Basic And Clinical Concepts Of Lung Cancer (cancer Treatment And Research)

The last volume dealing with lung cancer in this series in Cancer Treatment and Research was published in 1986 and entitled Lung Cancer: Basic and Clinical Aspects. The present book continues the outline of the previous volume by presenting up-to-date information on lung cancer in critical reviews of new important basic and clinical concepts of lung cancer. The present volume has broadened the scope by also including chapters dealing with issues such as epidemiology, prophylaxis, and histopathology of lung cancer. The content of the book thus reflects the increasing awareness of a global disease that is more and more in focus, not only scientifically but also politically. The latter fact results increasingly in changes in health legisla­ tion, with prevention measures influencing everyday life. The great interest in the disease is natural, considering that more than one patient dies from lung cancer every minute globally. The first chapter is from the Cancer Unit, WHO, Geneva, and describes in detail the epidemiologic features of lung cancer, which is the second most frequent cancer in the world with 660,500 new cases annually; it will soon surpass stomach cancer as the leader. Thirty-one percent of the cases occur in developing countries, where the increase is especially dramatic. Front Matter....Pages i-xv Lung Cancer in Developed and Developing Countries....Pages 1-14 The Impact of Prophylactic Methods in the Control of Lung Cancer in the U.S.A.....Pages 15-33 Advances in the Diagnosis of Lung Tumors....Pages 35-51 Observer Variability Studies of the WHO Classification of Lung Cancer....Pages 53-69 Immunohistochemistry of Lung Cancer: Cell differentiation and Growth Properties....Pages 71-87 Oncogenes and Human Lung Cancer....Pages 89-106 Autocrine Growth Factors and Lung Cancer....Pages 107-122 Cytogenetic Abnormalities in Lung Cancer....Pages 123-136 Clinical Correlation of Tumor Endocrine Markers in Lung Cancer....Pages 137-149 Can Human Small-Cell Lung Cancer Cell Lines be Applied for Optimizing Chemotherapy?....Pages 151-172 Interferons and Lung Cancer: Preclinical and Clinical Investigations....Pages 173-182 Current Staging of Lung Cancer: An Overview of Current and Newer Approaches....Pages 183-213 Prognostic Factors in Adenocarcinoma of the Lung....Pages 215-243 Surgical Adjuvant Therapy of Non-Small-Cell Lung Cancer....Pages 245-258 High-dose Chemotherapy of Small-Cell Lung Cancer With and Without Bone Marrow Transplantation....Pages 259-274 CNS Therapy in Small-Cell Lung Cancer....Pages 275-299 Late Complications Associated with the Treatment of Small-Cell Lung Cancer....Pages 301-323 Psychosocial Aspects of Patients with Lung Cancer in Controlled Clinical Trials....Pages 325-355 Back Matter....Pages 357-368