Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects (Advances in Biochemistry in Health and Disease, 16)

"The strongest point of this book titled "Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects", is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Of particular importance is the fact that the aforementioned aspects are described in the book in a general section and in three different and important pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. The importance of these pathologies lays in the fact that, taken separately or together, they represent by far the leading cause of death in the world. Finally, all the chapters have been written by highly recognized authorities in the field of their investigations. At least to our knowledge, this is the first book with this characteristics in the field of oxidative stress." - Font no determinada Front Matter....Pages i-xi Front Matter....Pages 1-1 The Concept of Oxidative Stress After 30 Years....Pages 3-11 The Evolution of the Earth and Its Atmosphere....Pages 13-22 Biochemistry and Physiology of Heart Mitochondrial Nitric Oxide Synthase....Pages 23-35 Biochemistry of Nitric Oxide and Peroxynitrite: Sources, Targets and Biological Implications....Pages 37-48 Nitro-arachidonic Acid: Downstream Signaling and Therapeutics....Pages 49-77 Mitochondrial Transfer by Intercellular Nanotubes....Pages 79-93 Human Adaptation to Life at High Altitude....Pages 95-108 Front Matter....Pages 109-126 Role of Oxidative Stress in Subcellular Defects in Ischemic Heart Disease....Pages 127-127 Reduced Oxidative Stress as a Mechanism for Increased Longevity, Exercise and Heart Failure Protection with Adenylyl Cyclase Type 5 Inhibition....Pages 129-146 Regulation of Protein Nitrosylation by Thioredoxin 1....Pages 147-161 Thioredoxin Attenuates Post-ischemic Damage in Ventricular and Mitochondrial Function....Pages 163-175 Antioxidant Supplementation in Cardiovascular Disease and Hypertension....Pages 177-191 Oxidative Stress Influence in the Development of Pulmonary Arterial Hypertension....Pages 193-212 Redox Regulation of Vascular Remodeling....Pages 213-226 Mitochondrial Complex I Inactivation After Ischemia-Reperfusion in the Stunned Heart....Pages 227-243 Reactive Oxygen Species Are Involved in Myocardial Remote Ischemic Preconditioning....Pages 245-257 Inhaled Particulate Matter Leads to Myocardial Dysfunction....Pages 259-274 Front Matter....Pages 275-285 Neurovascular Coupling Mediated by Neuronal Derived-Nitric Oxide: Mechanisms in Health and Dysfunction with Impact on Aging and Alzheimer’s Disease....Pages 287-287 Oxidative Stress and Neurodegeneration....Pages 289-308 Front Matter....Pages 309-325 Mitochondrial DNA Damage in Autism....Pages 287-287 Systemic Oxidative Stress in Patients with Neurodegenerative Diseases....Pages 327-343 Front Matter....Pages 345-358 Oxidative Stress, Metabolic Syndrome and Alzheimer’s Disease....Pages 359-359 Oxidative Stress and Antioxidants in Experimental Metabolic Syndrome....Pages 361-374 Mitochondrial Dynamics Regulates Oxidative Metabolism in Leydig Tumor Cells....Pages 375-390 Cancer and Mitochondria....Pages 391-408 Tumor Immunology and Immunotherapy in Cancer Patients....Pages 409-423 Back Matter....Pages 425-442 ....Pages 443-454 The strongest point of this book titled 2Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects3, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Of particular importance is the fact that the aforementioned aspects are described in the book in a general section and in three different and important pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. The importance of these pathologies lays in the fact that, taken separately or together, they represent by far the leading cause of death in the world. Finally, all the chapters have been written by highly recognized authorities in the field of their investigations. At least to our knowledge, this is the first book with this characteristics in the field of oxidative stress