Aulton's Pharmaceutics E-Book : The Design and Manufacture of Medicines

Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient. Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art. • provides a logical, comprehensive account of drug design and manufacture • includes the science of formulation and drug delivery • designed and written for newcomers to the design of dosage forms New to this edition • New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. • Twenty-two new contributors. • Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. • Thoroughly revised and updated throughout. What is ‘pharmaceutics’? 0 1. Design of dosage forms 0 Peter York PART 1: Scientific principles of dosage form design 2. Dissolution and solubility 00 Michael E. Aulton 3. Properties of solutions 00 Michael E. Aulton 4. Surfaces and interfaces 00 Graham Buckton 5. Disperse systems 00 David Attwood 6. Rheology Christopher Marriot 7. Kinetics 00 W. John Pugh PART 2: Particle science and powder technology 00 8. Solid-state properties 00 Graham Buckton 9. Particle size analysis 00 J.N. Staniforth, Kevin M.G. Taylor 10. Particle size reduction and size separation 00 Michael E. Aulton, J.N. Staniforth 11. Mixing 00 Andrew M. Twitchell 12. Powder flow 00 Michael E. Aulton PART 3: Pharmaceutical microbiology and sterilization 00 13. Fundamentals of microbiology 00 Geoffrey W. Hanlon 14. Pharmaceutical applications of microbiological techniques 00 Norman A. Hodges 15. Action of physical and chemical agents on microorganisms 00 Geoffrey W. Hanlon, Norman A. Hodges 16. Principles of sterilization 00 Susannah E. Walsh, Jean-Yves Maillard 17. Sterilization in practice 00 Jean-Yves. Maillard, Susannah E. Walsh PART 4: Biopharmaceutical principles of drug delivery 000 18. Introduction to biopharmaceutics 000 Marianne Ashford 19. Gastrointestinal tract - physiology and drug absorption 000 Marianne Ashford 20. Bioavailability - physicochemical and dosage form factors 000 Marianne Ashford 21. Assessment of biopharmaceutical properties 000 Marianne Ashford 22. Dosage regimens 000 John H. Collett, Soraya Dhillon PART 5: Dosage form design and manufacture 000 23. Pharmaceutical preformulation 000 Simon Gaisford 24. Solutions 000 Sudaxshina Murdan 25. Clarification 000 Andrew M. Twitchell 26. Suspensions 000 Susan A. Barker 27. Emulsions and Creams 000 Gillian M.Eccleston 28. Powders, granules and granulation 000 Michael E. Aulton, Malcolm P. Summers` 29. Drying 000 Michael E. Aulton 30. Tablets and compaction 000 Göran Alderborn 31. Modified-release oral drug delivery 000 Abdul W. Basit, Emma L. McConnell 32. Coating of tablets and multiparticulates 000 Stuart C. Porter 33. Hard capsules 000 Brian E. Jones 34. Soft capsules 000 Keith G. Hutchison, Josephine Ferdinando 35 Dissolution testing of solid dosage forms Abdul W. Basit, Ana Cristina Freire 36 Parenteral drug delivery Robert Lowe 37. Pulmonary drug delivery 000 Kevin M. G. Taylor 38. Nasal drug delivery 000 Gary P. Martin, Alison B. Lansley 39. Topical and transdermal drug delivery 000 Adrian C. Williams 40. Wound dressings 000 Gillian M. Eccleston 41. Ocular drug delivery 000 Hala Fadda, Ashkan Khalili, Peng T. Khaw, Steve Brocchini 42. Rectal and vaginal drug delivery 000 Joseph J. Tukker, Sanjay Garg 43. Design and administration of medicines for children and the elderly 000 Catherine Tuleu, David Wright 44. The formulation and manufacture of plant medicines 000 G. Brian Lockwood 45. Pharmaceutical nanotechnology and nanomedicines 000 Yvonne Perrie 46. Delivery of biopharmaceuticals 000 Ijeoma F. Uchegbu, A. G. Shätzlein Part 6: PACKAGING AND STABILITY OF PHARMACEUTICAL PRODUCTS 47. Packaging 000 Sudaxshina Murdan 48. Chemical stability in dosage forms 000 Andrew R. Barnes 49. Product stability and stability testing 000 Michael E. Aulton 50. Microbial contamination, spoilage and preservation of medicines 000 Norman A. Hodges Machine generated contents note: 1.Design of dosage forms / Peter York 2.Dissolution and solubility / Michael E. Aulton 3.Properties of solutions / Michael E. Aulton 4.Surfaces and interfaces / Graham Buckton 5.Disperse systems / David Attwood 6.Rheology / Christopher Marriott 7.Kinetics / W. John Pugh 8.Solid-state properties / Graham Buckton 9.Particle size analysis / John N. Staniforth / Kevin M.G. Taylor 10.Particle size reduction and size separation / Michael E. Aulton / John N. Staniforth 11.Mixing / Andrew M. Twitchell 12.Powder flow / Michael E. Aulton 13.Fundamentals of microbiology / Geoffrey W. Hanlon 14.Pharmaceutical applications of microbiological techniques / Norman A. Hodges 15.Action of physical and chemical agents on microorganisms / Geoffrey W. Hanlon / Norman A. Hodges 16.Principles of sterilization / Susannah E. Walsh / Jean-Yves Maillard 17.Sterilization in practice / Jean-Yves Maillard / Susannah E. Walsh Note continued: 18.Introduction to biopharmaceutics / Marianne Ashford 19.Gastrointestinal tract physiology and drug absorption / Marianne Ashford 20.Bioavailability physicochemical and dosage form factors / Marianne Ashford 21.Assessment of biopharmaceutical properties / Marianne Ashford 22.Dosage regimens / John H. Collett / Soraya Dhillon 23.Pharmaceutical preformulation / Simon Gaisford 24.Solutions / Sudaxshina Murdan 25.Clarification / Andrew M. Twitchell 26.Suspensions / Susan A. Barker 27.Emulsions and creams / Gillian M. Eccleston 28.Powders, granules and granulation / Michael E. Aulton / Malcolm P. Summers 29.Drying / Michael E. Aulton 30.Tablets and compaction / Göran Alderborn 31.Modified-release oral drug delivery / Emma L. McConnell / Abdul W. Basit 32.Coating of tablets and multiparticulates / Stuart C. Porter 33.Hard capsules / Brian E. Jones 34.Soft capsules / Keith G. Hutchison / Josephine Ferdinando Note continued: 35.Dissolution testing of solid dosage forms / Ana Cristina Freire / Abdul W. Basit 36.Parenteral drug delivery / Robert Lowe 37.Pulmonary drug delivery / Kevin M.G. Taylor 38.Nasal drug delivery / Gary P. Martin / Alison B. Lansley 39.Topical and transdermal drug delivery / Adrian C. Williams 40.Wound dressings / Gillian M. Eccleston 41.Ocular drug delivery / Hala Fadda / Ashkan Khalili / Peng Tee Khaw / Steve Brocchini 42.Rectal and vaginal drug delivery / Sanjay Garg / Josef J. Tukker 43.Design and administration of medicines for children and the elderly / Catherine Tuleu / David Wright 44.The formulation and manufacture of plant medicines / G. Brian Lockwood 45.Pharmaceutical nanotechnology and nanomedicines / Yvonne Perrie 46.Delivery of biopharmaceuticals / Ijeoma F. Uchegbu / Andreas G. Schäzlein 47.Packaging / Sudaxshina Murdan Note continued: 48.Chemical stability in dosage forms / Andrew R. Barnes 49.Product stability and stability testing / Michael E. Aulton 50.Microbial contamination, spoilage and preservation of medicines / Norman A. Hodges.

Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient.

Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art.

New to this edition

• New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London.
• Twenty-two new contributors.
• Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals.
• Thoroughly revised and updated throughout.

• provides a logical, comprehensive account of drug design and manufacture
• includes the science of formulation and drug delivery
• designed and written for newcomers to the design of dosage forms

New to this edition

• New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London.
• Twenty-two new contributors.
• Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals.
• Thoroughly revised and updated throughout.

"Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.