Biochemical Roles of Eukaryotic Cell Surface Macromolecules: 2011 ISCSM Proceedings (Advances in Experimental Medicine and Biology Book 749)

Cell surface molecules are critically important in regulating cell structure and function. Recent advances on the functional role of cell surface molecules, particularly glycoconjugates are presented in this book. Comprising of 22 chapters from the 2011 International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules, it covers topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell–matrix interaction. Front Matter....Pages i-xvi Glycomics: An Overview of the Complex Glycocode....Pages 1-13 Structural Glycomic Approaches to Molecular Recognition Events on Cell Surfaces....Pages 15-32 ISCSM2011 Chondroitin Sulfate E-type Structure at Tumor Cell Surface Is Involved in Experimental Metastasis....Pages 33-45 Chondroitin Sulfate-Specific Novel Hydrolase in Human....Pages 47-56 Identification of Endothelial Cell Surface Carbohydrate-Binding Receptors by Carbohydrate Ligand Mimicry Peptides....Pages 57-66 Lysosomal Enzyme Sorting Receptors—Where Did They First Appear in the Animal Kingdom?....Pages 67-82 Endoplasmic Reticulum-Targeted Bcl-2 Inhibitable Mitochondrial Fragmentation Initiates ER Stress-Induced Cell Death....Pages 83-95 Interactions Between Caveolin-1 and Sphingolipids, and Their Functional Relevance....Pages 97-115 Cell Membrane Repair Pathway Involves Sensing of Dynamics of Caveolae and Caspase-1....Pages 117-129 Angiogenic Response of Endothelial Cells to Fibronectin....Pages 131-151 Lactosylceramide Synthase as a Therapeutic Target to Mitigate Multiple Human Diseases in Animal Models....Pages 153-169 Advanced FRET Methodologies: Protein–Lipid Selectivity Detection and Quantification....Pages 171-185 Mechanism of GPCR-Directed Autoantibodies in Diseases....Pages 187-199 Role of Membrane Cholesterol in Leishmanial Infection....Pages 201-213 How Intact Is the Basement Membrane? Role of MMPs....Pages 215-232 Apoptosis of Breast Cancer Cells: Modulation of Genes for Glycoconjugate Biosynthesis and Targeted Drug Delivery....Pages 233-255 Altered Expression of Sialidases in Human Cancer....Pages 257-267 Poly-ADP-Ribosylation of Vascular Endothelial Growth Factor and Its Implications on Angiogenesis....Pages 269-278 Sphingolipid-Binding Domain in the Serotonin 1A Receptor....Pages 279-293 Withanolide D, Carrying the Baton of Indian Rasayana Herb as a Lead Candidate of Antileukemic Agent in Modern Medicine....Pages 295-312 Engineered Glucose to Generate a Spectroscopic Probe for Studying Carbohydrate Biology....Pages 313-327 Changes in Sialic Acid Content of Jelly Coat in Pesticide-Exposed Frog Eggs and Their Influence on Fertilization....Pages 329-336 Back Matter....Pages 337-340 The 2011 international symposium on the "Biochemical Role of Eukaryotic Cell surface Macromolecules" (Trivandrum, India - Jan 2011) covered topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell-matrix interaction. Contributions from this meeting are presented this volume, providing an in-depth analysis of data on cell surface macromolecules in cellular function and their alteration associated with pathological conditions. All contributions are either comprehensive critical reviews or original research papers and cover the most relevant and recent topics related to functional role of cell surface molecules Consists of critical reviews and original research papers from the 2014 International Symposium on the "Biochemical Role of Eukaryotic Cell Surface Macromolecules". Topics covered include: · neurochemical and biochemical analysis of cell surface glycoconjugates · membrane skeletal organization · GPCRs and other receptors · biophysical approaches to study membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms involved in cell-cell and cell-matrix interaction · glycans in infectious and neurological diseases · cancer and glycosyltransferases as drug targets.