Biochemistry Of Dioxygen (biochemistry Of The Elements)

This book is written for the research biochemist who needs to know more about the particular field of dioxygen metabolism, whether this be for designing lectures for a graduate level course or for his or her own research needs. We hope researchers in a given area of dioxygen metabolism will gain knowledge of related fields of dioxygen metabolism. We have decided to use the term dioxygen to distinguish molecular oxygen from divalent oxygen in water and organic compounds, dioxygen being a simpler term than molecular oxygen. We do not intend to review the metabolism of all compounds that contain oxygen, since this would include all of biochemistry. An understanding of dioxygen chemistry is essential to the discussion of the biochemistry of dioxygen. While this statement could be made about any biochemical constituent, the chemistry of dioxygen is so unusual that interpre­ tations without detailed chemical background are futile. Prediction of dioxygen reaction products by analogy with other oxidants is impossible. The partial reduction products of dioxygen, superoxide ion and peroxides, develop naturally in the chemistry of dioxygen. It would be difficult to discuss dioxygen biochemistry without first discussing these partial reduction products. Front Matter....Pages i-xi Introduction....Pages 1-6 Ground-State Dioxygen....Pages 7-20 Singlet Dioxygen....Pages 21-43 Superoxide Ion....Pages 45-73 Dialkyl Peroxides....Pages 75-89 Catalases and Peroxidases....Pages 91-105 Dioxygen as a Terminal Oxidant and the Formation of Dioxygen....Pages 107-112 Metal-Dioxygen Complexes....Pages 113-120 Biological Iron Dioxygen Carriers....Pages 121-134 Hemocyanin: A Biological Copper Dioxygen Carrier....Pages 135-138 Oxidases....Pages 139-155 Flavin Monooxygenases....Pages 157-174 Pterin Monooxygenases....Pages 175-178 Copper Hydroxylases....Pages 179-183 Cytochrome P-450....Pages 185-197 Other Iron Monooxygenases....Pages 199-202 Ribulose Biphosphate Oxygenase....Pages 203-209 Dioxygenases....Pages 211-246 Bioluminescenc....Pages 247-254 Dioxygen Toxicity....Pages 255-266 Further Chemistry of Singlet Dioxygen....Pages 267-283 Back Matter....Pages 285-287