Biofilm Eradication and Prevention : A Pharmaceutical Approach to Medical Device Infections

"Biofilm Eradication and Preventions presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation"--Provided by publisher. Biofilm Eradication and Prevention s presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation. Content: Chapter 1 Introduction and Overview of Biofilm (pages 1–35): Chapter 2 Rationale for Biofilm Eradication from Modern Medical Devices (pages 36–72): Chapter 3 Pathogenesis of Device?Related Nosocomial Infections (pages 73–86): Chapter 4 Biofilm Resistance–Tolerance to Conventional Antimicrobial Agents (pages 87–115): Chapter 5 Analytical Techniques Useful to Study Biofilms (pages 116–151): Chapter 6 Biofilm?Related Infections in Ophthalmology (pages 153–183): Chapter 7 Biofilm?Related Infections in the Oral Cavity (pages 184–225): Chapter 8 Implications of Biofilm Formation in Chronic Wounds and in Cystic Fibrosis (pages 226–263): Chapter 9 Strategies for Prevention of Device?Related Nosocomial Infections (pages 265–336): Chapter 10 Liposomes as Drug Delivery Carriers to Biofilms (pages 337–358): Chapter 11 Polymer?Based Antimicrobial Delivery Carriers (pages 359–417): (Publisher-supplied data) Chapter 1. Introduction and Overview of Biofilm Chapter 2. Rationale for biofilm eradication from modern medical devices Chapter 3. Pathogenesis of device-related nosocomial infections Chapter 4. Biofilm resistance/tolerance to conventional antimicrobial agents Chapter 5. Analytical techniques useful to study biofilm Chapter 6. Biofilm-related infections in ophthalmology Chapter 7. Biofilm-related infections in oral cavity Chapter 8. Implications of biofilm formation in chronic wound and in cystic fibrosis Chapter 9. Strategies for prevention of device-related nosocomial infections Chapter 10. Liposomes as drug delivery carriers to biofilms Chapter 11. Polymer-based antimicrobial delivery carriers. Biofilm Eradication and Prevention presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers can take to limit this problem. The book first covers the development and characterization of biofilm on the surfaces of implanted or inserted medical devices.