Biochemical Basis and Therapeutic Implications of Angiogenesis (Advances in Biochemistry in Health and Disease Book 6)

Angiogenesis is a highly complex phenomenon where new blood vessels are formed for the supply of oxygen and nutrients in different organs of the body. It plays a critical role in both physiological processes such as growth and development as well as pathological processes including cancer and different types of tumors. Angiogenesis is also essential for the regeneration and survival of cells in several disease conditions such as ischemic heart disease (myocardial infarction), atherosclerosis, brain injury (stroke) and diabetes. Since the mechanisms of angiogenesis are organ specific and differ among various diseases, it is proposed to devote one section of this book to the development of angiogenesis in some selected diseases such as cancer, ischemic heart disease, atherosclerosis, diabetes and stroke. It is pointed out that extensive research work in this regard has been carried out in the area of cancer and heart disease, whereas relatively less attention has been paid to studying angiogenesis in other disease conditions. Front Matter....Pages i-xviii Front Matter....Pages 1-1 Endothelial Growth Factor Receptors in Angiogenesis....Pages 3-22 Role of Transforming Growth Factor Beta in Angiogenesis....Pages 23-45 Role of Cytokines in Angiogenesis: Turning It On and Off....Pages 47-61 Neuropeptides and Angiogenesis....Pages 63-77 Role of Integrins in Angiogenesis....Pages 79-91 Regulation of Angiogenesis by Hypoxia-Inducible Factors....Pages 93-106 Role of Mast Cells in Angiogenesis....Pages 107-121 Vascular Stem Cells in Regulation of Angiogenesis....Pages 123-138 Toll-Like Receptor-Linked Signal Transduction in Angiogenesis....Pages 139-157 Role of Sex Steroids in Angiogenesis....Pages 159-180 Biochemical Mechanisms of Exercise-Induced Angiogenesis....Pages 181-206 Front Matter....Pages 207-207 Angiogenesis in Atherosclerosis: An Overview....Pages 209-224 Role of Serotonin in Angiogenesis in Diabetes....Pages 225-238 Brain Angiogenesis After Stroke....Pages 239-260 Angiogenesis in Myocardial Ischemia....Pages 261-283 Adipose Tissue-Derived Mesenchymal Stem Cell and Angiogenesis in Ischemic Heart Disease....Pages 285-311 Trials of Angiogenesis Therapy in Patients with Ischemic Heart Disease....Pages 313-334 Angiogenesis in Cancer....Pages 335-356 Potential Mechanisms Linking Oxidized LDL to Susceptibility to Cancer....Pages 357-379 Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small-Cell Lung Cancer Tumor Behavior: Implications in Risk Assessment and Clinical Outcome....Pages 381-403 Front Matter....Pages 405-405 Angiogenic and Arteriogenic Factors: Their Role in the Treatment of Cancer and Arterial Regeneration....Pages 407-412 Physiological Roles and Therapeutic Implications of Hepatocyte Growth Factor for Angiogenesis....Pages 413-443 Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis....Pages 445-458 Microarray, MicroRNA, and Angiogenesis....Pages 459-477 MicroRNA and Cardiovascular Disorders with a Focus on Angiogenesis....Pages 479-497 Overview of Angiogenesis Inhibitors from Natural Sources....Pages 499-520 Back Matter....Pages 521-532 Angiogenesis plays a key role in human physiology and pathophysiology. While necessary for tissue growth and development, uncontrolled angiogenesis plays a role in the progression of certain tumors as well as atherosclerosis. Lack of angiogenesis may be the basis of myocardial ischemia and stroke. Knowledge on the mechanisms of angiogenesis is growing very rapidly, and may lead to important drugs for therapy of a variety of clinical disorders. Experts from around the world have contributed a vast array of data on different aspects of angiogenesis in this volume edited by Professors Mehta and Dhalla. This information will be of immense help to basic scientists, clinicians and those involved in drug development. Leading authorities on the biochemistry of this complex physiological process explain its critical role in human growth and development as well as the pathogenesis of cancer, heart disease, and other morbidities. The book fully updates the current literature.