Basic and clinical aspects of immunity to insulin : Proceedings, International Workshop, September 28-October 1, 1980, Konstanz

Linguistic variation is a topic of ongoing interest to the field. Its description and its explanations continue to intrigue scholars from many different backgrounds. By taking a deliberately broad perspective on the matter, covering not only crosslinguistic and diachronic but also intralinguistic and interspeaker variation and examining phenomena ranging from negation over connectives to definite articles in well- and lesser-known languages, the volume furthers our understanding of variation in general. The papers offer new insights into, among other things, the theoretical notion of comparative concepts, the social or mental nature of language structure, the areal factor in lexical typology and the diachronic implications of semantic maps. The collection will thus be of relevance to typologists and historical linguists, as well as to people studying variation within the areas of cognitive and functional linguistics. PREFACE LIST OF PARTICIPANTS CONTENTS SECTION I. BASIC ASPECTS OF IMMUNITY TO INSULIN Introduction: Insulin as a tool for the study of immunological problems Genetic control of the immune response to insulin Analysis of the in vitro induction of insulin-specific helper T cells Immunogenic determinants of insulin: Synthesis and immunogenicity of the A-chain loop peptides of beef insulin Analysis of H-2 gene regulation of the response of T lymphocytes to insulin using synthetic antigenic determinants and anti-idiotypes Ir gene control of the insulin-specific immune response in mice Influence of insulin modification upon the immune response to insulin Function and complementation of Ir genes controlling the responsiveness of mice to insulin The XID gene controls Ia.W39 associated immune response gene function for insulin induced T cell activation Induction of immunity and suppression by pig insulin in mice Genetic control of anti-insulin responses is associated with activation of different T-cell sets Suppression of insulin responses in vitro Immune response phenotype of insulin-presenting cells modified by insertion of H-2 gene products into cell membranes Differences in insulin antibodies induced with varying antigenic forms Mouse hybridoma antibody recognition of the insulin molecule SECTION II. CLINICAL ASPECTS OF IMMUNITY TO INSULIN Clinical aspects of immunity to insulin Antibody production during insulin therapy - patterns of response and clinical sequels Studies of the immunogenicity of chromatographically purified insulins in Type-I and Type-II diabetics Genetic control of the IgE response to insulin HLA-DR association of humoral immunoresponsiveness to insulin in insulin-dependent (Type I) diabetes mellitus Insulin antibody formation following conventional or monocomponent insulin treatment is influenced by genes of the HLA-DR locus A study of HLA alloantigen frequencies in insulin allergic and non-allergic diabetics Morphologic changes in pancreas islets after active or passive immunization against insulin: a review The role of autoimmune processes in the development of insulin-dependent diabetes mellitus in mice treated with streptozotocin Effect of insulin-binding antibodies of free insulin in plasma and tissue after subcutaneous injection. A model study Immunogenicity of insulin in relation to its physicochemical properties Potentation of insulin immunogenicity by different types of adjuvant Use of modified insulins for the separation of insulin antibodies by affinity chromatography The immunogenicity of insulin from our point of view SECTION III. CHEMISTRY TO INSULIN Preparation of insulins with modified N-terminals by semisynthesis and chemical modification of the native hormone Synthesis of insulin analogues Modification of the C-terminal region of insulin SUBJECT INDEX AUTHOR INDEX