Behavioral Neuroscience of Orexin/Hypocretin (Current Topics in Behavioral Neurosciences (33))

This issue of __Current Topics in Behavioral Neuroscience__ focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior. This is a fast-moving field, and with the incorporation of novel technologies, new breakthroughs are likely to continue. For example, the use of optogenetic approaches has enabled the identification of the role of orexin-containing neurons in arousal states, critical for higher order functioning. From a clinical perspective, genetic polymorphisms in hypocretin/orexin and orexin receptors are implicated in a number of psychiatric disorders. In addition, advanced clinical trials are currently underway for orexin receptor antagonists in the treatment of insomnia and sleep disorders. We aim to capture a broad audience of basic scientists and clinicians. Front Matter....Pages i-viii The Human Orexin/Hypocretin Receptor Crystal Structures....Pages 1-15 Orexin/Hypocretin Signaling....Pages 17-50 Orexin/Hypocretin and Organizing Principles for a Diversity of Wake-Promoting Neurons in the Brain....Pages 51-74 The Hypocretin/Orexin Neuronal Networks in Zebrafish....Pages 75-92 Hypocretins and Arousal....Pages 93-104 Orexin OX2 Receptor Antagonists as Sleep Aids....Pages 105-136 Roles for Orexin/Hypocretin in the Control of Energy Balance and Metabolism....Pages 137-156 Orexin and Central Modulation of Cardiovascular and Respiratory Function....Pages 157-196 Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders....Pages 197-219 The Role of Orexins/Hypocretins in Alcohol Use and Abuse....Pages 221-246 A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?....Pages 247-281 Hypocretin/Orexin and Plastic Adaptations Associated with Drug Abuse....Pages 283-304 Orexin and Alzheimer’s Disease....Pages 305-322