Bioactive Spin Labels

Bioactive Spin Labels is a collection of contributions by leading experts on nitroxyl radicals and their application in biomedicine. These compounds are used as side specific contrast agents for in-vivo EPR techniques. Their potential as drugs is investigated. Bioactive Spin Labels is a must for researchers in bioorganic chemistry, pharmacology and biomedicine. Front Matter....Pages I-X Spin-Labeled Medicines: Enzymes, Biomembranes and Possible Pharmaceuticals. An Overview....Pages 1-21 Nitroxyl Radicals and Non-Radical Reactions of Free Radicals....Pages 23-82 Triacetonamine in the Chemistry of Nitroxyl Radicals....Pages 83-118 Catalysis of Redox Processes by Nitroxyl Radicals....Pages 119-140 Biomembrane Reactions of Nitroxyl Radicals....Pages 141-179 Relaxation Processes Involving Nitroxyl Radicals in Molecular Biology....Pages 181-200 Investigations on Spin Exchange in Nitroxyls by the Method of Continuous Saturation of EPR Spectra....Pages 201-214 Spin Exchange Components in Nitroxyl Biradicals EPR Spectra....Pages 215-225 Investigation of Spin Labels and Probes by Millimeter Band EPR....Pages 227-278 Analysis of Spin Label Slow Motions Based on Simulating 2-MM Band EPR Spectra....Pages 279-296 Synthesis and Properties of Spin-Labeled Phospholipids....Pages 297-315 Spin-Labeled Phospholipids for Protein—Lipid Interactions....Pages 317-336 Spin-Labeled Organophosphorus Compounds....Pages 337-353 Spin-Labeled Close Analogs of Sugars and Nucleosides....Pages 355-387 Spin-Labeling Study of the Structure and Function of Leucine Aminopeptidase....Pages 389-403 Photoaffinity Spin Labeling....Pages 405-427 The Toxicity of Aminoxyl Radicals....Pages 429-438 Nitroxyl Radicals for Cancer Chemotherapy....Pages 439-460 Spin Labeling Study of Platelet Plasma Membrane and Nitroxyl Aggregation Inhibitors....Pages 461-489 Anti-Ischemic Effect of 1-Hydroxy Derivatives of Nitroxyl Bioantioxidants....Pages 491-507 Spin Probes for the Study of Intact and Cancer Cell Membranes....Pages 509-526 Pharmacokinetics of Nitroxyl Radicals....Pages 527-548 Computer-Assisted Evaluation of Nitroxyl Radical Effect on Biological Activity....Pages 549-571 Aminoxyl Radicals as MRI Contrast Agents....Pages 573-583 Aminoxyl Spin Labels in Clinical Analysis....Pages 585-610 Applications of Spin-Label Techniques at High Pressures....Pages 611-629 Back Matter....Pages 631-636 Bioactive Spin Labels focusses on nitroxyl radicals, their chemistry, biological activity and their application as paramagnetic contrast agents in biomedical research. New EPR techniques for in-vivo studies utilizing nitroxyl radical reagents are described. Recent results on stable nitroxyl radicals as anticancer, antishock, antiaggregant and antischemic drugs are summarized