Biochemistry of Lipids, Lipoproteins and Membranes, 4th edition

Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the last 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a reference text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002. Key Features:* Represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific review articles and monographs. * Allows scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances.* Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry. Content: Preface Pages v-vi Dennis Vance, Jean Vance List of contributors Pages vii-x Other volumes in the series Pages xxvii-xxix Chapter 1 Functional roles of lipids in membranes Original Research Article Pages 1-35 William Dowhan, Mikhail Bogdanov Chapter 2 Lipid modifications of proteins Original Research Article Pages 37-54 Nikola A. Baumann, Anant K. Menon Chapter 3 Fatty acid and phospholipid metabolism in prokaryotes Original Research Article Pages 55-92 Richard J. Heath, Suzanne Jackowski, Charles O. Rock Chapter 4 Lipid metabolism in plants Original Research Article Pages 93-126 Katherine M. Schmid, John B. Ohlrogge Chapter 5 Oxidation of fatty acids in eukaryotes Original Research Article Pages 127-150 Horst Schulz Chapter 6 Fatty acid synthesis in eukaryotes Original Research Article Pages 151-179 Vangipuram S. Rangan, Stuart Smith Chapter 7 Fatty acid desaturation and chain elongation in eukaryotes Original Research Article Pages 181-204 Harold W. Cook, Christopher R. McMaster Chapter 8 Phospholipid biosynthesis in eukaryotes Original Research Article Pages 205-232 Dennis E. Vance Chapter 9 Ether-linked lipids and their bioactive species Original Research Article Pages 233-262 Fred Snyder, Ten-ching Lee, Robert L. Wykle Chapter 10 Adipose tissue and lipid metabolism Original Research Article Pages 263-289 David A. Bernlohr, Anne E. Jenkins, Assumpta A. Bennaars Chapter 11 Phospholipases Original Research Article Pages 291-314 David C. Wilton, Moseley Waite Chapter 12 Glycerolipids in signal transduction Original Research Article Pages 315-340 Linda C. McPhail Chapter 13 The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways Original Research Article Pages 341-371 William L. Smith, Robert C. Murphy Chapter 14 Sphingolipids: metabolism and cell signaling Original Research Article Pages 373-407 Alfred H. Merrill Jr., Konrad Sandhoff Chapter 15 Cholesterol biosynthesis Original Research Article Pages 409-431 Laura Liscurn Chapter 16 Metabolism and function of bile acids Original Research Article Pages 433-448 Luis B. Agellon Lipid assembly into cell membranes Original Research Article Pages 449-482 Dennis R. Welker Lipoprotein structure Original Research Article Pages 483-504 Ana Jonas Assembly and secretion of lipoproteins Original Research Article Pages 505-526 Jean E .Vance Dynamics of lipoprotein transport in the human circulatory system Original Research Article Pages 527-552 Phoebe E. Fielding, Christopher J. Fielding Lipoprotein receptors Original Research Article Pages 553-572 Wolfgang J. Schneider Chapter 22 Lipids and atherosclerosis Original Research Article Pages 573-597 Ira Tabas Subject index Pages 599-607 Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the past 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002.

Key Features:
* Represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific review articles and monographs.

* Allows scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances.

* Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry. Functional roles of lipids in membranes / William Dowhan, Mikhail Bogdanov, and Eugenia Mileykovskaya Lipid modifications of proteins / Anant K. Menon Fatty acid and phospholipid metabolism in prokaryotes / Charles O. Rock Lipid metabolism in plants / Katherine M. Schmid and John B. Ohlrogge Oxidation of fatty acids in eukaryotes / Horst Schulz Fatty acid synthesis in eukaryotes / Hei Sook Sul and Stuart Smith Fatty acid desaturation and chain elongation in mammals / Makoto Miyazaki and James M. Ntambi Phospholipid biosynthesis in eukaryotes / Dennis E. Vance and Jean E. Vance Ether-linked lipids and their bioactive species / Thomas M. McIntyre, Fred Snyder, and Gopal K. Marathe Lipid metabolism in adipose tissue / Ann V. Hertzel ... [et al.] Phospholipases / David C. Wilton The eicosanoids : cyclooxygenase, lipoxygenase, and epoxygenase pathways / William L. Smith and Robert C. Murphy Sphingolipids / Alfred H. Merrill, Jr. Cholesterol biosynthesis / Laura Liscum Metabolism and function of bile acids / Luis B. Agellon Lipid assembly into cell membranes / Dennis R. Voelker Lipoprotein structure / Ana Jonas and Michael C. Phillips Assembly and secretion of triacylglycerol-rich lipoproteins / Jean E. Vance and Khosrow Adeli Dynamics of lipoprotein transport in the circulatory system / Christopher J. Fielding and Phoebe E. Fielding Lipoprotein receptors / Wolfgang J. Schneider Lipids and atherosclerosis / Ira Tabas.