اتوفاژی: سرطان، سایر پاتولوژی‌ها، التهاب، ایمنی، عفونت و پیری. جلد سوم - میتوفاژی

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. * Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field * Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level * Organized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosis * Explores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast Content: Front-matter , Pages i,iii Copyright , Page iv Dedication , Page v Dedication , Page vii Preface , Pages xv-xvi , M.A. Hayat Contributors , Pages xvii-xix , Nadezda Apostolova, Baikuntha Aryal, Guy Berchem, Martin R. Berger, Leandro Boonzaaier, Marie-Agnès Bringer, Fathia Mami Chouaib, Salem Chouaib, Courtney Choutka, Arlette Darfeuille-Michaud, Tracy A. Denison, Lindsay DeVorkin, Álvaro F. Fernández, Eleonora Franzetti, Yanira Gonzalez, Sharon M. Gorski, Meriem Hasmim, Jan-Hendrik S. Hofmeyr, Fuyuhiko Inagaki, Bassam Janji, Amrita Kabi, et al. Abbreviations and Glossary , Pages xxi-xxix Autophagy: Volume 1–Contributions , Page xxxi Autophagy: Volume 2–Contributions , Page xxxiii List of Contributions Projected in Volume 4 , Page xxxv Chapter 1 - Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1–4 , Pages 1-35 , M.A. Hayat Chapter 2 - Autophagic Flux, Fusion Dynamics, and Cell Death , Pages 39-56 , Ben Loos, Jan-Hendrik S. Hofmeyr, Kristian Müller-Nedebock, Leandro Boonzaaier, Craig Kinnear Chapter 3 - Architecture of the Atg12–Atg5–Atg16 Complex and its Molecular Role in Autophagy , Pages 57-65 , Nobuo N. Noda, Fuyuhiko Inagaki Chapter 4 - The Molecular Mechanisms Underlying Autophagosome Formation in Yeast , Pages 67-77 , Hayashi Yamamoto, Yoshinori Ohsumi Chapter 5 - Role of Autophagy in Cell Survival in Liver Injury , Pages 81-92 , Nadezda Apostolova Chapter 6 - Polymorphisms in Autophagy-Related Genes in Crohn’s Disease: Impact on Intracellular Bacteria Persistence and Inflammatory Response , Pages 93-110 , Marie-Agnès Bringer, Pierre Lapaquette, Hang Nguyen, Arlette Darfeuille-Michaud Chapter 7 - Functional Relevance of Autophagins in Life and Disease , Pages 111-119 , Álvaro F. Fernández, Carlos López-Otín Chapter 8 - Strategies to Block Autophagy in Tumor Cells , Pages 121-130 , Lindsay DeVorkin, Julian J. Lum Chapter 9 - Autophagic Dysfunction in Gaucher Disease and its Rescue by Cathepsin B and D Proteases , Pages 131-146 , Marialetizia Motta, Massimo Tatti, Rosa Salvioli Chapter 10 - Cargo Recognition Failure Underlies Macroautophagy Defects in Huntington’s Disease , Pages 147-162 , Guomei Tang, David Sulzer Chapter 11 - Hepatitis C Virus Infection, Autophagy, and Innate Immune Response , Pages 163-172 , Shubham Shrivastava, Ratna B. Ray Chapter 12 - Geranylgeranoic Acid Induces Incomplete Autophagy but Leads to the Accumulation of Autophagosomes in Human Hepatoma Cells , Pages 173-185 , Yoshihiro Shidoji Chapter 13 - Defense Against Proteotoxic Stress in the Heart: Role of p62, Autophagy, and Ubiquitin–Proteasome System , Pages 187-201 , Huabo Su, Xuejun Wang Chapter 14 - Elimination of Intracellular Bacteria by Autophagy , Pages 203-210 , Tamaki Yano, Shoichiro Kurata Chapter 15 - Protein Phosphatase 2A Has Positive and Negative Roles in Autophagy , Pages 211-225 , Amrita Kabi, Christine McDonald Chapter 16 - Erufosine Induces Autophagy and Apoptosis in Oral Squamous Cell Carcinoma: Role of the Akt–mTOR Signaling Pathway , Pages 229-245 , Vaishali Kapoor, Maya M. Zaharieva, Martin R. Berger Chapter 17 - Emerging Role of Hypoxia-Induced Autophagy in Cancer Immunotherapy , Pages 247-262 , Bassam Janji, Muhammad Zaeem Noman, Elodie Viry, Meriem Hasmim, Yosra Messai, Guy Berchem, Fathia Mami Chouaib, Salem Chouaib Chapter 18 - Involvement of Autophagy and Apoptosis in Studies of Anticancer Drugs , Pages 263-287 , Bo Liu, Liang Ouyang Chapter 19 - Autophagy-Based Protein Biomarkers for In Vivo Detection of Cardiotoxicity in the Context of Cancer Therapy , Pages 289-307 , Baikuntha Aryal, Tracy A. Denison, Yanira Gonzalez, V.Ashutosh Rao Chapter 20 - Inhibition of mTOR Pathway and Induction of Autophagy Block Lymphoma Cell Growth: Role of AMPK Activation , Pages 309-320 , Wang Li, Zhao Wei-Li Chapter 21 - Autophagy Regulates Osteoarthritis-Like Gene Expression Changes: Role of Apoptosis and Reactive Oxygen Species , Pages 323-331 , Koji Takayama, Takehiko Matsushita Chapter 22 - The Key Role of Autophagy and its Relationship with Apoptosis in Lepidopteran Larval Midgut Remodeling , Pages 333-349 , Eleonora Franzetti, Davide Romanelli, Gianluca Tettamanti Chapter 23 - Interferon Regulatory Factor 1 Regulates both Autophagy and Apoptosis in Splenocytes during Sepsis , Pages 351-368 , Lemeng Zhang, Allan Tsung Chapter 24 - The Interplay between Autophagy and Apoptosis , Pages 369-383 , Lindsay DeVorkin, Courtney Choutka, Sharon M. Gorski Index , Pages 385-395

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections.

Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.

This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process.

• Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway, or both
• Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
• Covers recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections. Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process. Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway, or bothIntroduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammationCovers recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagy presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases.

This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

• Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field
• Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control
• Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level
• Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease Annotation Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagypresents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field . Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control. Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level . Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections.

Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

• Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field
• Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level
• Organized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosis
• Explores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast
  

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections.

Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.

• Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or both
• Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation
• States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or bothIntroduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. This title offers a guide to both cellular processes while inciting researchers to explore their potentially important connection. This book aids in understanding the importance and necessity of the role of autophagy in health and disease, especially in the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. It acts as a guide to both cellular processes and their potentially important connections. Provides an examination of the role of autophagy in health and disease. Suitable for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases, this four-volume work offers a guide to cellular processes.