Autoimmune Neurology (Volume 133) (Handbook of Clinical Neurology, Volume 133)

__Autoimmune Neurology__ presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. * Includes comprehensive coverage of autoimmune neurology * Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders * Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities Content: Series Page Page ii Copyright Page iv Handbook of Clinical Neurology 3rd Series Pages v-vi Foreword Page vii Michael J. Aminoff, François Boller, Dick F. Swaab Preface Page ix Sean J. Pittock, Angela Vincent Contributors Pages xi-xiii Chapter 1 - Introduction to autoimmune neurology Pages 3-14 Sean J. Pittock, Angela Vincent Chapter 2 - Signaling molecules of the CNS as targets of autoimmunity Pages 17-38 Eduardo E. Benarroch Chapter 3 - The blood–brain barrier Pages 39-59 Birgit Obermeier, Ajay Verma, Richard M. Ransohoff Chapter 4 - Overview of the immune system Pages 61-76 Kay L. Medina Chapter 5 - Cellular, synaptic, and circuit effects of antibodies in autoimmune CNS synaptopathies Pages 77-93 Ankit Jain, Rita Balice-Gordon Chapter 6 - Immunopathology: autoimmune glial diseases and differentiation from multiple sclerosis Pages 95-106 Bogdan F. GH. Popescu, Claudia F. Lucchinetti Chapter 7 - Neuropathology of autoimmune encephalitides Pages 107-120 Jan Bauer, Christian G. Bien Chapter 8 - Neurologic autoimmunity: mechanisms revealed by animal models Pages 121-143 Monika Bradl, Hans Lassmann Chapter 9 - Detection methods for neural autoantibodies Pages 147-163 Patrick Waters, Philippa Pettingill, Bethan Lang Chapter 10 - Paraneoplastic and idiopathic autoimmune neurologic disorders: approach to diagnosis and treatment Pages 165-183 Sean J. Pittock, Jacqueline Palace Chapter 11 - Voltage-gated potassium channel–complex autoimmunity and associated clinical syndromes Pages 185-197 Sarosh R. Irani, Angela Vincent Chapter 12 - Anti-NMDAR encephalitis and other glutamate and GABA receptor antibody encephalopathies Pages 199-217 Marienke A.A.M. De Bruijn, Maarten J. Titulaer Chapter 13 - Autoimmune epilepsy Pages 219-245 Jeffrey Britton Chapter 14 - Autoimmune dementia and encephalopathy Pages 247-267 Eoin P. Flanagan, Daniel A. Drubach, Bradley F. Boeve Chapter 15 - Autoimmunity in neuropsychiatric disorders Pages 269-282 Ester Coutinho, Angela Vincent Chapter 16 - Central nervous system vasculitis in adults and children Pages 283-300 Marinka Twilt, Susanne M. Benseler Chapter 17 - Autoimmune movement disorders Pages 301-315 Andrew Mckeon, Angela Vincent Chapter 18 - Autoimmune sleep disorders Pages 317-326 Michael H. Silber Chapter 19 - Autoimmune myelopathies Pages 327-351 Eoin P. Flanagan Chapter 20 - Autoimmunity in visual loss Pages 353-376 Axel Petzold, Sui Wong, Gordon T. Plant Chapter 21 - Autoimmune AQP4 channelopathies and neuromyelitis optica spectrum disorders Pages 377-403 Shannon R. Hinson, Vanda A. Lennon, Sean J. Pittock Chapter 22 - Autoimmune autonomic disorders Pages 405-416 Andrew Mckeon, Eduardo E. Benarroch Chapter 23 - Autoimmune-mediated peripheral neuropathies and autoimmune pain Pages 417-446 Christopher J. Klein Chapter 24 - Neuromuscular junction disorders Pages 447-466 Jan Verschuuren, Ellen Strijbos, Angela Vincent Chapter 25 - Autoimmune muscle disease Pages 467-484 Andrew Mammen Chapter 26 - Autoimmune neurologic disorders in children Pages 485-510 Ming Lim, Mark Gorman Chapter 27 - Current and future immunotherapy targets in autoimmune neurology Pages 511-536 Melody Y. Hu, Panos Stathopoulos, Kevin C. O’connor, Sean J. Pittock, Richard J. Nowak Errata Page 537 Index Pages 539-551

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system.

Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease.

This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders.

• Includes comprehensive coverage of autoimmune neurology
• Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders
• Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

"Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders"--Publisher's description Autoimmune neurologic disease results when the immune response to the body's own organs run wild and causes the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. This title deals with this topic.