Avian immunology : [proceedings of the International Conference on Avian Immunology, held at the University of Hawaii, Honolulu, Hawaii, March 12-13, 1977

The ontogeny of lymphoid cells seems the most appropriate place to start. The early events in T and B cell ontogeny are still confusing. There seems to be no agreement on the data and on the semantics of the question of progenitor vs. stem cells. Nevertheless, we are beginning to understand more about progenitor cells which are committed to particular cell lines, and about stem cells in the sense of having almost unlimited capability of giving rise to undifferentiated progeny. An important future development will be to determine the nature of the substances that attract stem cells and which are produced by specialized thymus epithelium, and perhaps by the bursa. The way stem cells recognize these signals is an important question to answer. Not predictable from mammalian models has been the observation that there is a lack of cells called into the bursa even before the signal for entry of stem cells has been shut off. A likely model suggested that after a certain point in development there were no longer any cells capable of migrating into the bursa and becoming B cells. A fascinating possibility is the suggestion that a cell comes into the bursa, is not committed, then can still wander into the thymus. This cell does not appear to have B cell characteris­ tics; that is, immunoglobulin is not expressed on its surface. Front Matter....Pages i-xv Front Matter....Pages 1-1 Ontogeny of Myelopoietic Precursor Cells in the Chicken Embryo....Pages 3-11 Ontogeny of Hemopoietic Colony-Forming Units in the Chick Embryo Spleen....Pages 13-28 Differentiation of the Primary Lymphoid Organs in Avian Embryos: Origin and Homing of the Lymphoid Stem Cells....Pages 29-37 Cell Transplantation into Immunodeficient Chicken Embryos Reconstituting Capacity of Different Embryonic Cells....Pages 39-45 Migration Patterns of Avian Embryonic Bone Marrow Cells and Their Differentiation to Functional T and B Cells....Pages 47-59 Unique Aspects of Immunoglobulin Expression During Early B Cell Differentiation in the Chicken....Pages 61-72 Analysis of Immunoglobulin Receptors during Antigen-Induced Maturation of B Cells....Pages 73-83 Front Matter....Pages 85-85 The Production of a Lymphocyte Inhibitory Factor (LyIF) by Bursal and Thymic Lymphocytes....Pages 87-98 Detergent Solubilization of B-Lymphocyte Immunoglobulin....Pages 99-107 Association of Lymphocyte Alloantigen Genotypes with Levels of Immune Responses....Pages 109-120 Rosette Formation in Chicks: With Special Reference to QRBC-Rosettes....Pages 121-133 Front Matter....Pages 135-135 Protein-Induced Neonatal Specific and Non-Specific Immunosuppression....Pages 137-145 The Role of the Adherent Cell in Antigen-Antibody Complex Induced Immune Unresponsiveness....Pages 147-154 Infectious Agammaglobulinemia: Suppressor T Cells with Specificity for Individual Immunoglobulin Classes....Pages 155-159 Further Characterization of the Sensitizing Bursa Cells and of the Target for Suppression in the Transfer of Agammaglobulinemia....Pages 161-173 Regulatory Lymphocytes from Anti-μ Bursectomized Agammaglobulinemic Chickens....Pages 175-185 Regulatory Lymphocytes in T Cell Functions in Chickens....Pages 187-195 Inherited Immunodeficiency in Chickens: A Model for Common Variable Hypogammaglobulinemia in Man?....Pages 197-205 Front Matter....Pages 207-207 Isolation and Partial Characterization of the Major Histocompati-Bility Antigen in the Chicken....Pages 209-220 Some Recent Recombinants at the B Locus....Pages 221-225 Front Matter....Pages 207-207 Histocompatibility Requirements for Cellular Cooperation in the Chicken....Pages 257-265 Allo-Aggression in Chickens: Analysis of the B-Complex by Means of GVH Splenomegaly and by Inhibitory Antibodies....Pages 267-274 Cell Transfer Studies with the DK/OR Inbred Chicken Lines....Pages 275-285 Role of the Major Histocompatibility Complex in Resistance to Marek’s Disease: Restriction of the Growth of JMV-MD Tumor Cells in Genetically Resistant Birds....Pages 287-298 The Influence of the Major Histocompatibility Locus on Marek’s Disease in the Chicken....Pages 299-307 Genetic and Cellular Control of Spontaneous Autoimmune Thyroiditis in OS Chickens....Pages 309-318 Syngeneic Inbred Lines of Chickens and their Use in Immunogenetics....Pages 319-327 The structure of the Major Histocompatibility Complex of the Chicken....Pages 227-232 Immune Response Genes in Chickens: The Multifarious Responsiveness to (T, G)-A--L....Pages 233-243 Immune Response and Adult Mortality Associated with the B Locus in Chickens....Pages 245-256 Front Matter....Pages 329-329 Induction in B2/B2 Chickens of Immunity to Transplantable Carcinogen-Induced Fibrosarcomas Mediated by T-Cell Monocyte Cooperation: Role of Delayed Hypersensitivity to Unrelated Antigens....Pages 331-343 Role of Tumor Antigen in Vaccine Protection in Marek’s Disease....Pages 345-353 Immune Responses and Prevention of Lymphoid Leukosis Tumors in Chickens Fed an Androgen Analog....Pages 355-362 Front Matter....Pages 363-363 Genetic Polymorphism of Chicken 7S Immunoglobulins....Pages 365-372 A Note on Unexpected Chicken 7S Immunoglobulin Allotypes....Pages 373-380 Chicken High Molecular Weight Immunoglobulin (IgM) Allotypes: Localization on the Heavy Chains and Proposed Nomenclature....Pages 381-390 Comparison of the Microenvironment of Chicken and Rabbit Antibody Active Sites....Pages 391-401 Back Matter....Pages 403-407