Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging : Volume 2 - Role in General Diseases

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections. Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process. Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway, or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Covers recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Content: Front-matter , Pages i,iii Copyright , Page iv Dedication , Page v Dedication , Page vii Preface , Pages xv-xviii , M.A. Hayat Contributors , Pages xix-xxi , Satoko Arakawa, Mohammad Aslam Khan, Peter O. Bauer, Riccardo Bernasconi, Sébastien Besteiro, Martine Biard-Piechaczyk, Ana M. Botero, Arthur I. Cederbaum, Steve S.-L. Chen, Xi Chen, Swati Choksi, Robert Clarke, Anna-Mart Engelbrecht, Daniel A. Escobar, Lucile Espert, Hernando Gomez, M.A. Hayat, Ming-Xiao He, Shanshan He, You-Wen He, et al. Abbreviations and Glossary , Pages xxiii-xxxi Autophagy: Volume 1 – Contributions , Page xxxiii List of Contributions Projected in Volumes 3–4 , Page xxxv Chapter 1 - Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volumes 1–4 , Pages 1-36 , M.A. Hayat Chapter 2 - Selective Autophagy: Role of Interaction between the Atg8 Family Interacting Motif and Atg8 Family Proteins , Pages 39-48 , Nobuo N. Noda, Fuyuhiko Inagaki Chapter 3 - Mammalian Autophagy Can Occur Through an Atg5/Atg7-Independent Pathway , Pages 49-58 , Shigeomi Shimizu, Satoko Arakawa, Yuya Nishida, Hirofumi Yamaguchi, Tatsushi Yoshida Chapter 4 - Selective Autophagy: Role of Ubiquitin and Ubiquitin-Like Proteins in Targeting Protein Aggregates, Organelles, and Pathogens , Pages 59-88 , Vladimir Rogov, Vladimir Kirkin Chapter 5 - Ubiquitin and p62 in Selective Autophagy in Mammalian Cells , Pages 89-103 , Kelsey B. Law, Peter K. Kim Chapter 6 - Role of the Golgi Complex and Autophagosome Biogenesis in Unconventional Protein Secretion , Pages 105-114 , Sunaina Singh, Ravi Manjithaya Chapter 7 - Induction of Autophagy in HIV-1-Uninfected Cells: Role of Fusogenic Activity of gp41 , Pages 117-127 , Lucile Espert, Martine Biard-Piechaczyk Chapter 8 - Non-Lipidated LC3 is Essential for Mouse Hepatitis Virus Infection , Pages 129-136 , Julia Noack, Riccardo Bernasconi, Maurizio Molinari Chapter 9 - Suppression of Innate Antiviral Immunity after Hepatitis C Virus Infection: Role of the Unfolded Protein Response and Autophagy , Pages 137-159 , Steve S.-L. Chen, Po-Yuan Ke Chapter 10 - Mycobacterial Survival in Alveolar Macrophages as a Result of Coronin-1a Inhibition of Autophagosome Formation , Pages 161-170 , Shintaro Seto, Kunio Tsujimura, Toshinobu Horii, Yukio Koide Chapter 11 - Virulent Mycobacteria Upregulate Interleukin-6 (IL6) Production to Combat Innate Immunity , Pages 171-183 , Rajesh Kumar Dutta, Gaurav Sharma, Mohammad Aslam Khan, Mohammad Ishaq, Kapil Sharma, Sekhar Majumdar Chapter 12 - Autophagy in Parasitic Protists , Pages 185-195 , Sébastien Besteiro Chapter 13 - Cell Surface Pathogen Receptor CD46 Induces Autophagy , Pages 197-209 , Pierre-Emmanuel Joubert Chapter 14 - Helicobacter pylori Infection and Autophagy: A Paradigm for Host–Microbe Interactions , Pages 211-223 , Ted C.H. Wu, Nicola L. Jones Chapter 15 - Autophagy is Required during Monocyte–Macrophage Differentiation , Pages 227-238 , Yan Zhang, Swati Choksi, Zhenggang Liu Chapter 16 - Role of the Autophagy Gene Atg5 in T Lymphocyte Survival and Proliferation , Pages 239-244 , Ming-Xiao He, Ying Wan, You-Wen He Chapter 17 - Sepsis-Induced Autophagy is a Protective Mechanism against Cell Death , Pages 247-268 , Daniel A. Escobar, Ana M. Botero, Hernando Gomez, Brian S. Zuckerbraun Chapter 18 - Blockage of Lysosomal Degradation is Detrimental to Cancer Cell Survival: Role of Autophagy Activation , Pages 269-281 , Jessica L. Schwartz-Roberts, Robert Clarke Chapter 19 - Autophagy as a Sensitization Target in Cancer Therapy , Pages 283-291 , Xi Chen, Xiao-Ming Yin Chapter 20 - Pathogenesis of Bile Duct Lesions in Primary Biliary Cirrhosis: Role of Autophagy Followed by Cellular Senescence , Pages 293-303 , Motoko Sasaki, Yasuni Nakanuma Chapter 21 - Autophagy and NADPH Oxidase Activity Tend to Regulate Angiogenesis in Pulmonary Artery Endothelial Cells with Pulmonary Hypertension , Pages 305-314 , Ru-Jeng Teng Chapter 22 - Role of Autophagy in Heart Disease , Pages 315-328 , Ben Loos, Balindiwe Sishi, Anna-Mart Engelbrecht Chapter 23 - Regulation of Autophagy in Obesity-Induced Cardiac Dysfunction , Pages 329-340 , Xihui Xu, Jun Ren Chapter 24 - Cytochrome P4502E1, Oxidative Stress, JNK, and Autophagy in Acute Alcohol-Induced Fatty Liver , Pages 341-356 , Arthur I. Cederbaum Chapter 25 - Autophagy-Independent Tumor Suppression: Role of UV Radiation Resistance Associated Gene , Pages 357-367 , Shanshan He, Chengyu Liang Chapter 26 - Chaperone-Mediated Autophagy and Degradation of Mutant Huntingtin Protein , Pages 369-382 , Peter O. Bauer, Nobuyuki Nukina Chapter 27 - The Role of Atg8 Homologue in Lewy Body Disease , Pages 383-389 , Kunikazu Tanji, Fumiaki Mori, Koichi Wakabayashi Index , Pages 391-398

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections.

Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.

This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process.

• Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway, or both
• Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
• Covers recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagy presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases.

This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

• Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field
• Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control
• Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level
• Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease Annotation Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagypresents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field . Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control. Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level . Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections.

Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

• Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field
• Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level
• Organized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosis
• Explores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast
  

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. * Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field * Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level * Organized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosis * Explores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections.

Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.

• Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or both
• Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation
• States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or bothIntroduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. This title offers a guide to both cellular processes while inciting researchers to explore their potentially important connection. This book aids in understanding the importance and necessity of the role of autophagy in health and disease, especially in the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. It acts as a guide to both cellular processes and their potentially important connections. Provides an examination of the role of autophagy in health and disease. Suitable for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases, this four-volume work offers a guide to cellular processes.