Biochemistry of Lipids, Lipoproteins and Membranes (New Comprehensive Biochemistry)

Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the last 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a reference text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002. Key Features: \* Represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific review articles and monographs. \* Allows scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances. \* Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry. Content: Edited by Page iii Copyright page Page iv Preface Page v Dennis Vance, Jean Vance List of contributors Pages vii-viii Chapter 1 Physical properties and functional roles of lipids in membranes Original Research Article Pages 1-33 Pieter R. Cullis, David B. Fenske, Michael J. Hope Chapter 2 Lipid metabolism in prokaryotes Original Research Article Pages 35-74 Charles O. Rock, Suzanne Jackowski, John E. Cronan Chapter 3 Oxidation of fatty acids Original Research Article Pages 75-99 Horst Schulz Chapter 4 Fatty acid synthesis in eukaryotes Original Research Article Pages 101-127 Lisa M. Salati, Alan G. Goodridge Chapter 5 Fatty acid desaturation and chain elongation in eukaryotes Original Research Article Pages 129-152 Harold W. Cook Chapter 6 Glycerolipid biosynthesis in eukaryotes Original Research Article Pages 153-181 Dennis E. Vance Chapter 7 Ether-linked lipids and their bioactive species: occurrence, chemistry, metabolism, regulation, and function Original Research Article Pages 183-210 Fred Snyder Chapter 8 Phospholipases Original Research Article Pages 211-236 Moseley Waite Chapter 9 Glycerolipids in signal transduction Original Research Article Pages 237-255 J. David Lambeth, Sung Ho Ryu Chapter 10 Adipose tissue and lipid metabolism Original Research Article Pages 257-281 David A. Bernlohr, Melanie A. Simpson Chapter 11 The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways Original Research Article Pages 283-308 William L. Smith, Frank A. Fitzpatrick Chapter 12 Sphringolipids: metabolism and cell signalling Original Research Article Pages 309-339 Alfred H. Merill Jr., Charles C. Sweeley Chapter 13 Isoprenoids, sterols and bile acids Original Research Article Pages 341-362 Peter A. Edwards, Roger Davis Chapter 14 Lipid metabolism in plants Original Research Article Pages 363-389 Katherine M. Schmid, John B. Ohlrogge Chapter 15 Lipid assembly into cell membranes Original Research Article Pages 391-423 Dennis R. Voelker Chapter 16 Assembly of proteins into membranes Original Research Article Pages 425-471 Reinhart A.F. Reithmeier Chapter 17 Structure, assembly and secretion of lipoproteins Original Research Article Pages 473-493 Roger A. Davis, Jean E. Vance Chapter 18 Dynamics of lipoprotein transport in the human circulatory system Original Research Article Pages 495-516 Phoebe E. Fielding, Christopher J. Fielding Chapter 19 Removal of lipoproteins from plasma Original Research Article Pages 517-541 Wolfgang J. Schneider Subject Index Pages 543-553 Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the past 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002.

Key Features:
* Represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific review articles and monographs.

* Allows scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances.

* Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry. Functional roles of lipids in membranes / William Dowhan, Mikhail Bogdanov, and Eugenia Mileykovskaya Lipid modifications of proteins / Anant K. Menon Fatty acid and phospholipid metabolism in prokaryotes / Charles O. Rock Lipid metabolism in plants / Katherine M. Schmid and John B. Ohlrogge Oxidation of fatty acids in eukaryotes / Horst Schulz Fatty acid synthesis in eukaryotes / Hei Sook Sul and Stuart Smith Fatty acid desaturation and chain elongation in mammals / Makoto Miyazaki and James M. Ntambi Phospholipid biosynthesis in eukaryotes / Dennis E. Vance and Jean E. Vance Ether-linked lipids and their bioactive species / Thomas M. McIntyre, Fred Snyder, and Gopal K. Marathe Lipid metabolism in adipose tissue / Ann V. Hertzel ... [et al.] Phospholipases / David C. Wilton The eicosanoids : cyclooxygenase, lipoxygenase, and epoxygenase pathways / William L. Smith and Robert C. Murphy Sphingolipids / Alfred H. Merrill, Jr. Cholesterol biosynthesis / Laura Liscum Metabolism and function of bile acids / Luis B. Agellon Lipid assembly into cell membranes / Dennis R. Voelker Lipoprotein structure / Ana Jonas and Michael C. Phillips Assembly and secretion of triacylglycerol-rich lipoproteins / Jean E. Vance and Khosrow Adeli Dynamics of lipoprotein transport in the circulatory system / Christopher J. Fielding and Phoebe E. Fielding Lipoprotein receptors / Wolfgang J. Schneider Lipids and atherosclerosis / Ira Tabas.