Biocatalysis (Special Edition of "Monatshefte Fur Chemie/Chemical Monthly", Vol 131, No 6, 2000)

The book contains in its first part reviews on modelling of enzyme properties in organic solvents, lipase-catalysed synthesis of carboxylic amides, chemoenzymatic synthesis of lipidated peptides and chemoenzymatic transformations in nucleoside chemistry. In the second part contributions on recent developments in biocatalysis are given: lipase and esterase catalysed resolutions, investigations on regio- and stereoselective biocatalytic acylations in steroid side-chains and of substrate- and stereospecificity of Penicillin G amidases, deracemisation for amino acid synthesis, biocatalytic hydrolysis of nitriles, enzymatic and microbial hydroxylation of dienes and alpha-methyl esters, enantioselective sulphoxidations by peroxidases. Front Matter....Pages I-VIII Modelling of Enzyme Properties in Organic Solvents....Pages 1-21 Lipase-Catalyzed Synthesis of Carboxylic....Pages 23-43 Chemoenzymatic Synthesis of Lipidated....Pages 45-58 Chemoenzymatic Transformations in Nucleoside Chemistry....Pages 59-90 Lipase-Catalyzed Regio-and Stereoselective Acylation of Hydroxy Groups in Steroid Side Chains....Pages 91-96 Comparative Study of Substrate-and Stereospecificity of Penicillin G amidases from Different Sources and Hybrid Isoenzymes....Pages 97-106 Lipase-Catalyzed Resolution of Ibuprofen....Pages 107-112 Novel Carboxyl Esterase Preparations for the Resolution of Linalyl Acetate....Pages 113-118 Microbial and Enzymatic Synthesis of Optically Pure D- and L-3-Trimethylsilyl-alanine by Deracemization of D,L-5-Trimethylsilyl-methyl-hydantoin....Pages 119-127 Immobilization of Rhodococcus AJ270 and Use of Entrapped Biocatalyst for the Production of Acrylic Acid....Pages 129-140 Beauveria bassiana ATCC 7159 Contains an L-Specific a-Amino Acid Benzamidase....Pages 141-146 Bacterial Biotransformation of Isopreneand Related Dienes....Pages 147-159 Enantioselective Sulfoxidations Catalyzed by Horseradish Peroxidase, ManganesePeroxidase, and Myeloperoxidase....Pages 161-169 Synthesis of Optically Active a-Methyl ß-Hydroperoxy Esters by Diastereoselective Singlet Oxygen Ene Reaction and Horseradish Peroxidase Catalyzed Kinetic Resolution....Pages 171-179 This text reviews the modelling of enzyme properties in organic solvents, lipase-catalysed synthesis of carboxylic amides, chemoenzymatic synthesis of lipidated peptides and chemoenzymatic transformations in nucleoside chemistry. It also contains contributions on recent developments. The suspension or dissolution of enzymes in non-aqueous media affords many advantages (as well as some disadvantages) over the use of proteins in aqueous solution.