Bioassay Methods in Natural Product Research and Drug Development (Proceedings of the Phytochemical Society of Europe, 43)

__Bioassay Methods in Natural Product Research and Drug Development__ contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery. Front Matter....Pages i-x Plant Biodiversity....Pages 1-9 Chemodiversity and the Biological Role of Secondary Metabolites, Some Thoughts for Selecting Plant Material for Drug Development....Pages 11-23 Evolving Strategies for the Selection, Dereplication and Prioritization of Antitumor and HIV-Inhibitory Natural Products Extracts....Pages 25-35 Screening Methods for Detection and Evaluation of Biological Activities of Plant Preparations....Pages 37-52 The use of Receptor Binding, a Very Specific, High Capacity Screening Method, in the Identification of Biologically Active Components from Natural Sources....Pages 53-65 Biological and Chemical Evaluation of Plant Extracts and Subsequent Isolation Strategy....Pages 67-80 Natural Products with Antiprotozoal Activity....Pages 81-99 In-Vitro Assays for Activity-Guided Enrichment of Immunomodulatory Plant Constituents....Pages 101-111 Search for Potent Immunomodulatory Agents from Plants and Other Sources....Pages 113-118 Cyclooxygenase and 5-Lipoxygenase as Targets for Medicinal Plant Research....Pages 119-141 Natural Products in Drug Discovery and Development....Pages 143-149 QPRI’s System for Screening of Natural Products....Pages 151-157 Phytera’s Strategy for the Discovery of Novel Anti-Infective Agents from Plant Cell Cultures....Pages 159-166 Expediting Drug Development through the Use of Plants....Pages 167-181 The Future Role of Natural Products in Drug Discovery....Pages 183-193 Back Matter....Pages 194-203