Biochemical and clinical aspects of oxygen : proceedings of a symposium held on the Pingree Park Campus, Colorado State University, September 24-29, 1978

Biochemical and Clinical Aspects of Oxygen contains the proceedings of a symposium held on the Pingree Park Campus of Colorado State University on September 24-29, 1978. Contributors discuss the biochemical and clinical aspects of oxygen, focusing on reactions and areas relating to heme, flavin, copper and nonheme iron proteins, organ transplants, carbon monoxide formation and detoxification, oxidant drugs and pollutants, oxygen toxicity, enzyme inactivation, lipid peroxidation, membrane destruction, antioxidants, cataractogenesis, mutagen and carcinogen formation, malaria and trypanosome parasites, and inflammation. This volume is organized into 51 chapters and begins with a discussion of bonding and reactions of dioxygen bound to hemeproteins, along with the pathophysiology of hemolysis due to unstable hemoglobins. The focus then turns to the reactivity and function of leghemoglobin, reduction of oxygen and five redox forms of horseradish peroxidase, and acid-base catalysis and hydrogen bonding in reactions mediated by peroxidases. The reader is methodically introduced to the ligands of cytochrome P-450 and their role in the activation of dioxygen, oxygen and catabolite regulation of hemoprotein biosynthesis in yeast, and factors controlling hemoprotein reactivity. A chapter describing the spectroscopic mapping of oxygen supply and demand in the heart concludes the book. This book will be of interest to biochemists, biophysicists, physicians, toxicologists, immunologists, physiologists, parasitologists, radiologists, and environmentalists. Content: Front Matter , Page iii Copyright , Page iv LIST OF CONTRIBUTORS , Pages xi-xvii PREFACE , Pages xix-xx BONDING AND REACTIONS OF DIOXYGEN BOUND TO HEMEPROTEINS , Pages 1-18 , Winslow S. Caughey, Miles G. Choc, Robert A. Houtchens PATHOPHYSIOLOGY OF HEMOLYSIS DUE TO UNSTABLE HEMOGLOBINS , Pages 19-25 , Samuel Charache FORMATION OF METHEMOGLOBINS AND PEROXIDE FROM THE REACTION OF OXYHEMOGLOBINS WITH REDUCING AGENTS , Pages 27-34 , Shosuke Kawanishi, Winslow S. Caughey MYOGLOBIN IN ISOLATED ADULT HEART CELLS , Pages 35-51 , Beatrice A. Wittenberg REACTIVITY AND FUNCTION OF LEGHEMOGLOBIN , Pages 53-68 , Jonathan B. Wittenberg SUPEROXIDE AS A PARTICIPANT IN THE CHEMISTRY OF OXYHEMOGLOBIN , Pages 69-86 , W.J. Wallace, W.S. Caughey THEORETICAL STUDIES OF THE BONDING OF O 2 TO HEMOGLOBIN; IMPLICATIONS FOR COOPERATIVITY , Pages 87-123 , William A. Goddard III, Barry D. Olafson POLARIZED SINGLE CRYSTAL ABSORPTION SPECTRA OF THE REACTION PRODUCTS OF SPERM WHALE MYOGLOBIN WITH O 2 , OH − , AND H 2 O 2 , Pages 125-142 , Antonie K. Churg, Harold A. Glick, John A. Zelano, Marvin W. Makinen A COMMENT ON THE ELECTRONIC STRUCTURE OF THE Fe-O 2 GROUP IN OXYHEME , Pages 143-155 , Marvin W. Makinen REDUCTION OF OXYGEN AND FIVE REDOX FORMS OF HORSERADISH PEROXIDASE , Pages 