Biochemistry of Cell Membranes: A Compendium of Selected Topics (Molecular and Cell Biology Updates)

This book consists of a series of reviews on selected topics within the rapidly and vastly expanding field of membrane biology. Its aim is to highlight the most significant and important advances that have been made in recent years in understanding the structure, dynamics and functions of cell membranes. Areas covered in this monograph include: • Signal Transduction • Membrane Traffic: Protein and Lipids • Bioenergetics: Energy Transfer and Membrane Transport • Cellular Ion Homeostasis • Growth Factors and Adhesion Molecules • Structural Analysis of Membrane Proteins • Membranes and Disease. Biochemistry of Cell Membranes should serve as a benchmark for indicating the most important lines for future research in these areas. Front Matter....Pages i-x The role of p21ras in receptor tyrosine kinase signaling....Pages 1-14 Casein kinase-2 and cell signaling....Pages 15-27 Molecular structure of G protein-coupled P 2 purinoceptors....Pages 29-39 RAS proteins and control of the cell cycle in Saccharomyces cerevisiae ....Pages 41-53 Protein import into mitochondria....Pages 55-74 Translocation of bacterial protein toxins across membranes....Pages 75-93 Non-clathrin coat proteins in biosynthetic vesicular protein transport....Pages 95-109 Role of the GTP/GDP switch for the function of rab5 in endocytosis....Pages 111-117 Regulation of autophagy....Pages 119-135 Glycosphingolipids and sphingolipid activator proteins: Cell biology, biochemistry and molecular genetics....Pages 137-149 On the mechanism of proton pumps in respiratory chains....Pages 151-166 Energetics and formation of ATP synthase: Allosteric, chemiosmotic and biosynthetic control of αβ and αβγ core....Pages 167-178 Mitochondrial ATP synthase: Progress toward understanding the relationship between its unique structure and its biological function....Pages 179-189 Structure-function relationships in the mitochondrial carrier family....Pages 191-219 Metabolic conversions of NAD + and cyclic ADP ribose at the outer surface of human red blood cells....Pages 221-229 Mg 2+ Homeostasis in cardiac ventricular myocytes....Pages 231-244 Signal transduction by growth factor receptors....Pages 245-258 Cell surface associated mucins: Structure and effects on cell adhesion....Pages 259-271 Role of β 1 integrin cytoplasmic domain in signaling and cell adhesion....Pages 273-290 Structural analysis of membrane proteins....Pages 291-296 Helix-helix interactions inside membranes....Pages 297-310 Annexin V: Structure-function analysis of a voltage-gated, calcium-selective ion channel....Pages 311-325 Structure and function of the membrane channel porin....Pages 327-338 Oxygen damage and mutations in mitochondrial DNA associated with aging and degenerative diseases....Pages 339-361 Back Matter....Pages 363-365