Becker USMLE Step 1 Biochemistry & Genetics

Biochemistry and Genetics Table of Contents Biochemistry Chapter 1 Nucleic Acid Chemistry The Essence of Molecular Biology Nucleic Acid Structure Nomenclature DNA vs. RNA Polymerization Base Pairing Higher Order DNA Structure Chapter 2 DNA Replication Overview of Replication The Cell Cycle The DNA Replication Process Telomeres DNA Editing Chapter 3 Eukaryotic Gene Expression: Transcription Overview of Transcription Types of RNA Genes and Non-coding Regions of DNA Gene Structure Transcription Process RNA Processing Control of Gene Expression at the Transcriptional Level Chapter 4 Euokaryotic Gene Expression: Translation Overview of Translation Requirements for Protein Synthe sis Ribosomes Amino Acids Protein Folding, Posttranslational Modifications, and Targeting Collagen Chapter 5 Mutations and DNA Repair Mutations DNA Repair Chapter 6 Tools of Molecular Biology Techniques of Genetic Analysis Recombinant DNA Technology Cloning Genes Using Reverse Transcription Applications of Gene Cloning Chapter 7 Thermodynamics and Enzyme Kinetics Thermodynamics Kinetics Chapter 8 Introduction to Metabolic Pathways Overview of Metabolic Pathways Integrated Control of Metabolism Chapter 9 Glycoysis Glucose Absorption in the Intestine Glucose Uptake Glycolysis Fructose Metabolism Galactose Metabolism Chapter 10 TCA Cycle and Oxidative Phosphorylation Pyruvate and the TCA Cycle Oxidative Phosphorylation Chapter 11 Glycogen Synthesis and Glycogenolysis Glycogen Glycogenolysis The Hexose Monophosphate Shunt Chapter 12 Lipid Synthesis and Transport Overview of Lipid Synthesis Fatty Acid Structure Fatty Acid Biosynthesis Triglyceride (Triacylglyceroll) Synthesis Cholesterol Synthesis Lipoprotein Metabolism Hyperlipidemias Chapter 13 Lipid Metabolism and Catabolism Lipid Mobilization Fatty Acid Oxidation Ketone Body Metabolism Sphingolipids Chapter 14 Nitrogen Metabolism Overview of Nitrogen Metabolism Removal and Excretion of Amino Groups The Urea Cycle Disorders of Amino Acid Metabolism Heme Synthesis Heme Degradation Chapter 15 Nucleotide Metabolism Overview of Nucleotide Metabolism Pyrimidines Purines Clinical Cases Clinical Case 1 Clinical Case 2 Clinical Case 3 Clinical Case 4 Clinical Case 5 Clinical Case 6 Appendix 1 Genetics Chapter 1 Basic Mendelian Inheritance The Language of Mendelian Inheritance Basics of Pedigree Analysis Modes of Inheritance Chapter 2 Genotype-Phenotype Discordance Factors Affecting Expression of Single-Gene Diseases Factors Complicating Inheritance Patterns Chapter 3 Cytogenetics Overview of Cytogenetics Chromosomal Morphology and Nomenclature Abnormalities of Chromosome Number Structural Abnormalities of Chromosomes Chapter 4 Population Genetics Overview of Population Genetics Hardy-Weinberg Equilibrium Genetic Variables Affecting Hardy-Weinberg Equilibrium Chapter 5 Genetics of Multifactorial Diseases Overview of Multifactorial Diseases Multifactorial Inheritance Chapter 6 Gene Mapping Overview of Gene Mapping Chapter 7 Genetic Diagnosis and Therapy Overview of Genetic Diagnostics Prenatal Genetic Diagnosis Diagnosis of Cytogenetic Abnormalities Direct Genetic Diagnosis Indirect Genetic Diagnosis Gene Therapy