BCL‑2 Protein Family: Essential Regulators of Cell Death (Advances in Experimental Medicine and Biology (687))

In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‐2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism. Homeostatic functions of BCL-2 proteins beyond apoptosis / Nika N. Danial, Alfredo Gimenez-Cassina, and Daniel Tondera Alternative functions of the BCL-2 protein family at the endoplasmic reticulum / Diego Rojas-Rivera ... [et al.] BH3-only proteins and their effects on cancer / Thanh-Trang Vo and Anthony Letai Endoplasmic reticulum stress and BCL-2 family members / Ross T. Weston and Hamsa Puthalakath Targeting survival pathways in lymphoma / Luca Paoluzzi and Owen A. O'Connor The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis / Maria Eugenia Soriano and Luca Scorrano Noncanonical functions of BCL-2 proteins in the nervous system / Heather M. Lamb and J. Marie Hardwick Mitochondria on guard : role of mitochondrial fusion and fission in the regulation of apoptosis / Mariusz Karbowski. In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCLa'2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential therapeutic benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converg