Atypical Parkinsonian Disorders: Clinical and Research Aspects (Current Clinical Neurology)

Despite an enormous amount of research in the past five years, our understanding of atypical parkinsonian disorders (APD) remains very much in its infancy. In Atypical Parkinsonian Disorders: Clinical and Research Aspects, a panel of highly knowledgeable and thoughtful investigators comprehensively reviews, for the first time, what is known not only about the cause and treatment of these devastating disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors focus on progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy, dementia with Lewy bodies, and familial atypical parkinsonism, covering the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions. Comprehensive and authoritative, Atypical Parkinsonian Disorders: Clinical and Research Aspects will enable clinicians to better diagnose, treat, and provide ongoing support for their parkinsonian patients, as well as provide researchers from all fields with encouragement and focus to pursue new research directions. A Comprehensive Review Of What Is Known Not Only About The Cause And Treatment Of Atypical Parksonian Disorders, But Also The Issues That Clinicians, Researchers, Patients, And Caregivers Face In Dealing With Them. The Authors Cover The Basic Science (history, Epidemiology, Genetics, Pathology, Nosology, Computer Modeling, And Animal Models), Detailed Clinical And Laboratory Assessments, And Available Diagnostic Tools, Including Neuropsychiatric, Neurologic, Neuropsychologic, Speech, Electrophysiologic, And Imaging Evaluations. Current And Future Therapeutic Approaches Are Also Detailed, Along With Extensive Discussions About Future Research Directions. An Accompanying Dvd Contains Video Segments That Demonstrate How To Examine Patients With These Disorders, How To Differentiate Them, And How To Systematically Use Specific Tests To Better Characterize Them. What Is An Atypical Parkinsonian Disorder? / Irene Litvan -- Historical Issues And Atypical Parkinsonian Disorders / Christopher G. Goetz -- Epidemiology Of Progressive Supranuclear Palsy And Multiple System Atrophy / Adam Zermansky And Yoav Ben-shlomo -- Neuropathology Of Atypical Parkinsonian Disorders / Ian R.a. Mackenzie -- Animal Models Of Tauopathies / Jada Lewis And Michael Hutton -- Neurodegenerative[alpha]-synucleinopathies / Michel Goedert And Maria Grazia Spillantini -- Computer Modeling In Basal Ganglia Disorders / José Luis Contreras-vidal. Atypical Parkinsonian Disorders: Neuropathology And Nosology / Charles Duyckaerts -- Genetics Of Atypical Parkinsonism: Implications For Nosology / Thomas Gasser -- Medical History And Physical Examination In Parkinsonian Syndromes: How To Examine A Parkinsonian Syndrome / Marie Vidailhet, Frédéric Bourdain, And Jean-marc Trocello -- Role Of Neuropsychiatric Assessment In Diagnosis And Research / Dag Aarsland, Uwe Ehrt, And Clive Ballard -- Added Value Of The Neuropsychological Evaluation For Diagnosis And Research Of Atypical Parkinsonian Disorders / Bruno Dubois And Bernard Pillon. Role Of Praxis In Diagnosis And Assessment / Ramón Leiguarda -- Role Of Visuospatial Cognition Assessment In The Diagnosis And Research Of Atypical Parkinsonian Disorders / Paolo Nichelli And Anna Magherini -- Role Of Ocular Motor Assessment In Diagnosis And Research / R. John Leigh And David S. Zee -- Characterizing And Assessing Speech And Language Disturbances / Carol Frattali And Joseph R. Duffy -- Quality Of Life Assessment In Atypical Parkinsonian Disorders / Anette Schrag And Caroline E. Selai -- Progressive Supranuclear Palsy / Irene Litvan -- Corticobasal Degeneration: The Syndrome And The Disease / Bradley F. Boeve. Multiple System Atrophy / Feliz Geser And Gregor K. Wenning -- Clinical Diagnosis Of Dementia With Lewy Bodies / David J. Burn, Urs P. Mosimann, And Ian G. Mckeith -- Clinical Diagnosis Of Familial Atypical Parkinsonian Disorders / Yoshio Tsuboi, Virgilio H. Evidente, And Zbigniew K. Wszolek -- Clinical Diagnosis Of Vascular Parkinsonism And Nondegenerative Atypical Parkinsonian Disorders / Madhavi Thomas And Joseph Jankovic -- Role Of Electrophysiology In Diagnosis And Research In Atypical Parkinsonian Disorders / Josep Valls-solé -- Role Of Ct And Mri In Diagnosis And Research / Mario Savoiardo And Marina Grisol. Role Of Functional Magnetic Neuroimaging In Diagnosis And Research / Hartwig Roman Siebner And Günther Deuschl -- Pet And Spect Imaging In Atypical Parkinsonian Disorders / Alexander Gerhard And David J. Brooks -- Current And Future Therapeutic Approaches / Elmyra V. Encarnacion And Thomas N. Chase -- Rehabilitation Of Patients With Atypical Parkinsonian Disorders / Daniel K. White ... [et Al.] -- Overview And Future Research / Andrew Lees. Edited By Irene Litvan ; Foreword By Yves Agid. Includes Bibliographical References And Index. System Requirements For Accompanying Dvd: Pc/mac Compatible. Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The second edition has been extended by chapters on autoimmune pigmentary disorders (vitiligo), hairloss (alopecia areata) and cutaneous symptoms of rheumatic disorders.