157-165 , Yukiko Hayashi, Isao Yamazaki HYDROGEN PEROXIDE, OXYGEN, SUPEROXIDE ANION, SINGLET OXYGEN AND PEROXIDASE , Pages 167-176 , H.B. Dunford THE HEME-ENVIRONMENT OF IRON AND MANGANESE HORSERADISH PEROXIDASE AS STUDIED BY WATER PROTON RELAXATION AND OXYGEN-17 SUPERHYPERFINE INTERACTION , Pages 177-193 , Raj K. Gupta, Albert S. Mildvan, Gregory R. Schonbaum ACID-BASE CATALYSIS AND HYDROGEN BONDING IN REACTIONS MEDIATED BY PEROXIDASES , Pages 195-211 , G.R. Schonbaum, R.A. Houtchens, W.S. Caughey FATTY ACID OXYGENASE KINETICS AND THE ROLE OF PEROXIDES 3. HYDROPEROXIDES IN INFLAMMATION: CELLULAR AND MOLECULAR RECRUITMENT, , Pages 213-226 , William E.M. Lands, Martin E. Hemler THE LIGANDS OF CYTOCHROME P-450: IDENTIFICATION AND ROLE IN THE ACTIVATION OF DIOXYGEN , Pages 227-262 , Julian A. Peterson MECHANISM OF ACTION OF CYTOCHROME P-450 STUDIED WITH PERACIDS AS OXYGEN DONORS , Pages 263-275 , Robert C. Blake II, Minor J. Coon OXO- AND PEROXO-TRANSITION METAL SPECIES IN CHEMICAL AND BIOCHEMICAL OXIDATIONS. POSSIBLE MODELS FOR THE OXYGEN ACTIVATION AND TRANSFER CATALYZED BY CYTOCHROME P-450 , Pages 277-309 , John T. Groves, Gary A. McClusky STUDIES ON OXYGEN REDUCTION BY HEART CYTOCHROME c OXIDASE , Pages 311-322 , Shinya Yoshikawa, Winslow S. Caughey IS COMPOUND C ANOTHER CARBON MONOXIDE COMPLEX OF CYTOCHROME c OXIDASE? , Pages 323-335 , Peter Nichollss ELECTRON TRANSFER FROM CYTOCHROME c TO DIOXYGEN BY CYTOCHROME c OXIDASE , Pages 337-354 , Charles R. Hartzell, Nancy A. Schroedl ROLE OF OXYGEN AND CYTOCHROME c OXIDASE IN THE DETOXIFICATION OF CO BY OXIDATION TO CO 2 , Pages 355-361 , Lawrence J. Young, Miles G. Choc, Winslow S. Caughey SOME PHYSICAL PROPERTIES OF HYDROXYINDOLE OXIDASE , Pages 363-374 , J. Peisach, L. Kampa, A. Rispin, W.E. Blumberg REDUCTION OF CYTOCHROME o , Pages 375-393 , Victoria Gonzales-Prevatt, Dale A. Webster SOME RECENT STUDIES ON THE ABNORMAL PATHWAYS OF HEME DEGRADATION NOT INVOLVING PRODUCTION OF CARBON MONOXIDE , Pages 395-404 , F. De Matteis, L. Cantoni, A.H. Gibbs CHARACTERIZATION OF THE STEADY STATE OXYGEN KINETICS OF TERMINAL OXIDASES IN TRYPANOSOMA RHODESIENSE , Pages 405-420 , George C. Hill, Hans Degn OXYGEN AND CATABOLITE REGULATION OF HEMOPROTEIN BIOSYNTHESIS IN YEAST , Pages 421-435 , James R. Mattoon, William E. Lancashire, Hildagarde K. Sanders, Elvira Carvajal, Dulce R. Malamud, Gloria R.C. Braz, Anita D. Panek REDUCTION OF OXYGEN BY CYTOCHROME OXIDASE MODELS , Pages 437-454 , C.K. Chang FACTORS CONTROLLING HEMOPROTEIN REACTIVITY AS STUDIED WITH SYNTHETIC MODEL COMPOUNDS , Pages 455-476 , T.G. Traylor, A. Berzinis, D. Campbell, J. Cannon, W. Lee, D. McKinnon, T. Mincey, D.K. White ON THE MECHANISM OF FLAVIN-CATALYSED HYDROXYLATION REACTIONS , Pages 477-490 , Vincent Massey ON THE CHEMISTRY OF FLAVIN DEPENDENT OXYGEN ACTIVATION , Pages 491-511 , P. Hemmerich, A. Wessiak SINGLET MOLECULAR OXYGEN CHEMISTRY AND IMPLICATIONS FOR FLAVIN-COFACTOR HYDROXYLATIONS , Pages 513-555 , William A. Goddard III, Lawrence