Barriers and Fluids of the Eye and Brain

This book describes the latest findings on the control of the fluid environment of the eye and the brain. The eye is considered from its multiple interfaces. Carbonic anhydrase, which forms a bridge between the eye and CSF, and the secretion and development of its drainage is reviewed. The blood-brain barrier is considered from the cerebral capillary, and recent findings with homologous molecules refute the earlier studies with 'foreign' tracers. A final chapter gives a fascinating glimpse of the future with a description of the latest imaging techniques used in neurological diagnosis. Front Matter....Pages i-xxix Membrane Transport in Ocular Epithelia....Pages 1-13 Transport Functions of the Blood—Ocular and Blood—Brain Barriers, and the Microenvironment of Neuronal and non-neuronal Tissues....Pages 14-23 Ocular Pulsatile Blood Flow in Healthy and Diabetic Eyes....Pages 24-29 Physiology of the Vitreous: A Personal View....Pages 30-36 Role of Carbonic Anhydrase in Aqueous Humour and Cerebrospinal Fluid Formation....Pages 37-48 Pharmacological Manipulation of Cerebrospinal Fluid Secretion....Pages 49-58 Structural, Ultrastructural and Functional Correlations among Local Capillary Systems within the Brain....Pages 59-71 Effects of Phenylephrine and Dopamine on Locomotor Activity and Permeability of the Blood-Brain Barrier of Mice Exposed to Lead from Birth....Pages 72-81 Mechanisms Regulating Peptide Levels in the Cerebrospinal Fluid....Pages 82-105 Blood—Brain Barrier Permeability to Peptides and Proteins....Pages 106-115 Drainage of Cerebrospinal Fluid During Development and in Congenital Hydrocephalus....Pages 116-127 Development of the Blood—Brain Barrier to Macromolecules....Pages 128-155 Pathophysiology of Communicating Hydrocephalus: Information Provided by the New Imaging Modalities....Pages 156-183 Opening of the Blood—Brain Barrier to D-Mannitol Induced by Sensorimotor Cortical Lesions in the Anaesthetized Guinea-pig....Pages 184-187 Uptake of Thiamine by the Isolated Perfused Sheep Choroid Plexus....Pages 188-191 Epileptogenic Activity of Metaphitinduced Audiogenic Seizure in Small Rodents....Pages 192-197 Anticonvulsant Effects of Phencyclidine and PCP-like Drugs on Audiogenic Seizures Induced by Metaphit in Mice....Pages 198-202 Cotransport of Sodium, Potassium and Chloride in the Isolated Choroid Plexus....Pages 203-207 Effect of Congenital Hydrocephalus on Cortical Structure in the H-Tx Rat....Pages 208-209 Role of the Blood—Brain Barrier in Immunopathogenesis of Experimentally Induced Autoimmune Demyelination....Pages 210-212 Back Matter....Pages 213-219