Bioactive Lipids in Health and Disease (Advances in Experimental Medicine and Biology, 1127)

The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an __in vivo__ overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology Front Matter ....Pages i-viii Front Matter ....Pages 1-1 Diffusion and Transport of Reactive Species Across Cell Membranes (Matias N. Möller, Ernesto Cuevasanta, Florencia Orrico, Ana C. Lopez, Leonor Thomson, Ana Denicola)....Pages 3-19 Characterization of Hydroxy and Hydroperoxy Polyunsaturated Fatty Acids by Mass Spectrometry (Priscilla Bento Matos Cruz Derogis, Adriano B. Chaves-Fillho, Sayuri Miyamoto)....Pages 21-35 Front Matter ....Pages 37-37 Understanding Peroxisome Proliferator-Activated Receptors: From the Structure to the Regulatory Actions on Metabolism (María Lamas Bervejillo, Ana María Ferreira)....Pages 39-57 Diminishing Inflammation by Reducing Oxidant Generation: Nitrated Fatty Acid-Mediated Inactivation of Xanthine Oxidoreductase (Eric E. Kelley)....Pages 59-65 Unfolded Protein Response: Cause or Consequence of Lipid and Lipoprotein Metabolism Disturbances? (Bruno Araújo Serra Pinto, Lucas Martins França, Francisco Rafael Martins Laurindo, Antonio Marcus de Andrade Paes)....Pages 67-82 Front Matter ....Pages 83-83 Arachidonic Acid and Nitroarachidonic: Effects on NADPH Oxidase Activity (Lucía Gonzalez-Perilli, Carolina Prolo, María Noel Álvarez)....Pages 85-95 Lipid Metabolism and Signaling in Platelet Function (Antonio Marcus de Andrade Paes, Renato Simões Gaspar, Eduardo Fuentes, Sergio Wehinger, Iván Palomo, Andrés Trostchansky)....Pages 97-115 Dyslipidemia in Ischemia/Reperfusion Injury (Tamara Mazo, Veronica D’Annunzio, Martin Donato, Virginia Perez, Tamara Zaobornyj, Ricardo J. Gelpi)....Pages 117-130 Epicardial Adipose Tissue in Cardiovascular Disease (Gabriela Berg, Verónica Miksztowicz, Celina Morales, Magalí Barchuk)....Pages 131-143 Front Matter ....Pages 145-145 Bioactive Lipids and the Gut-Brain Axis: Diet as a Modulator of Bioactivity and Diversity of Lipids in the Brain (A. Ledo, B. S. Rocha, J. Laranjinha)....Pages 147-168 Nitroalkylation of α-Synuclein by Nitro-Oleic Acid: Implications for Parkinson’s Disease (Cecilia Chavarría, Andrés Trostchansky, Rosario Durán, Homero Rubbo, José M. Souza)....Pages 169-179 Bioactive Lipids in Inflammation After Central Nervous System Injury (Rubèn López-Vales, Samuel David)....Pages 181-194 Back Matter ....Pages 195-198 "The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology." -- prové de l'editor