Bioactive Heterocycles IV (Topics in Heterocyclic Chemistry, 10)

From the reviews: "This latest volume in the series Topics in Heterocyclic Chemistry is a collection of nine chapters covering a diverse assortment of natural and synthetic nitrogen- and oxygen- containing heterocycles. ... A Subject Index and an Author Index for Volumes 1-10 are included. ... the structural drawings are excellent. ... to academic libraries that are collecting volumes from the Topics in Heterocyclic Chemistry series." (Gordon W. Gribble, Journal of the American Chemical Society, Vol. 130 (19), 2008) This volume contains nine more contributions from expert researchers of the?eld, providing readers with in depth and current research results regarding therespective topics. In the?rst chapter, Flemming et al. review the chemistry, biosynthesis, metabolism and biological activities of tetrahydrocannabinol and its deri- tives. Hansch and Verma contribute to the quantitative structure-activity re- tionship (QSAR) analysis of heterocyclic topoisomerase I and II inhibitors. These inhibitors, knowntoinhibit either enzyme, actasantitumoragentsand are currently used in chemotherapy and in clinicaltrials. In the third chapter, Khan reviews some aspects of molecular modeling studies on biologically active alkaloids, brie?y providing considerations on themodeling approaches. In next chapter, Khan and Ather review different aspects of the microbial transformationsof theimportant nitrogenousmolecules, as they have diverse biological activities. This chapter provides a critical update of the microbial transformations reported in recent years, targeting novel biocatalysts from microbes. In the?fth chapter, Hamdi and Dixneuf describe the synthesis of triazoles andcoumarins molecules andtheirphysiologicalactivities. Maiti and Kumar, in their contribution, review the physicochemical and nucleic acid binding properties of several isoquinoline alkaloids (berberine, palmatine and coralyne) and their derivatives under various environmental conditions. Inchapterseven, Berlinckdescribesvarietiesofpolycyclicdiaminealkaloids such as halicyclamines, 'upenamide, xestospongins, araguspongines, hali- clamines, haliclonacyclamines, arenosclerins, ingenamines and the mad- gamines, etc., and their synthesis as well as biologicalactivities Front Matter....Pages I-XVI Chemistry and Biological Activity of Tetrahydrocannabinol and its Derivatives....Pages 1-42 Quantitative Structure–Activity Relationships of Heterocyclic Topoisomerase I and II Inhibitors....Pages 43-73 Molecular Modeling of the Biologically Active Alkaloids....Pages 75-97 Microbial Transformation of Nitrogenous Compounds....Pages 99-122 Synthesis of Triazole and Coumarin Compounds and Their Physiological Activity....Pages 123-153 Protoberberine Alkaloids: Physicochemical and Nucleic Acid Binding Properties....Pages 155-209 Polycyclic Diamine Alkaloids from Marine Sponges....Pages 211-238 Catechins and Proanthocyanidins: Naturally Occurring O -Heterocycles with Antimicrobial Activity....Pages 239-263 Benzofuroxan and Furoxan. Chemistry and Biology....Pages 265-308 Back Matter....Pages 309-317