation 4 Conclusions Acknowledgments References New Parameter Available in Phonocardiogram for Blood Pressure Estimation 1 Introduction 2 Methodology 3 Results 4 Conclusion References Some False ECG Waves Detections Revised by Fractal Dimensions Abstract 1 Introduction 2 Fractal Dimension 3 Detection Algorithms 4 Results and Discussion 4.1 QRS Complexes 4.2 ST Segments 5 Conclusion References Challenges in Smart and Wearable Sensor Design for Mobile Health Reconstruction of Equivalent Electrical Sources on Heart Surface Abstract 1 Introduction 2 Algorithm of Reconstruction of Equivalent Electrical Sources 3 Interpolation of Torso Surface and the Surface Potential Map 4 Determination of Position and Size of Quasi-epicardium 5 Results of Reconstruction 6 Conclusion References WearIT - A Rapid Prototyping Platform for Wearables 1 Introduction 1.1 Goal 1.2 Layout 2 Requirements for WearIT 3 State of the Art 3.1 Prototyping Platforms 3.2 Comparison of Existing Platforms and WearIT 3.3 Related Work 4 Technical Implementation 4.1 Structure of the Components 4.2 Wearable Shields 4.3 Mainboard 4.4 Library 5 Conclusion and Future Work References A Review of Health Monitoring Systems Using Sensors on Bed or Cushion Abstract 1 Introduction 2 Commercial Devices 2.1 Pressure Maps Monitoring 2.2 Vital Sign Monitoring 3 Research Works 4 Conclusions References Textile Sensor Platform (TSP) - Development of a Textile Real-Time Electrocardiogram 1 Introduction 2 Related Work 2.1 Smart Textiles 2.2 Electrocardiogram 2.3 Bluetooth Low Energy 2.4 Fitness Tracker 3 Context 4 Requirements 5 Development 5.1 Selection of Textile, ECG Design and Conductive Material 5.2 Design of the Electrodes 5.3 Prototype 5.4 Microelectronic 6 Results 7 Conclusion References Sensor-Mesh-Based System with Application on Sleep Study Abstract 1 Introduction 2 State of the Art 3 System Architecture 3.1 Evolution of a System Design 3.2 Sensor Node Implementation 3.3 Data Collection 4 Results 5 Conclusion and Future Work References Wearable Pneumatic Sensor for Non-invasive Continuous Arterial Blood Pressure Monitoring 1 Introduction 2 Non-invasive ABP Monitoring 3 Local Compensation Pressure Measurement Method 4 Analysis of the BP Measurement Regimens 5 Conclusions References Healthcare and Diseases Gene-Gene Interaction Analysis: Correlation, Relative Entropy and Rough Set Theory Based Approach Abstract 1 Introduction 2 Literature Survey 3 Proposed Methodology 3.1 Correlation Measure 3.1.1 Pearson Correlation Coefficient 3.1.2 Spearman’s Ranked Correlation 3.1.3 Kendall-Tau Correlation 3.2 Relative Entropy Measure 3.3 Rough Set Theory 4 Experimental Results 4.1 Description of the Dataset 4.2 Platform Used 4.3 Results Using Correlation Measure 4.4 Results Using Entropy and Rough Set Measure 5 Conclusion and Future Scopes References A Transferable Belief Model Decision Support Tool over Complementary Clinical Conditions 1 Introduction 2 Data Fusion and Decision Making Within TBM 2.1 Knowledge Representation 2.2 Data Fusion 2.3 Pignistic Transformation 3 Methods 3.1 Heuristic Features Ranking 3.2 Bio Marker Data Fusion and Decision Making 4 Results and Discussion 4.1 Features Ranking Results and Biomarkers Selection 4.2 Decision Support Results 5 Conclusion References An Online Viewer of FHR Signal for Research, E-Learning and Tele-Medicine Abstract 1 Introduction 2 System Description 2.1 Conception 2.2 Features 3 Research Applications 3.1 Data Acquisition 3.2 Collaborative Research 3.3 Presentation 4 E-Learning Applications 5 Tele-Medicine Applications 5.1 Tele-Monitoring 5.2 Tele-Expertise 5.3 Integration on Hospital Information System 5.4 Sharing the Recording with Patient 6 Conclusion Acknowledgment References Modeling Spread of Infectious Diseases at the Arrival Stage of Hajj 1 Introduction 2 International Pilgrims Arrival 3 Epidemic Spread Modeling 3.1 Social Mixing and Contact Rate 3.2 Stochastic SEIR Agent-Based Model 4 Experimental Setting 5 Results and Discussion 5.1 Initial Epidemic 5.2 Epidemic Spread at Airport 5.3 Epidemic Spread at Makkah and Madinah 6 Conclusion References Exploring In-Game Reward Mechanisms in Diaquarium – A Serious Game for Children with Type 1 Diabetes Abstract 1 Introduction 2 Methods 3 Rewards in Games 4 Game Scenario 5 Game Outline 6 Rewards Applied in the Diaquarium 6.1 Positive Rewards 6.2 Negative Reinforcement 7 Discussion 8 Concluding Remarks References An “Awareness” Environment for Clinical Decision Support in e-Health Abstract 1 Introduction 2 Modeling Practice-Centred Awareness 3 Designing an Awareness Environment for Cross-Boundary Decision Support 3.1 CaDHealth Architecture 3.2 Implementation: A Scenario Example of Using CaDHealth 4 Conclusion References Correction to: Textile Sensor Platform (TSP) - Development of a Textile Real-Time Electrocardiogram Correction to: Chapter ““Textile Sensor Platform (TSP) - Development of a Textile Real-Time Electrocardiogram”” in: I. Rojas and F. Ortuño (Eds.): Bioinformatics and Biomedical Engineering, LNBI 10814, https://doi.org/10.1007/978-3-319-78759-6_33 Author Index