Biocomputing 2011: Proceedings Of The Pacific Symposium Pacific Symposium On Biocomputing 2011 Kohala Coast, Hawaii, Usa, 3 - 7 January 2011

The Pacific Symposium on Biocomputing (PSB) 2011 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2011 will be held on January 3 - 7, 2011 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2011 will bring together top researchers from the US, Asia Pacific, and around the world to exchange research results and address pertinent issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics”. In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly evolving field. Computational methods integrating diverse biological and clinical data for translational science. Session introduction / Gurkan Bebek [und weitere]. Towards integrative gene prioritization in Alzheimer's disease / Jang Lee, Graciela Gonzalez. Systems biology analyses of gene expression and genome wide association study data in obstructive sleep apnea / Yu Liu [und weitere]. Finding most likely haplotypes in general pedigrees through parallel search with dynamic load balancing / Lars Otten, Rina Dechter. Dynamic, multi-level network models of clinical trials / Marco D. Sorani [und weitere]. Mining functionally relevant gene sets for analyzing physiologically novel clinical expression data / Sevin Turcan [und weitere]. Genotype phenotype mapping in RNA viruses - Disjunctive normal form learning / Chuang Wu, Andrew S. Walsh, Roni Rosenfeld -- Genome-wide association mapping and rare alleles : From population genomics to personalized medicine. Session introduction / Francisco M. De La Vega, Carlos D. Bustamante, Suzanne M. Leal. An application and empirical comparison of statistical analysis methods for associating rare variants to a complex phenotype / Vikas Bansal [und weitere]. Haplotype phasing by multi-assembly of shared haplotypes : Phase-dependent interactions between rare variants / Bjarni V. Halldorsson, Derek Aguiar, Sorin Istrail. An evaluation of power to detect low-frequency variant associations using allele-matching tests that account for uncertainty / Eleftheria Zeggini, Jennifer L. Asimit. Penalized regression for genome-wide association screening of sequence data / Hua Zhou [und weitere] -- Microbiome studies : understanding how the dominant form of life affects us. Session introduction / James Foster, Jason Moore. Estimating the number of species with catchall / John Bunge. A framework for analysis of metagenomic sequencing data / A. Murat Eren, Michael J. Ferris, Christopher M. Taylor. Visualization and statistical comparisons of microbial communities using R packages on phylochip data / S. Holmes [und weitere]. Human microbiome visualization using 3D technology / Jason H. Moore [und weitere]. Comparing bacterial communities inferred from 16S rRNA gene sequencing and shotgun metagenomics / Neethu Shah [und weitere] -- Multi-scale modelling of biosystems : from molecular to mesoscale. Session introduction / Julie Bernauer [und weitere]. Computational generation inhibitor-bound conformers of P38 map kinase and comparison with experiments / Ahmet Bakan, Ivet Bahar The Pacific Symposium on Biocomputing (PSB) 2011 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2011 was held on January 3 - 7, 2011 in Kohala Coast, Hawaii. Tutorials and workshops were offered prior to the start of the conference. PSB 2011 brought together top researchers from the US, Asia Pacific, and around the world to exchange research results and address pertinent issues in all aspects of computational biology. PSB is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics". In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly evolving field