Basic Aspects Of Receptor Biochemistry: Proceedings Of The International Symposium, Vienna, Austria September 10-12, 1982 (journal Of Neural Transmission. Supplementa)

Parkinson's disease is one of the major causes of neurological disability in adult life. It has been encountered in all races, in every region of the world and shows no preference for either sex. In general, its initial manifestations begin in the fifth decade of life. With the world population showing an increase in numbers of people in the older age groups, Parkinson's disease will undoubtedly be encountered with increased frequency in the years to come. Though its cause is unknown, significant strides in understanding its nature and controlling its symptoms have been made during the past two decades. Contained in this volume is a comprehensive review of the present knowledge of Parkinson's disease. Though James Parkinson is credited with the uncovering the illness which now bears his name, and his monograph on the Shaking Palsy written in 1817, is truly a medical classic, descriptions of this disease can be found in medical writings going back to the time of Galen. Indeed, he himself was the first to admit that he was not describing a new disease but bringing an old one to the attention of the medical researchers of his time so that it would become a subject of interest and investigation. Specifically, his objective was the morbid anatomist whose efforts he hoped would bring to light the cause and nature of the disorder. This, then, would become a basis for· treatment or even cure. Front Matter ....Pages I-IX The Normal and Aberrant Development of Synaptic Structures Between Parallel Fibers and Purkinje Cell Dendritic Spines (A. Hirano)....Pages 1-8 High-Resolution Radioautographic Study of Dopamine Binding Sites in the Rat Neostriatum Using 3H-Domperidone (M. Arluison, Marie-Pascale Martres, P. Sokoloff)....Pages 9-24 Neurotransmitter Related Immunocytochemistry of the Human Central Nervous System (J. Pearson, L. Brandeis, M. Goldstein, A. Claudio Cuello)....Pages 25-31 Studies on the Neurotransmitter Binding to Pig Brain Microvessels (W.-D. Rausch, W. Rossmanith, J. Gruber, P. Riederer, K. Jellinger, M. Weiser)....Pages 33-44 Coordination Chemical Aspects of Receptor Biochemistry (H. Noller, Elisabeth Kienzl, P. Riederer)....Pages 45-54 Energetics of Ligand Binding to Receptors (T. J. Franklin)....Pages 55-60 Receptor Blockade and Synaptic Function (D. M. J. Quastel, P. Pennefather)....Pages 61-81 Patch-Clamp Measurements of Elementary Chloride Currents Activated by the Putative Inhibitory Transmitters GABA and Glycine in Mammalian Spinal Neurons (B. Sakmann, O. P. Hamill, J. Bormann)....Pages 83-95 Calmodulin, Ca2+-Antagonists and Ca2+-Transporters in Nerve and Muscle (J. D. Johnson, Laura A. Wittenauer, R. D. Nathan)....Pages 97-111 Adenosine: Transport, Function and Interaction with Receptors in the CNS (G. W. Kreutzberg, M. Reddington, K. S. Lee, P. Schubert)....Pages 113-119 Regulation of Noradrenergic Receptor Systems in Brain that Are Coupled to Adenylate Cyclase (F. Sulser, D. H. Manier, A. J. Janowsky, F. Okada)....Pages 121-130 The Search for Selective Dopaminergic Autoreceptor Agonists (S. Hjorth, A. Carlsson, D. Clark, K. Svensson, H. Wikström, D. Sanchez et al.)