Biofunctional Surface Engineering

Successful biofunctional surface engineering will determine the future of medical devices such as orthopedic implants, stents, catheters, vaccine scaffolds, wound dressings, and extracorporeal circulation devices. Moreover, the biosensor and diagnostic chip technology will evolve rapidly due to the growing medical need for personalized medicine. A major drawback in these technologies is the need for terminally sterilized products. However, novel and safe technologies, including coupling, stabilization, and protection of effector molecules, enable terminal sterilization without functional lo The lack of effective sterilization techniques for biologics has spawned discussions about the reduction of regulatory requirements which might impose significant safety risks. On the other hand, novel and safe technologies enable the coupling, stabilization, and protection of effector molecules in a way that allows terminal sterilization without loss of function. This book provides a comprehensive overview on the state of the art and the future of "biofunctional surface engineering" and will be of major interest for all those working in the fields of medicine and medical devices Content: Preface Regulatory issues Sterilization of combination devices Polyelectrolyte monolayers (I) Polyelectrolyte monolayers (II) Surface modifications Three dimensional characterization of immobilized biomolecules Aptamers for biofunctionalization of stents Coating of implants with antibiotics Microneedles and nanopatchesfor vaccination Microchips for antibody binding analyses Biofunctionalized wound dressings Extracorporeal device for trapping circulating tumor cells Outlook