Atlas of thyroid and neuroendocrine tumors markers

This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues. This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments. Front Matter ....Pages i-xii Front Matter ....Pages 1-1 Pathology and Immunohistochemistry in Thyroid Tumors (Esther Diana Rossi, Guido Fadda)....Pages 3-12 Pathology of Neuroendocrine Neoplasms: Morphological, Immunophenotypical, and Circulating Molecular Markers (Stefano La Rosa, Massimo Bongiovanni, Silvia Uccella)....Pages 13-38 Circulating Biomarkers: Biological Basis, Methods, and Interpretation Criteria (Stefan Holdenrieder)....Pages 39-48 Front Matter ....Pages 49-49 Differentiated Thyroid Cancer: Diagnosis, Therapy, and Follow-Up (Frederik A. Verburg)....Pages 51-64 Thyroglobulin and Thyroglobulin Antibodies (Luca Giovanella, Federica D’Aurizio, Renato Tozzoli, Camilla Schalin-Jantti, Ulla Feldt-Rasmussen)....Pages 65-91 Circulating Molecular Biomarkers in Thyroid Cancer (Cosimo Durante, Francesca Rosignolo, Marialuisa Sponziello, Antonella Verrienti, Sebastiano Filetti)....Pages 93-105 Circulating Epithelial Tumor Cells in Thyroid Carcinoma (Thomas Winkens, Katharina Pachmann, Martin Freesmeyer)....Pages 107-115 Front Matter ....Pages 117-117 Medullary Thyroid Carcinoma (MTC): Diagnosis, Treatment and Follow-Up (M. Alevizaki, K. Saltiki, G. Simeakis, T. Pappa)....Pages 119-132 Calcitonin and Carcinoembryonic Antigen for the Diagnosis and Management of Medullary Thyroid Carcinoma (Giuseppe Costante, Yassine Lalami, Christiane Jungels, Ahmad Awada)....Pages 133-150 Procalcitonin: Are We Ready for Clinical Use? (Pierpaolo Trimboli, Alicia Algeciras-Schimnich, Luca Giovanella)....Pages 151-157 Front Matter ....Pages 159-159 Aggressive Variants of Thyroid Carcinoma (Massimo Salvatori, Claudio Altini, Luca Zagaria, Alfonso Verrillo, Germano Perotti)....Pages 161-173 Circulating Mucins and Cytokeratins in Aggressive Thyroid Cancers (Luca Giovanella, Federica D’Aurizio, Renato Tozzoli)....Pages 175-189 Front Matter ....Pages 191-191 Measurement of Thyroid Tumor Markers on Fine-Needle Washouts (Pierpaolo Trimboli, Luca Giovanella)....Pages 193-200 Front Matter ....Pages 201-201 Neuroendocrine Tumours: Diagnosis, Therapy and Follow-up (Diego Ferone, Elena Nazzari, Federica Grillo, Stefania Sciallero, Silvia Morbelli, Franco De Cian et al.)....Pages 203-222 Circulating Markers in Neuroendocrine Tumors (Ettore Seregni, Alice Lorenzoni)....Pages 223-234 Neuroendocrine Gene Transcripts: The Role of Molecular Biomarkers in Diagnosis and Management (Lisa Bodei, Mark Kidd, Kyung Min Chung, Irvin Modlin)....Pages 235-249 This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. 鮠 this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues. This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments