Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach

Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach covers herbal medicines from the Himalayan mountains. Chapters in this book detail molecular mechanisms and experimental tools and techniques for research on plants in this region. Phytochemical experts guide the readers through the role of Himalayan plants in therapy for metabolic diseases like cancer and diabetes, hepatic diseases, inflammatory diseases, and neurodegenerative diseases. Some chapters focus on diseases and how various plants from Himalayan origin are beneficial in these diseases. This compilation,with professional contributors, aims to inform a wide scientific community from various research fields about basic research on medicinal plants with a focus on Himalayan herbs. The book also serves as a handbook for pharmacologists working on the broad therapeutic aspects of these plants. Cover Title Copyright End User License Agreement Contents Foreword Preface List of Contributors Anticancer Phytochemicals from the Himalayas: Underlying Mechanisms and Chemopreventive Significance in Cancer Anjana Bhatia1, Saroj Arora2, Bikram Singh3 and Avinash Nagpal2,* INTRODUCTION THE INDIAN HIMALAYAS: A TREASURY OF MEDICINAL PLANTS Hypericum Perforatum Linn. Phytochemicals from Hypericum Perforatum and their Cancer Chemopreventive Activities Juniperus sp. Phytochemicals from Juniperus sp. and their Cancer Chemopreventive Activities Lavandula sp. Phytochemicals from Lavender and Cancer Chemoprevention Pinus sp. Phytochemicals from Pinus and their Cancer Chemopreventive Activities CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Hepatoprotective Molecules from Himalayan Plants and their Role in Xenobiotic Mechanisms: A Tabulated Review Kritika Pandit1, Amritpreet Kaur1, Manish Kumar2, Renu Bhardwaj1 and Satwinderjeet Kaur1,* INTRODUCTION CONCLUSION AND FUTURE PERSPECTIVES CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Himalayan Herbs: A Promising Medication Source for Neurodegenerative Diseases Sippy Singh1,* and Durgesh Singh1 INTRODUCTION NEURODEGENERATIVE DISEASES AYURVEDA IN TREATING NEURODEGENERATIVE DISEASES PLANTS OF THE HIMALAYAN REGION CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Antidiabetic Role of Swertia chirayita: Phytochemical and Pharmacological Perspective of a Himalayan Botanical Nikhil Pandey1, Priyanka Mishra1 and Yamini B Tripathi1,* INTRODUCTION PHYTOCHEMISTRY OF SWERTIA CHIRAYITA ANTIDIABETIC PROPERTIES OF SC CONCLUSION AND FUTURE PERSPECTIVES CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Health Promoting Properties of Grewia asiatica and Grewia tenax Berries: A Potential Role in Cancer, Diabetes, and Liver Diseases Prevention Ankita Rajput1, Palvi Sharma1, Hasandeep Singh2, Balbir Singh2, Sarabjit Kaur2,* and Saroj Arora1,* INTRODUCTION Grewia Tenax (Forsk.) Fiori Traditional Uses Phytoconstituents Pharmacological Activity Iron Absorption Activity Hepatoprotective Activity Blood Parameters Grewia Asiatica L Traditional Uses Phytoconstituents Pharmacological Activity Antioxidant Activity Radioprotective Activity Antipyretic, Anti-inflammatory and Analgesic Activities Effect on Blood Alterations Hepatoprotective Activity Anticancer Activity Antidiabetic Activity Antimicrobial Activity Immunomodulatory Effect Anti-dementia CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Medicinal Value of Atropa belladonna L.: A Therapeutic Approach against Various Diseases Palvi Sharma1, Ankita Rajput1, Sukhprit Singh2, Neena Bedi3, Balbir Singh3 and Saroj Arora1,* INTRODUCTION PLANT PROFILE Common Names Description Distribution Traditional Uses PHARMACOLOGICAL EFFECTS Antioxidant Activity Neuro-pharmacological