....Pages 131-137 Evidence That the D-2 Dopamine Receptor in the Intermediate Lobe of the Rat Pituitary Gland Is Associated with an Inhibitory Guanyl Nucleotide Component (T. E. Cote, E. A. Frey, C. W. Grewe, J. W. Kebabian)....Pages 139-147 Dopamine Receptor Sites and States in Human Brain (Susan George, Karen Binkley, P. Seeman)....Pages 149-156 Biochemical and Pharmacological Differentiation of Neuroleptic Effect on Dopamine D-1 and D-2 Receptors (J. Hyttel, Anne Vibeke Christensen)....Pages 157-164 Evidence for the Existence of Receptor—Receptor Interactions in the Central Nervous System. Studies on the Regulation of Monoamine Receptors by Neuropeptides (K. Fuxe, L. F. Agnati, F. Benfenati, M. Celani, I. Zini, M. Zoli et al.)....Pages 165-179 (3,4-Dihydroxyphenylimino)-2-Imidazoline (DPI) and Its Action at Noradrenergic and Dopaminergic Receptors in the Nucleus Accumbens of Rats: Mesolimbic Catecholamine Receptors and Hyperactivity (A. R. Cools, S. K. Oosterloo)....Pages 181-188 Interactions of Ergot Compounds with Dopamine Receptors and Endocrine Functions (E. Flückiger)....Pages 189-204 Long-Term Adaptive Changes in Striatal Dopamine Function in Response to Chronic Neuroleptic Intake in Rats (P. Jenner, R. Kerwin, N. M. J. Rupniak, K. Murugaiah, M. D. Hall, S. Fleminger et al.)....Pages 205-212 Cotransmitters: Pharmacological Implications (A. Guidotti, L. Saiani, B. C. Wise, E. Costa)....Pages 213-225 Multiple Opiate Receptors and Their Functional Significance (A. Herz)....Pages 227-233 Peptidases Involved in the Inactivation of Exogenous and Endogenous Enkephalins (J. C. Schwartz, Sophie de la Baume, C. C. Yi, P. Chaillet, Hélène Marcais-Collado, J. Costentin)....Pages 235-243 D2-Protein and D3-Protein as Markers for Synaptic Turnover and Concentration (O. S. Jørgensen)....Pages 245-255 Therapeutic Potentials of Centrally Acting Dopamine and α2-Adrenoreceptor Agonists (M. Goldstein, J. Engel, A. Lieberman, I. Regev, A. Bystritsky, S. Mino)....Pages 257-263 Dopamine Receptor Changes in Schizophrenia in Relation to the Disease Process and Movement Disorder (A. J. Cross, T. J. Crow, I. N. Ferrier, E. C. Johnstone, R. M. Mccreadie, F. Owen et al.)....Pages 265-272 Preliminary Studies of Human Cortical 5-HT2 Receptors and Their Involvement in Schizophrenia and Neuroleptic Drug Action (G. P. Reynolds, M. N. Rossor, L. L. Iversen)....Pages 273-277 Brain Receptor Changes in Parkinson’s Disease in Relation to the Disease Process and Treatment (U. K. Rinne, J. O. Rinne, J. K. Rinne, K. Laakso, A. Laihinen, P. Lönnberg)....Pages 279-286 Serotonin Binding in Rat Brain: Circadian Rhythm and Effect of Sleep Deprivation (W. Wesemann, N. Weiner, M. Rotsch, E. Schulz)....Pages 287-294 General Properties of 14C-L-Valine-Binding to Human Brain Tissue (P. Riederer, E. Kienzl, K. Jellinger, H. Noller, G. Kleinberger)....Pages 295-306 5-Hydroxytryptamine Receptors in Neurones and Glia (G. Fillion, Dominique Beaudoin, Maria-Paule Fillion, J.-C. Rousselle, Christine Robaut, Y. Netter)....Pages 307-317 Pharmacological and Therapeutic Actions of GABA Receptor Agonists (B. Zivkovic, B. Scatton, P. Worms, K. G. Lloyd, G. Bartholini)....Pages 319-326 A Possible Relationship Between Folic Acid Neurotoxicity and Cholinergic Receptors in the Pyriform Cortex and Amygdala (P. L. McGeer, Edith G. McGeer, T. Nagai, P.-T. Wong)....Pages 327-344 Association of Proteins Irreversibly Labeled by 3H-Flunitrazepam with Different Benzodiazepine Receptors (W. Sieghart)....Pages 345-352 Tubocurarine, a Partial Agonist for Cholinergic Receptors (A. Trautmann)....Pages 353-361 Differentiation—Dependent Changes of the Nicotinic Acetylcholine Receptor and Other Synapse-Associated Proteins (V. Witzemann)....Pages 363-368 Cellular Mechanism Involved in the Synthesis of Cyclic GMP in Nervous Tissues (T. Deguchi, S. Ohsako, M. Nakane, M. Ichikawa, M. Yoshioka)....Pages 369-378 Closing Remarks (M. Goldstein)....Pages 379-380 Back Matter ....Pages 381-392