Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging : Volume 1 - Molecular Mechanisms

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. * Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field * Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level * Organized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosis * Explores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast Content: Front-matter , Page i Copyright , Page ii Dedication , Page iii Dedication , Page v Preface , Pages xi-xii , M.A. Hayat Contributors , Pages xiii-xv , Patrizia Agostinis, Macarena Alanís Sánchez, Gizem Ayna, Mario D. Cordero, David Cotán, Ana Delgado Pavón, Mario de la Mata, Luisa De Martino, Guido R.Y. De Meyer, Karin Eberhart, Alejandro Fernández-Vega, László Fésüs, Filomena Fiorito, Yuuki Fujiwara, Padmaja Gade, Juan Garrido Maraver, David A. Gewirtz, Madan M. Godbole, Devrim Gozuacik, Rafael Guerrero-Preston, et al. List of Contributions Projected in Volumes 2–4 , Pages xvii-xix Abbreviations and Glossary , Pages xxi-xxix Chapter 1 - Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1–4 , Pages 1-32 , M.A. Hayat Chapter 2 - Mechanisms of Regulation of p62 in Autophagy and Implications for Health and Diseases , Pages 35-44 , Kenji Takagi, Tsunehiro Mizushima Chapter 3 - Molecular Mechanisms Underlying the Role of Autophagy in Neurodegenerative Diseases , Pages 45-59 , S. Tariq Ahmad, Jin-A. Lee Chapter 4 - Roles of Multiple Types of Autophagy in Neurodegenerative Diseases , Pages 61-68 , Tomohiro Kabuta, Yuuki Fujiwara, Keiji Wada Chapter 5 - Autophagy and Crohn’s Disease: Towards New Therapeutic Connections , Pages 69-77 , Kris Nys, Séverine Vermeire, Patrizia Agostinis Chapter 6 - The Role of Autophagy in Atherosclerosis , Pages 79-90 , Cédéric F. Michiels, Dorien M. Schrijvers, Guido R.Y. De Meyer, Wim Martinet Chapter 7 - Treatment of Diabetic Cardiomyopathy through Upregulating Autophagy by Stimulating AMP-Activated Protein Kinase , Pages 91-103 , Yuran Xie, Zhonglin Xie Chapter 8 - Hyperglycemia-Associated Oxidative Stress Induces Autophagy: Involvement of the ROS-ERK/JNK-p53 Pathway , Pages 105-115 , Ying Tang, Jiangang Long, Jiankang Liu Chapter 9 - Role of Autophagy in Cellular Defense Against Inflammation , Pages 117-130 , Eun-Kyeong Jo, Dong-Min Shin, Jae-Min Yuk Chapter 10 - Mitophagy Plays a Protective Role in Fibroblasts from Patients with Coenzyme Q 10 Deficiency , Pages 131-144 , David Cotán, Ángeles Rodríguez Hernández, Mario D. Cordero, Juan Garrido Maraver, Manuel Oropesa-Ávila, Mario de la Mata, Alejandro Fernández-Vega, Carmen Pérez Calero, Marina Villanueva Paz, Ana Delgado Pavón, Macarena Alanís Sánchez, José A. Sánchez Alcázar Chapter 11 - The Presence of Dioxin in Kidney Cells Induces Cell Death with Autophagy , Pages 145-155 , Filomena Fiorito, Luisa De Martino Chapter 12 - Molecular Mechanisms Underlying the Activation of Autophagy Pathways by Reactive Oxygen Species and their Relevance in Cancer Progression and Therapy , Pages 159-178 , Noemí Rubio Romero, Patrizia Agostinis Chapter 13 - Induction of Autophagic Cell Death by Anticancer Agents , Pages 179-202 , Karin Eberhart, Ozlem Oral, Devrim Gozuacik Chapter 14 - Immunogenicity of Dying Cancer Cells–The Inflammasome Connection: Autophagic Death Arrives on the Scene , Pages 203-219 , Gizem Ayna, Goran Petrovski, László Fésüs Chapter 15 - Selenite-Mediated Cellular Stress, Apoptosis, and Autophagy in Colon Cancer Cells , Pages 221-233 , Emil Rudolf Chapter 16 - Enhancement of Cell Death in High-Grade Glioma Cells: Role of N-(4-Hydroxyphenyl) Retinamide-Induced Autophagy , Pages 235-250 , Meenakshi Tiwari, Lokendra K. Sharma, Madan M. Godbole Chapter 17 - Cisplatin Exposure of Squamous Cell Carcinoma Cells Leads to Modulation of the Autophagic Pathway , Pages 251-267 , Rafael Guerrero-Preston, Edward A. Ratovitski Chapter 18 - Autophagy, Stem Cells, and Tumor Dormancy , Pages 271-276 , David A. Gewirtz Chapter 19 - Death-Associated Protein Kinase 1 Suppresses Tumor Growth and Metastasis via Autophagy and Apoptosis , Pages 277-292 , Padmaja Gade, Dhan V. Kalvakolanu Chapter 20 - TRIM13, Novel Tumor Suppressor: Regulator of Autophagy and Cell Death , Pages 293-304 , Dhanendra Tomar, Rajesh Singh Chapter 21 - Hypoxia-Induced Autophagy Promotes Tumor Cell Survival , Pages 305-317 , Qipeng Zhang, Ke Zen Index , Pages 319-329

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections.

Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.

This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process.

• Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway, or both
• Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
• Covers recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections. Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process. Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway, or bothIntroduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammationCovers recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagy presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases.

This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

• Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field
• Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control
• Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level
• Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease Annotation Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagypresents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field . Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control. Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level . Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections.

Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

• Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field
• Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level
• Organized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosis
• Explores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast
  

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections.

Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.

• Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or both
• Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation
• States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. Presents the most advanced information regarding the role of the autophagic system in life and death and whether autophagy acts fundamentally as a cell survivor or cell death pathway or bothIntroduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. This title offers a guide to both cellular processes while inciting researchers to explore their potentially important connection. This book aids in understanding the importance and necessity of the role of autophagy in health and disease, especially in the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. It acts as a guide to both cellular processes and their potentially important connections. Provides an examination of the role of autophagy in health and disease. Suitable for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases, this four-volume work offers a guide to cellular processes.