Behavioral Neurobiology of Chronic Pain (Current Topics in Behavioral Neurosciences Book 20)

Pain is the most common reason people seek medical help. The treatment of chronic pain is a major unmet clinical need and its impact on health, well-being, society and the economy is immense. Pain is an integrative, whole-systems (patho)physiological phenomenon and behavioural neuroscience plays a key role in advancing our understanding of pain. This volume brings together a series of authoritative chapters written by leading experts in preclinical and clinical aspects of pain neurobiology. Behavioural approaches to the study of persistent or chronic pain in animal models or humans are at the core of the volume, but the anatomical, physiological, neurochemical and molecular mechanisms that underpin behavioural alterations are also emphasized. ​ This volume brings together a series of authoritative chapters written by leading experts in preclinical and clinical aspects of pain neurobiology. It is essential reading for scientists, clinicians and students in need of a comprehensive review of behavioral readouts for the preclinical assessment of chronic pain and analgesic drug efficacy, or those with a general interest in behavioral neuroscience. At the core of this volume are emerging details of the physiology, pharmacology, and psychology of previously neglected types of chronic pain. These types include chronic post-operative pain in humans as well as animal behavioral assays that model the chronic pain of multiple sclerosis, post-herpetic neuralgia, painful diabetic neuropathy, visceral pain, latent central sensitization, and chronic muscle pain. Also emphasized are the complex bidirectional comorbidities between chronic pain and drug dependence, cognitive deficit, stress, anxiety, depression, social interaction, and prior injury history. The novel and exciting ideas introduced within this book, such as endogenous opioid dependence after tissue injury, generate real hope that effective treatment strategies for chronic pain will emerge in the near future. Front Matter....Pages i-viii Persistent Postsurgical Pain: Evidence from Breast Cancer Surgery, Groin Hernia Repair, and Lung Cancer Surgery....Pages 3-29 Behavioral Pharmacology of Pain....Pages 33-56 Animal Models and Pharmacology of Herpetic and Postherpetic Pain....Pages 57-74 Mechanisms and Pharmacology of Neuropathic Pain in Multiple Sclerosis....Pages 75-97 Preclinical Assessment of Pain: Improving Models in Discovery Research....Pages 101-120 Operant Assays for Assessing Pain in Preclinical Rodent Models: Highlights from an Orofacial Assay....Pages 121-145 Animal Models of Diabetes-Induced Neuropathic Pain....Pages 147-170 Visceral Pain....Pages 171-197 Pain and Cognition in Multiple Sclerosis....Pages 201-215 The Self-administration of Analgesic Drugs in Experimentally Induced Chronic Pain....Pages 217-232 The Interaction Between Pain and Social Behavior in Humans and Rodents....Pages 233-250 Neurobiology of Stress-Induced Hyperalgesia....Pages 251-280 Endogenous Analgesia, Dependence, and Latent Pain Sensitization....Pages 283-325 Anatomical and Physiological Factors Contributing to Chronic Muscle Pain....Pages 327-348 Acute and Chronic Pain in Children....Pages 349-366 Back Matter....Pages 367-372