Behavioral Pharmacology of Neuropeptides: Oxytocin (Current Topics in Behavioral Neurosciences Book 35)

This volume collects cutting-edge expert reviews in the oxytocin field and will be of interest to a broad scientific audience ranging from social neuroscience to clinical psychiatry. The role of the neuropeptide oxytocin in social behaviors is one of the earliest and most significant discoveries in social neuroscience. Influential studies in animal models have delineated many of the neural circuits and genetic components that underlie these behaviors. These discoveries have inspired researchers to investigate the effects of oxytocin on brain and behavior in humans and its potential relevance as a treatment for psychiatric disorders including borderline personality disorder and autism and schizophrenia spectrum disorders. In fact, there is no established social psychopharmacology in Psychiatry, and oxytocin can be seen as the first endogenous agent specifically addressing social-cognitive impairment in psychiatric disorders, with animal research suggesting that it could be especially efficient in the early postnatal period. From a human perspective, it is crucial to understand more precisely who can benefit from potential oxytocin-related treatments, which outcome measures will best represent their effects, how they should be administered, and what brain mechanisms are likely involved in mediating their effects. This type of “precision medicine” approach is in line with the research domain criteria defined by the U.S. National Institute of Mental Health. Front Matter ....Pages i-ix Front Matter ....Pages 1-1 Molecular Basis of Oxytocin Receptor Signalling in the Brain: What We Know and What We Need to Know (Marta Busnelli, Bice Chini)....Pages 3-29 Oxytocin Modulation of Neural Circuits (Mariela Mitre, Jessica Minder, Egzona X. Morina, Moses V. Chao, Robert C. Froemke)....Pages 31-53 Oxytocin and Olfaction (Lars-Lennart Oettl, Wolfgang Kelsch)....Pages 55-75 Oxytocin and Steroid Actions (Gustav F. Jirikowski, Scott D. Ochs, Jack D. Caldwell)....Pages 77-95 Oxytocin and Social Relationships: From Attachment to Bond Disruption (Oliver J. Bosch, Larry J. Young)....Pages 97-117 Oxytocin and Parental Behaviors (Chihiro Yoshihara, Michael Numan, Kumi O. Kuroda)....Pages 119-153 The Role of Oxytocin in Social Buffering: What Do Primate Studies Add? (Catherine Crockford, Tobias Deschner, Roman M. Wittig)....Pages 155-173 Oxytocin and Aggression (Trynke R. de Jong, Inga D. Neumann)....Pages 175-192 Oxytocin Signaling in Pain: Cellular, Circuit, System, and Behavioral Levels (Pierrick Poisbeau, Valery Grinevich, Alexandre Charlet)....Pages 193-211 Oxytocin and Animal Models for Autism Spectrum Disorder (Shlomo Wagner, Hala Harony-Nicolas)....Pages 213-237 Oxytocin Signaling in the Early Life of Mammals: Link to Neurodevelopmental Disorders Associated with ASD (Françoise Muscatelli, Michel G. Desarménien, Valery Matarazzo, Valery Grinevich)....Pages 239-268 The Multidimensional Therapeutic Potential of Targeting the Brain Oxytocin System for the Treatment of Substance Use Disorders (Michael T. Bowen, Inga D. Neumann)....Pages 269-287 Front Matter ....Pages 289-289 Oxytocin and Human Evolution (C. Sue Carter)....Pages 291-319 Overview of Human Oxytocin Research (Keith M. Kendrick, Adam J. Guastella, Benjamin Becker)....Pages 321-348 Oxytocin and Facial Emotion Recognition (Mark A. Ellenbogen)....Pages 349-374 Oxytocin and Social Cognition (Andreas Ebert, Martin Brüne)....Pages 375-388 Oxytocin and Interpersonal Relationships (Alexandra Patin, Dirk Scheele, Rene Hurlemann)....Pages 389-420 Oxytocin and Human Sensitive and Protective Parenting (Marian J. Bakermans-Kranenburg, Marinus H. van IJzendoorn)....Pages 421-448 Oxytocin and Autism Spectrum Disorders (Hidenori Yamasue, Gregor Domes)....Pages 449-465 Oxytocin and Anxiety Disorders (Michael G. Gottschalk, Katharina Domschke)....Pages 467-498 Oxytocin and Borderline Personality Disorder (Katja Bertsch, Sabine C. Herpertz)....Pages 499-514 Oxytocin and Schizophrenia Spectrum Disorders (Ulrich Ettinger, René Hurlemann, Raymond C. K. Chan)....Pages 515-527 Oxytocin and Prader-Willi Syndrome (Anahid Kabasakalian, Casara J. Ferretti, Eric Hollander)....Pages 529-557 A Precision Medicine Approach to Oxytocin Trials (Elissar Andari, Rene Hurlemann, Larry J. Young)....Pages 559-590 Erratum to: Oxytocin Signaling in Pain: Cellular, Circuit, System, and Behavioral Levels (Pierrick Poisbeau, Valery Grinevich, Alexandre Charlet)....Pages E1-E1 Erratum to: Oxytocin Signaling in the Early Life of Mammals: Link to Neurodevelopmental Disorders Associated with ASD (Françoise Muscatelli, Michel G. Desarménien, Valery Matarazzo, Valery Grinevich)....Pages E3-E3