Behavioral Neurobiology of PTSD (Current Topics in Behavioral Neurosciences Book 38)

This volume focuses on the behavioral neuroscience that supports our understanding of the neurobiology of trauma risk and response. The collection of articles focuses on both preclinical and clinical reviews of (1) state-of-the-art knowledge of mechanisms of posttraumatic stress disorder (PTSD) and co-occurring disorders, (2) the biological and psychological constructs that support risk and resiliency for trauma disorders, and (3), novel treatment strategies and therapeutics on the horizon. Front Matter ....Pages i-x Developmental Contributors to Trauma Response: The Importance of Sensitive Periods, Early Environment, and Sex Differences (Jennifer S. Stevens, Sanne J. H. van Rooij, Tanja Jovanovic)....Pages 1-22 MicroRNAs in Post-traumatic Stress Disorder (Clara Snijders, Laurence de Nijs, Dewleen G. Baker, Richard L. Hauger, Daniel van den Hove, Gunter Kenis et al.)....Pages 23-46 Animal Models of PTSD: A Critical Review (Elizabeth I. Flandreau, Mate Toth)....Pages 47-68 Integrating NIMH Research Domain Criteria (RDoC) into PTSD Research (Ulrike Schmidt, Eric Vermetten)....Pages 69-91 Neurocognition in PTSD: Treatment Insights and Implications (Amy J. Jak, Laura D. Crocker, Robin L. Aupperle, Ashley Clausen, Jessica Bomyea)....Pages 93-116 Neurobiological Programming of Early Life Stress: Functional Development of Amygdala-Prefrontal Circuitry and Vulnerability for Stress-Related Psychopathology (Michelle R. VanTieghem, Nim Tottenham)....Pages 117-136 Subanesthetic Dose Ketamine in Posttraumatic Stress Disorder: A Role for Reconsolidation During Trauma-Focused Psychotherapy? (Cato Veen, Gabriel Jacobs, Ingrid Philippens, Eric Vermetten)....Pages 137-162 Emerging Approaches to Neurocircuits in PTSD and TBI: Imaging the Interplay of Neural and Emotional Trauma (Andrea D. Spadoni, Mingxiong Huang, Alan N. Simmons)....Pages 163-192 Sleep Disruption, Safety Learning, and Fear Extinction in Humans: Implications for Posttraumatic Stress Disorder (Laura D. Straus, Sean P. A. Drummond, Victoria B. Risbrough, Sonya B. Norman)....Pages 193-205 The Future of Contextual Fear Learning for PTSD Research: A Methodological Review of Neuroimaging Studies (Daniel E. Glenn, Victoria B. Risbrough, Alan N. Simmons, Dean T. Acheson, Daniel M. Stout)....Pages 207-228 The Dissociative Subtype of Post-traumatic Stress Disorder: Research Update on Clinical and Neurobiological Features (Jytte van Huijstee, Eric Vermetten)....Pages 229-248 Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder? (Victoria B. Risbrough, Laura M. Glynn, Elysia P. Davis, Curt A. Sandman, Andre Obenaus, Hal S. Stern et al.)....Pages 249-265