Biochemical mechanisms of paraquat toxicity : proceedings of the First Iowa Symposium on Toxic Mechanisms, June 28-29, 1976, Iowa City, Iowa

Biochemical Mechanisms of Paraquat Toxicity presents the proceedings of the First Iowa Symposium on Toxic Mechanisms that was held from June 28-29, 1976. The symposium brought together a diverse group of investigators consisting of chemists, pharmacologists, pathologists, biochemists, and toxicologists from the United States, Canada, and Europe who have been interested in the mechanism of paraquat toxicity. The book includes papers on the following topics: the general features of toxic lung injury and observations with paraquat and diquat; electron transfer reactions of paraquat; the pathological effects of paraquat on the human lung; and the importance of oxygen and pulmonary alveolar surfactant in lung injury by paraquat. Other papers deal with the effects of paraquat on kidney and liver function in experimental animals; lipid peroxidation as a proposed mechanism for paraquat toxicity; pulmonary fibrosis as a consequence of paraquat toxicity; biochemical changes in lungs exposed to paraquat; effects of selenium deficiency on paraquat toxicity; and treatment for paraquat poisoning. Content: Academic Press Rapid Manuscript Reproduction , Page ii Front Matter , Page iii Copyright , Page iv Contributors and Participants , Pages vii-viii Preface , Page ix PRIMARY EVENTS IN LUNG FOLLOWING EXPOSURE TO TOXIC CHEMICALS , Pages 1-20 , HANSPETER WITSCHI, KEI-ICHI HIRAI, MICHEL G. COTÉ ELECTRON TRANSFER REACTIONS OF PARAQUAT , Pages 21-38 , ANTHONY LEDWITH THE PATHOLOGY OF THE LUNG IN PARAQUAT POISONING , Pages 39-55 , DONALD HEATH, PAUL SMITH IMPORTANCE OF OXYGEN AND OF PULMONARY ALVEOLAR SURFACTANT IN LUNG INJURY BY PARAQUAT , Pages 57-69 , H. KENNETH FISHER THE RELEVANCE OF PARAQUAT ACCUMULATION BY TISSUES , Pages 71-91 , MICHAEL S. ROSE, LEWIS L. SMITH IN VITRO AND IN VIVO EFFECTS OF PARAQUAT ON RAT LIVER MITOCHONDRIA , Pages 93-115 , KRYSTYNA KOPACZYK-LOCKE PARAQUAT INDUCED FUNCTIONAL CHANGES IN KIDNEY AND LIVER , Pages 117-136 , JAMES E. GIBSON, STUART Z. CAGEN ON THE MECHANISM OF THE POTENTIATION BY BETA ADRENERGIC AGONISTS OF PARAQUAT TOXICITY IN RATS AND MICE , Pages 137-156 , HARRIET M. MALING, WILFORD SAUL, MARTHA A. WILLIAMS, ELISE A.B. BROWN, JAMES R. GILLETTE LIPID PEROXIDATION AS A PROPOSED MECHANISM FOR PARAQUAT TOXICITY , Pages 157-174 , JAMES S. BUS, STEVEN D. AUST, JAMES E. GIBSON PULMONARY FIBROSIS AND PARAQUAT TOXICITY , Pages 175-186 , ANNE P. AUTOR, SUSAN L. SCHMITT BIOCHEMICAL CHANGES IN LUNGS EXPOSED TO PARAQUAT , Pages 187-199 , LEWIS L. SMITH, MICHAEL S. ROSE PARAQUAT TOXICITY: EFFECTS OF SELENIUM DEFICIENCY AND ANTI-INFLAMMATORY DRUG PRETREATMENTS , Pages 201-211 , CARROLL E. CROSS, KRISHNA A. REDDY, GLENN K. HASEGAWA, MAGGIE M. CHIU, WALTER S. TYLER, STANLEY T. OMAYE AN EFFECTIVE TREATMENT FOR PARAQUAT POISONING , Pages 213-230 , RICHARD D. CAVALLI, KENNETH FLETCHER Optical Spectra , Pages 231,233-234 Index , Pages 235-240 Primary Events In Lung Following Exposure To Toxic Chemicals / Hanspeter Witschi, Kei-ichi Hirai, And Michel G. Coté -- Electron Transfer Reactions Of Paraquat / Anthony Ledwith -- The Pathology Of The Lung In Paraquat Poisoning / Donald Heath And Paul Smith -- Importance Of Oxygen And Of Pulmonary Alveolar Surfactant In Lung Injury By Paraquat / H. Kenneth Fisher -- The Relevance Of Paraquat Accumulation In Tissues / Michael S. Rose And Lewis L. Smith -- In Vitro And In Vivo Effects Of Paraquat On Rat Liver Mitochondria / Krystina Kopaczyk-locke -- Paraquat Induced Functional Changes In Kidney And Liver / James E. Gibson And Stuart Z. Cagen -- On The Mechanism Of The Potentiation By Beta Adrenergic Agonist Of Paraquat Toxicity In Rats And Mice / Harriet M. Maling ... [et Al.] -- Lipid Peroxidation As A Proposed Mechanism For Paraquat Toxicity / James S. Bus, Steven D. Aust, And James E. Gibson -- Pulmonary Fibrosis And Paraquat Toxicity / Anne P. Autor And Susan L. Smith -- Biochemical Changes In Lungs Exposed To Paraquat / Lewis L. Smith And Michael S. Rose -- Paraquat Toxicity: Effects Of Selenium Deficiency And Anti-inflammatory Drug Pretreatments / Carroll E. Cross ... [et Al.] -- An Effective Treatment For Paraquat Poisoning / Richard D. Cavalli And Kenneth Fletcher. Edited By Anne Pomeroy Autor. Sponsored By The National Institute Of General Medical Sciences, Pharmacology Toxicology Program, Standard Oil Company (chevron Environmental Health Center), And The National Institute Of Environmental Health Sciences. Includes Bibliographical References And Index.