Effects Anti-inflammatory Effect Skin Wound Healing Antimicrobial Activity Anticholinergic Activity Pain Relief and Sedation Anticonvulsant Activity CHEMICAL CONSTITUENTS TOXICITY AND SIDE EFFECTS CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Pharmacological, Therapeutic, and Immunomodulatory Role of Tinospora cordifolia Naina Rajak1, Kavita1, Praveen Kumar1, Shikha Singh2 and Neha Garg1,* INTRODUCTION BIOACTIVE PROPERTIES OF TC EXTRACTS PHYTOCHEMISTRY AND PHARMACOLOGICAL ASPECTS OF TC Chemical Composition Pharmacological Activity of Tinospora cordifolia Anti-cancer Activity Anti-diabetic Activity Anti-toxin Activity Anti-microbial Activity Anti-HIV Activity Anti-arthritic Activity Immunomodulatory Activity Immunomodulatory Activity of TC: Role of Berberine Colorectal Cancer CONCLUSION AND FUTURE PERSPECTIVES LIST OF ABBREVIATIONS CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Immunomodulatory Potential of Himalayan Plant: Withania somnifera Kavita1, Naina Rajak1, Praveen Kumar1, Shikha Singh2 and Neha Garg1,* INTRODUCTION PHYTOCHEMISTRY AND THERAPEUTIC ACTIVITIES OF ASHWAGANDHA Chemical Composition Therapeutic Activities of Withania somnifera Anti-arthritis Activity Anti-diabetic Activity Anti-inflammatory Activity Antineoplastic Agent Anti-oxidant Activity Anti-stress Activity Hemopoietic Effect Rejuvenation Activity Neuromodulatory Activity IMMUNOMODULATORY POTENTIAL OF WITHANIA SOMNIFERA Immunomodulatory Activity of Withaferin A CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Medicinal Plants from the Himalayas Acting on Inflammatory and Oxidative Stress Pathways Priyanka Mishra1, Nikhil Pandey1 and Yamini B Tripathi1,* INTRODUCTION THE LINK AMONG OXIDATIVE STRESS, INFLAMMATION AND CELLULAR PATHOLOGY Medicinal Plants Acting on the Inflammatory Pathway from the Himalayan Range MEDICINAL PLANTS ACTING ON OXIDATIVE STRESS PATHWAY FROM THE HIMALAYAN RANGE Molecular Pathways Affected CONCLUSION AND FUTURE PERESPECTIVES CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Phytochemical Databases and their Relevance to Phytotherapy Shagun Shagun1 and Shyam Kumar Masakapalli1,* INTRODUCTION PHYTOCHEMICAL DATABASES a). Region Specific Databases of Medicinal Plants and Phytochemicals b). Disease-specific Medicinal Plants and Phytochemical Databases c). Other Common Medicinal Plants and Phytochemical Databases d). Himalayan Region-specific Medicinal Plants and Phytochemical Databases PHYTOCHEMICAL DATABASES COMPLEMENT PHYTOTHERAPY RESEARCH DATABASES WITH RELEVANCE TO HIMALAYAN PHYTOCHEMICALS CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Tools and Techniques to Tap the Potential of Himalayan Bioactive Molecules Shagun Shagun1 and Shyam Kumar Masakapalli1,* INTRODUCTION PROFILING OF PHYTOCHEMICALS FROM HIMALAYAN FLORA 1. Extraction of Phytochemicals 2. Multi-analytical Platforms Used for the Identification of Phytochemicals MOLECULAR DOCKING OF THE PHYTOCHEMICALS FROM HIMALAYAN FLORA TO VARIOUS DISEASE TARGETS MOLECULAR DYNAMICS SIMULATION AND BINDING FREE ENERGY CALCULATIONS ASSESSMENT OF ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION, AND TOXICITY PROPERTIES BIOACTIVITY TESTING OF CRUDE EXTRACTS OR SELECTED PHYTOCHEMICALS In Vitro Assays In vivo Assays and Clinical Trials CASE STUDY: MOLECULAR DOCKING STUDY OF THE PHYTOCHEMICALS FROM HIMALAYAN FLORA TO MYCOBACTERIUM TUBERCULOSIS POLYKETIDE SYNTHASE-13 (MTB-PKS 13) SELECTED PHYTOCHEMICALS FROM HIMALAYAN FLORA FOR DOCKING AGAINST PKS-13 OF MTB Himalayan Rhododendron arboreum Petals Phytochemicals Showed Promising Binding Affinities Against Mycobacterium tuberculosis Polyketide Synthase-13 CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Subject Index Back Cover