Biochemistry of Schizophrenia and Addiction : In Search of a Common Factor

The main theme of this book concems the relationship, if any, between and addietion. Are they linked biochemieally? Is there a schizophrenia common factor for all addietions? We need to know whether the chemis­ try of addiction can help clarify the biochemistry of schizophrenia and vice versa. There is much anecdotal evidence that many sufferers from schizophrenia are addieted to smoking, are adversely affected by even small amounts of alcohol and do have their schizophrenie illness wor­ sened by street drugs. We would urge our readers to try to find correla­ tions between some of the findings described here on the biology of schizophrenia and what they read in the up-to-date chapters on addie­ tions. We would like to thank all the authors for the excellence of their work and for their cooperation and understanding of our needs and also, for the second time this year, to thank MTP Press for their willingness to pub­ lish a perhaps somewhat provocative book. We thank them for their humanity. Front Matter....Pages i-xvi Front Matter....Pages 1-1 The role of a prostaglandin E 1 deficiency in schizophrenia: interactions with dopamine and opiates....Pages 3-17 The pathogenesis of schizophrenia....Pages 19-38 Opiates, opioid peptides and their possible relevance to schizophrenia....Pages 39-51 The possible actions of peptides with opioid activity derived from pepsin hydrolysates of wheat gluten and of other constituents of gluten in the function of the central nervous system....Pages 53-76 Preliminary studies of the identification of brain peptides in relation to the genesis and expression of schizophrenia....Pages 77-84 The role of the dopamine system in schizophrenia....Pages 85-94 Front Matter....Pages 95-95 The relevance of immunopathology to research into schizophrenia....Pages 97-109 Some connections between immunoglobulins and schizophrenia....Pages 111-124 Antibodies to wheat proteins in schizophrenia: relationship or coincidence?....Pages 125-133 The effects of hormones on immune responses....Pages 135-152 Binding of chlorpromazine and HLA-A1 antibodies to human lymphocyte membranes....Pages 153-163 The possible role of prostaglandin E1 deficiency in the immunological abnormalities seen in schizophrenia....Pages 165-168 Immunological reaction of psychotic patients to fractions of gluten....Pages 169-176 Front Matter....Pages 177-177 β-endorphin and endoloxone: messengers of the autonomic nervous system for the conservation or expenditure of bodily resources and energy in anticipation of famine or feast....Pages 179-197 The pharmacology of tobacco smoking in relation to schizophrenia....Pages 199-207 Alcoholism and schizophrenia: A basic science approach....Pages 209-226 Opiate dependence and tolerance: a pharmacological analysis....Pages 227-263 Front Matter....Pages 265-265 Puerperal schizophrenia?....Pages 267-273 Front Matter....Pages 275-275 The digestion and absorption of dietary protein....Pages 277-285 Front Matter....Pages 287-287 Correlation between behavioural responses and cardiovascular changes and the central nervous mechanisms responsible for them....Pages 289-294 Front Matter....Pages 295-295 Schizophrenia and physical disease: a preliminary analysis of the data from the Oxford Record Linkage Study....Pages 297-318 Front Matter....Pages 319-319 Depot neuroleptics and tardive dyskinesia: a prospective study....Pages 321-325 Recent developments in the drug treatment of schizophrenia....Pages 327-336 Back Matter....Pages 337-344