Biochemistry and cell biology of ageing. Part II, Clinical science

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact. Front Matter ....Pages i-x Poor Early Growth and Age-Associated Disease (Jane L. Tarry-Adkins, Susan E. Ozanne)....Pages 1-19 The Immune System and Its Dysregulation with Aging (Ludmila Müller, Svetlana Di Benedetto, Graham Pawelec)....Pages 21-43 Pulmonary Diseases and Ageing (Peter J. Barnes)....Pages 45-74 Neurodegenerative Diseases and Ageing (Lauren Walker, Kirsty E. McAleese, Daniel Erskine, Johannes Attems)....Pages 75-106 Ageing and Cognition (Sydney M. A. Juan, Paul A. Adlard)....Pages 107-122 Ageing and Osteoarthritis (Pradeep Kumar Sacitharan)....Pages 123-159 Down Syndrome, Ageing and Epigenetics (Noémie Gensous, Claudio Franceschi, Stefano Salvioli, Paolo Garagnani, Maria Giulia Bacalini)....Pages 161-193 The Vestibular System and Ageing (Sonja Brosel, Michael Strupp)....Pages 195-225 Signal Transduction, Ageing and Disease (Lei Zhang, Matthew J. Yousefzadeh, Yousin Suh, Laura J. Niedernhofer, Paul D. Robbins)....Pages 227-247 Skin Changes During Ageing (Frédéric Bonté, Dorothée Girard, Jean-Christophe Archambault, Alexis Desmoulière)....Pages 249-280 Connective Tissue and Age-Related Diseases (Carolyn Ann Sarbacher, Jaroslava T. Halper)....Pages 281-310 Potential Cellular and Biochemical Mechanisms of Exercise and Physical Activity on the Ageing Process (Mark Ross, Hannah Lithgow, Lawrence Hayes, Geraint Florida-James)....Pages 311-338 Health Benefits of Anti-aging Drugs (Veronika Piskovatska, Olha Strilbytska, Alexander Koliada, Alexander Vaiserman, Oleh Lushchak)....Pages 339-392 Visual Defects and Ageing (Sergio Claudio Saccà, Carlo Alberto Cutolo, Tommaso Rossi)....Pages 393-434 Hutchinson-Gilford Progeria Syndrome: Challenges at Bench and Bedside (Ray Kreienkamp, Susana Gonzalo)....Pages 435-451 Osteoporosis and the Ageing Skeleton (Terry J. Aspray, Tom R. Hill)....Pages 453-476 Neurovascular Ageing and Age-Related Diseases (Raj N. Kalaria, Yoshiki Hase)....Pages 477-499 In recent years, volumes of the long-established Springer Subcellular Biochemistry series have shown great diversity of content, thus interesting biochemical topics, enthusiastically edited in all cases, have been readily accommodated. This new volume of the Subcellular Biochemistry series, Biochemistry and Cell Biology of Ageing: Part II, offers a broad overview of many different Clinical Science aspects of Ageing. The 17 chapters included in the book, contributed by knowledgeable authors, review many important topics at an advanced level. Whilst it has proved impossible to include all relevant topics, there is much present that will be of value to the reader. The book contains chapters on: "Poor Early Growth and Age-associated Disease; The Immune System and its Dysregulation with Ageing; Pulmonary Diseases and Ageing; Neurodegenerative Diseases and Ageing; Ageing and Cognition; Ageing and Osteoarthritis; Down Syndrome, Ageing and Epigenetics; The Vestibular System and Ageing; Signal Transduction, Ageing and Disease; Skin Changes During Ageing; Connective Tissue and Age-related Diseases ; Potential Cellular and Biochemical Mechanisms of Exercise and Physical Activity on the Ageing Process; Health Benefits of Anti-ageing Drugs; Visual Defects and Ageing; Hutchinson-Gilford Progeria Syndrome: Challenges at Bench and Bedside; Osteoporosis and the Ageing Skeleton; Neurovascular Ageing and Age-related Diseases" The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers, clinicians and academics in the field of Ageing. An earlier companion volume of the Subcellular Biochemistry series - Biochemistry and Cell Biology of Ageing: Part I (Volume 90) - covering the Biomedical Science aspects of ageing, has also been recently published