B. Harding OXYGEN AND HYDROGEN PEROXIDE PROMOTED INTERCONVERSION OF IRON(II) AND IRON(III) IN HEMERYTHRIN , Pages 557-571 , Z. Bradić, P.C. Harrington, R.G. Wilkins ISOLATION AND PROPERTIES OF PROTOCATECHUATE DIOXYGENASE FROM PSEUDOMONAS PUTIDA , Pages 573-587 , D. Ballou, C. Bull THE QUATERNARY STRUCTURE OF MUSHROOM TYROSINASE AND THE SUBUNIT COMPOSITION OF FOUR ACTIVE SPECIES OF THE ENZYME , Pages 589-602 , Steven Gutterldge, Howard S. Mason DETECTION OF SINGLET OXYGEN IN COMPLEX SYSTEMS: A CRITIQUE , Pages 603-626 , Christopher S. Foote GENERATION AND SUBSEQUENT QUENCHING OF SINGLET OXYGEN IN THE REACTION OF POTASSIUM SUPEROXIDE WITH IODINE , Pages 627-634 , Frank E. Scully Jr. THE ROLE OF SUPEROXIDE IN THE INDUCTION OF SUPEROXIDE DISMUTASE AND OXYGEN TOXICITY , Pages 635-658 , J.A. Fee, A.C. Lees, P.L. Bloch, F.C. Neidhardt THE CHEMICAL REACTIVITY OF SUPEROXIDE ANION IN APROTIC VERSUS PROTIC MEDIA: A REVIEW , Pages 659-677 , Joan S. Valentine MEASUREMENT OF AND PROTECTION FROM IN VIVO LIPID PEROXIDATION , Pages 679-698 , Al L. Tappel LIPID PEROXIDATION IN MODEL AND NATURAL MEMBRANES , Pages 699-708 , J.F. Mead, A. Sevanian, R.A. Stein, G.-S. Wu GENERATION OF OXYGEN METABOLITES BY PHAGOCYTIC CELLS: STUDIES WITH A SUBCELLULAR FRACTION OF HUMAN NEUTROPHILS , Pages 709-724 , Linda C. McPhail, Daniel R. Ambruso, Michael J. Pabst, Richard B. Johnston Jr. THE EFFECT OF TEMPERATURE ON CHEMILUMINESCENCE BY POLYMORPHONUCLEAR LEUKOCYTES IN VITRO , Pages 725-736 , John E. Repine, John R. Hoidal, Gregory D. Beall, Fred L. Rasp Jr., Dennis P. Clifford, John W. Eaton, Scott Davies, C.C. Clawson, James G. White, Richard B. Fox ORGANISMAL, TISSUE AND ENZYMATIC LEVEL METABOLIC RESPONSES TO AN OXYGEN-RICH ENVIRONMENT , Pages 737-754 , John Patrick Jordan, Robert R. Gorman SPECIFIC ENZYMATIC SITES AND CELLULAR MECHANISMS OF OXYGEN TOXICITY , Pages 755-766 , Olen R. Brown EFFECT OF OXYGEN AND RELATED RADICALS ON RAT PULMONARY CELLS , Pages 767-783 , Anne P. Autor, Arthur W. Fox, Jeffrey B. Stevens MECHANISM OF CATARACTOGENESIS INDUCED BY 3-AMINO-1H-1,2, 4-TRIAZOLE I: MORPHOLOGY AND HISTOPATHOLOGY OF CATARACT AND THE ROLE OF CATALASE IN THE REGULATION OF H 2 O 2 IN THE EYE , Pages 785-796 , Kailash C. Bhuyan, Durga K. Bhuyan MECHANISM OF CATARACTOGENESIS INDUCED BY 3-AMINO-1H-1,2,4-TRIAZOLE II: SUPEROXIDE DISMUTASE OF THE EYE AND ITS ROLE IN PROTECTING THE OCULAR LENS FROM OXIDATIVE DAMAGE BY ENDOGENOUS , H 2 O 2 AND/OR OH , Pages 797-809 , Durga K. Bhuyan, Kailash C. Bhuyan THE ROLE OF OXYGEN IN THE RADIATION BIOLOGY OF TUMORS , Pages 811-823 , Helen B. Stone MALARIA INFECTION AND HOST CELL OXIDANT DAMAGE , Pages 825-837 , John W. Eaton, James R. Eckman THE ENHANCED SURVIVAL OF MOUSE THYROID ALLOGRAFTS AFTER TREATMENT WITH HYPERBARIC OXYGEN , Pages 839-844 , David W. Talmage, Gladys Dart SPECTROSCOPIC MAPPING OF OXYGEN SUPPLY-DEMAND IN HEART , Pages 845-857 , Clyde H. Barlow, Britton Chance, Wesley Harden III, Michael B. Simson, Alden H. Harken INDEX , Pages 859-866