Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging : Volume 6- Regulation of Autophagy and Selective Autophagy

Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus. The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored. This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinsons, Huntingtons, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes. • Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss recent developments in this rapidly-advancing field • Discuses role of autophagy in immunity, with coverage of toll-like receptors as activators for autophagy; role in antigen processing; and control of production and secretion of il-1B • Covers role of autophagy receptors in mitophagy; role of parkin and pink1 in mitochondrial quality control; and the degradation of endocytosed gap junctions • Organized for readers into easy-to-access sections: autophagy and molecular mechanisms; autophagy and intracellular pathogens; autophagy and immunity; and general applications Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus. The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored. This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn s Disease, Gaucher Disease, Huntington s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy s effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes. Bings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss recent developments in this rapidly-advancing fieldDiscuses role of autophagy in immunity, with coverage of toll-like receptors as activators for autophagy; role in antigen processing; and control of production and secretion of il-1BCovers role of autophagy receptors in mitophagy; role of parkin and pink1 in mitochondrial quality control; and the degradation of endocytosed gap junctionsOrganized for readers into easy-to-access sections: autophagy and molecular mechanisms; autophagy and intracellular pathogens; autophagy and immunity; and general applications" Content: Front-matter, Pages i,iii Copyright, Page iv Dedication, Page v Mitophagy and Biogenesis, Page vii Dedication, Page ix Autophagy and Cancer, Page xi Foreword, Page xvii, Roberta A. Gottlieb Preface, Pages xix-xxi, M.A. Hayat Contributors, Pages xxiii-xxiv, Bernadette Carroll, Patrice Codogno, María I. Colombo, Thomas M. Durcan, Leopold Eckhart, Audrey Esclatine, Matthias M. Falk, Gema Frühbeck, Masayo Fujita, Ghita Ghislat, Devrim Gozuacik, Charles Grose, James Harris, Makoto Hashimoto, M.A. Hayat, Graeme Hewitt, Yoshifumi Iwamaru, Sarah A. Jones, John H. Kehrl, Hiroshi Kitani, Erwin Knecht, et al. Abbreviations and Glossary, Pages xxv-xxxiii Autophagy: Volume 1 – Contributions, Page xxxv Autophagy: Volume 2 – Contributions, Page xxxvii Autophagy: Volume 3 – Contributions, Page xxxix Autophagy: Volume 4 – Contributions, Page xli Autophagy: Volume 5 – Contributions, Page xliii Chapter 1 - Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 6, Pages 1-51, M.A. Hayat Chapter 2 - Regulation of Autophagy by Amino Acids, Pages 55-68, Séverine Lorin, Alfred J. Meijer, Patrice Codogno Chapter 3 - Regulation of Autophagy by Amino Acid Starvation Involving Ca2+, Pages 69-79, Ghita Ghislat, Erwin Knecht Chapter 4 - Regulation of Autophagy by microRNAs, Pages 81-101, Kumsal Ayse Tekirdag, Deniz Gulfem Ozturk, Devrim Gozuacik Chapter 5 - Mechanisms of Cross-Talk between Intracellular Protein Degradation Pathways, Pages 103-119, Graeme Hewitt, Bernadette Carroll, Viktor I. Korolchuk Chapter 6 - Cross-Talk between Autophagy and Apoptosis in Adipose Tissue: Role of Ghrelin, Pages 121-131, Amaia Rodríguez, Leire Méndez-Giménez, Gema Frühbeck Chapter 7 - Intracellular Pathogen Invasion of the Host Cells: Role of α-Hemolysin- Induced Autophagy, Pages 135-144, María Milagros López de Armentia, María I. Colombo Chapter 8 - Modulation of Autophagy by Herpesvirus Proteins, Pages 145-158, Marion Lussignol, Audrey Esclatine Chapter 9 - Autophagy Induced by Varicella-Zoster Virus and the Maintenance of Cellular Homeostasis, Pages 159-167, Charles Grose Chapter 10 - Autophagy and Hepatitis B Virus, Pages 169-176, Yongjun Tian, Lin-ya Wang, Jing-hsiung James Ou Chapter 11 - Toll-Like Receptors Serve as Activators for Autophagy in Macrophages Helping to Facilitate Innate Immunity, Pages 179-189, Ali Vural, Chong-Shan Shi, John H. Kehrl Chapter 12 - Autophagy in Antigen Processing for MHC Presentation to T Cells, Pages 191-199, Christian Münz Chapter 13 - Autophagy Controls the Production and Secretion of IL-1β: Underlying Mechanisms, Pages 201-209, Celia Peral de Castro, Sarah A. Jones, James Harris Chapter 14 - Role of Autophagy in P2X7 Receptor-Mediated Maturation and Unconventional Secretion of IL-1β in Microglia, Pages 211-222, Takato Takenouchi, Kazunari Sekiyama, Mitsutoshi Tsukimoto, Yoshifumi Iwamaru, Masayo Fujita, Shuei Sugama, Hiroshi Kitani, Makoto Hashimoto Chapter 15 - Autophagy Restricts Interleukin-1β Signaling via Regulation of P62 Stability, Pages 223-229, Jongdae Lee, Eyal Raz Chapter 16 - Roles of Autophagy in the Thymic Epithelium, Pages 231-240, Leopold Eckhart, Supawadee Sukseree Chapter 17 - The Role of Autophagy Receptors in Mitophagy, Pages 243-256, Mija Marinković, Ivana Novak Chapter 18 - The Role of Parkin and PINK1 in Mitochondrial Quality Control, Pages 257-271, Matthew Y. Tang, Thomas M. Durcan Chapter 19 - Autophagy Degrades Endocytosed Gap Junctions, Pages 273-285, Matthias M. Falk Index, Pages 287-294

Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus.

The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored.

This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge.

Volumes in the Series

Provides an examination of the role of autophagy in health and disease. Suitable for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases, this four-volume work offers a guide to cellular processes.